Bert A. Bonsing
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View article: Patient preferences for pancreatic cancer treatment (PERSEUS): a multicenter discrete choice experiment
Patient preferences for pancreatic cancer treatment (PERSEUS): a multicenter discrete choice experiment Open
Background Pancreatic cancer has an aggressive nature, and treatment severely impacts patients’ quality of life. There is limited understanding how patients weigh treatment benefits against side effects, which hampers the development of pa…
View article: Timing of adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma: A nationwide analysis
Timing of adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma: A nationwide analysis Open
TTC in patients with upfront PDAC resection was not associated with survival, but TTC 6-12 weeks was associated with adjuvant chemotherapy completion. These findings support prioritizing postoperative recovery rather than pushing early adj…
View article: Nationwide outcomes of 1000 robotic pancreatoduodenectomies across the four phases of the learning curve
Nationwide outcomes of 1000 robotic pancreatoduodenectomies across the four phases of the learning curve Open
Background Robotic pancreatoduodenectomy (RPD) is increasingly being implemented to enhance patient recovery, but it is unclear what happens to patient outcomes after the initial learning curve. The aim of this study was to evaluate the fi…
View article: Increased incidence, survival, and registration quality of primary hepato‐pancreato‐biliary cancers in the Netherlands Cancer Registry
Increased incidence, survival, and registration quality of primary hepato‐pancreato‐biliary cancers in the Netherlands Cancer Registry Open
Given the poor survival and relatively poor performance of hepato‐pancreato‐biliary (HPB) cancers on data quality indicators for cancer registries, we assessed trends in incidence, survival, and data quality of HPB cancers within the Nethe…
View article: Surgical Complications in Patients with (borderline) Resectable Pancreatic Cancer after Neoadjuvant Therapy in the PREOPANC-2 Randomized Controlled Trial
Surgical Complications in Patients with (borderline) Resectable Pancreatic Cancer after Neoadjuvant Therapy in the PREOPANC-2 Randomized Controlled Trial Open
Objective: To compare the incidence of major surgical complications between patients with (borderline) resectable pancreatic cancer treated with neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy. Summary of Back…
View article: Oncological outcome after robot-assisted <i>versus</i> open pancreatoduodenectomy for upfront resectable cancer in the pancreatic head: a nationwide cohort analysis
Oncological outcome after robot-assisted <i>versus</i> open pancreatoduodenectomy for upfront resectable cancer in the pancreatic head: a nationwide cohort analysis Open
Background Robot-assisted pancreatoduodenectomy (RPD) aims to enhance postoperative recovery compared to open pancreatoduodenectomy (OPD). Although recent randomized trials confirmed the short-term safety of RPD, they did not confirm super…
View article: Resectability stages of pancreatic cancer: nationwide reference
Resectability stages of pancreatic cancer: nationwide reference Open
Contains fulltext : 320988.pdf (Publisher’s version ) (Open Access)
View article: Routine Imaging After Resection of Pancreatic Ductal Adenocarcinoma
Routine Imaging After Resection of Pancreatic Ductal Adenocarcinoma Open
Objective: To evaluate the utilization of routine imaging and the impact on survival after resection of pancreatic ductal adenocarcinoma (PDAC). Background: Evidence on the benefit of routine imaging after resection of PDAC on early detect…
View article: Impact of feeding strategy after pancreatoduodenectomy on delayed gastric emptying and hospital stay: nationwide study
Impact of feeding strategy after pancreatoduodenectomy on delayed gastric emptying and hospital stay: nationwide study Open
Background Delayed gastric emptying is a major contributor to prolonged hospital stay following pancreatoduodenectomy. Although enhanced recovery after surgery guidelines recommend unrestricted feeding after pancreatoduodenectomy, nationwi…
View article: Standard versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes after Whipple resection (SPARROW): a study protocol for a multicentre, open-label, randomised controlled trial
Standard versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes after Whipple resection (SPARROW): a study protocol for a multicentre, open-label, randomised controlled trial Open
ClinicalTrials.gov NCT0578431. Registered on March 23, 2023.
View article: Video-assessment of Surgical Performance in Robotic Gastro-enterostomy During Pancreatoduodenectomy
Video-assessment of Surgical Performance in Robotic Gastro-enterostomy During Pancreatoduodenectomy Open
Objective: The aim of this study is to identify learning curves for robotic gastro-enterostomy (RGE) during RPD and the predictive value of the objective structured assessment of technical skills (OSATS) score for DGE according to the Birk…
View article: Ideal Outcome after Left Pancreatectomy in North America, Germany, the Netherlands, and Sweden
Ideal Outcome after Left Pancreatectomy in North America, Germany, the Netherlands, and Sweden Open
Background: Composite outcome measures aim to provide a more holistic view when determining the effectiveness and safety of surgical interventions. Recently, ‘Ideal Outcome’ (IO) harmonized the European and American composite outcome of pa…
View article: Video Grading of Bile Duct Anastomoses During Robotic Pancreatoduodenectomy Predicts Bile Leak and Identifies the Learning Curve
Video Grading of Bile Duct Anastomoses During Robotic Pancreatoduodenectomy Predicts Bile Leak and Identifies the Learning Curve Open
Objective: To determine if video grading using Objective Structured Assessment of Technical Skills (OSATS) could estimate the risk of postoperative bile leak (BL) after robotic pancreatoduodenectomy (RPD) and to identify a learning curve e…
View article: Tumor gene expression is associated with venous thromboembolism in patients with ductal pancreatic adenocarcinoma
Tumor gene expression is associated with venous thromboembolism in patients with ductal pancreatic adenocarcinoma Open
Patients with pancreatic cancer and VTE show a different tumor gene expression profile than those without VTE. Multiple coagulation-related genes were differentially expressed in classical versus basal-like molecular subtype, suggesting th…
View article: Effects of Pancreatic Fistula After Minimally Invasive and Open Pancreatoduodenectomy
Effects of Pancreatic Fistula After Minimally Invasive and Open Pancreatoduodenectomy Open
Importance Postoperative pancreatic fistulas (POPF) are the biggest contributor to surgical morbidity and mortality after pancreatoduodenectomy. The impact of POPF could be influenced by the surgical approach. Objective To assess the clini…
View article: Intravenous Lidocaine for Refractory Pain in Patients With Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis: A Multicenter Prospective Nonrandomized Pilot Study
Intravenous Lidocaine for Refractory Pain in Patients With Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis: A Multicenter Prospective Nonrandomized Pilot Study Open
INTRODUCTION: Refractory pain is a major clinical problem in patients with pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). New, effective therapies to reduce pain are urgently needed. Intravenous lidocaine is used in…
View article: Learning curve stratified outcomes after robotic pancreatoduodenectomy: International multicenter experience
Learning curve stratified outcomes after robotic pancreatoduodenectomy: International multicenter experience Open
This international multicenter study demonstrates that most outcomes of robotic pancreatoduodenectomy continued to improve during 3 learning curve phases without a negative effect on 90-day mortality. Randomized studies are needed in high-…
View article: Interobserver Variability in the International Study Group for Pancreatic Surgery (ISGPS)-Defined Complications After Pancreatoduodenectomy
Interobserver Variability in the International Study Group for Pancreatic Surgery (ISGPS)-Defined Complications After Pancreatoduodenectomy Open
Objective: To determine the interobserver variability for complications of pancreatoduodenectomy as defined by the International Study Group for Pancreatic Surgery (ISGPS) and others. Background: Good interobserver variability for the defi…
View article: Prediction of Isolated Local Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Study
Prediction of Isolated Local Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Study Open
Background Distinguishing postoperative fibrosis from isolated local recurrence (ILR) after resection of pancreatic ductal adenocarcinoma (PDAC) is challenging. A prognostic model that helps to identify patients at risk of ILR can assist c…
View article: Assessing quality of hepato-pancreato-biliary surgery: nationwide benchmarking
Assessing quality of hepato-pancreato-biliary surgery: nationwide benchmarking Open
Background Clinical auditing is a powerful tool to evaluate and improve healthcare. Deviations from the expected quality of care are identified by benchmarking the results of individual hospitals using national averages. This study aimed t…
View article: The Added Value of Blood Glucose Monitoring in High-Risk Individuals Undergoing Pancreatic Cancer Surveillance
The Added Value of Blood Glucose Monitoring in High-Risk Individuals Undergoing Pancreatic Cancer Surveillance Open
Objectives The study aimed to investigate the added value of blood glucose monitoring in high-risk individuals (HRIs) participating in pancreatic cancer surveillance. Materials and Methods High-risk individuals with a CDKN2A/p16 germline p…
View article: Metformin boosts antitumor immunity and improves prognosis in upfront resected pancreatic cancer: an observational study
Metformin boosts antitumor immunity and improves prognosis in upfront resected pancreatic cancer: an observational study Open
Background Beyond demographic and immune factors, metabolic considerations, particularly metformin’s recognized impact in oncology, warrant exploration in treating pancreatic cancer. This study aimed to investigate the influence of metform…
View article: The Difficulty of Detecting Occult Metastases in Patients with Potentially Resectable Pancreatic Cancer: Development and External Validation of a Preoperative Prediction Model
The Difficulty of Detecting Occult Metastases in Patients with Potentially Resectable Pancreatic Cancer: Development and External Validation of a Preoperative Prediction Model Open
Occult metastases are detected in 10–15% of patients during exploratory laparotomy for pancreatic cancer. This study developed and externally validated a model to predict occult metastases in patients with potentially resectable pancreatic…