Dermot McGovern
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View article: Current and Future Role of Precision Medicine in the Management of IBD
Current and Future Role of Precision Medicine in the Management of IBD Open
Purpose of Review Inflammatory bowel disease (IBD) poses a looming global health burden characterized by increasing prevalence and healthcare costs. This is despite significant advances in available therapeutics and disease monitoring stra…
View article: Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood
Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood Open
Our findings suggest that maternal IBD-associated antibodies cross the placenta barrier and may be associated with intestinal inflammation and imbalanced microbiota colonization. Whether these serological profiles negatively influence the …
View article: Differences in Anti-αvβ6 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease
Differences in Anti-αvβ6 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease Open
Background Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), have complex pathologies requiring precise diagnostic tools. We evaluated the clinical utility of anti-integrin αvβ6 antibodies in d…
View article: Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort
Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort Open
Despite advances in clinical proteomics, translating protein biomarker discoveries into clinical use remains challenging due to the technical complexity of the validation process. Targeted MS‐based proteomic approaches such as parallel rea…
View article: Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort
Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort Open
Despite advances in clinical proteomics, translating protein biomarker discoveries into clinical use remains challenging due to the technical complexity of the validation process. Targeted MS‐based proteomic approaches such as parallel rea…
View article: Micronutrients are associated with endoscopic postoperative recurrence in Crohn’s disease: a multicenter prospective cohort study in North america
Micronutrients are associated with endoscopic postoperative recurrence in Crohn’s disease: a multicenter prospective cohort study in North america Open
Background and Aims Diet may influence the disease course in inflammatory bowel disease, but its role in postoperative outcomes for Crohn’s disease (CD) remains unclear. This study aimed to assess the association of macro- and micronutrien…
View article: Maternal IBD-related antibodies are associated with early life gut inflammatory status and microbiota composition: insights from cord blood
Maternal IBD-related antibodies are associated with early life gut inflammatory status and microbiota composition: insights from cord blood Open
Purpose Antibodies in peripheral blood are used to aid in the diagnosis of inflammatory bowel disease (IBD), but their presence in neonatal cord blood and potential effects on early life development remain unknown. Methods We measured anti…
View article: The <i>PTPN2</i> rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis
The <i>PTPN2</i> rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis Open
Inflammatory bowel disease (IBD) patients often exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 (PTPN2), causes gut microbiota …
View article: Relationship of Intestinal Ultrasound With Clinical, Biochemical, and Endoscopic Disease Severity in Acute Severe Ulcerative Colitis: A Blinded, Prospective Study
Relationship of Intestinal Ultrasound With Clinical, Biochemical, and Endoscopic Disease Severity in Acute Severe Ulcerative Colitis: A Blinded, Prospective Study Open
INTRODUCTION: The utility of intestinal ultrasound (IUS) for acute severe ulcerative colitis (ASUC) is understudied. We correlated IUS to clinical, biochemical, and endoscopic disease severity in ASUC. METHODS: In a blinded, prospective st…
View article: Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort
Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort Open
Despite advances in clinical proteomics, translating protein biomarker discoveries into clinical use remains challenging due to the technical complexity of the validation process. Targeted MS-based proteomics approaches such as parallel re…
View article: TL1A overexpression in Crohn’s Disease and mice alters Paneth cells and microbiota promoting ileal inflammation
TL1A overexpression in Crohn’s Disease and mice alters Paneth cells and microbiota promoting ileal inflammation Open
Paneth cells regulate host-microbial homeostasis and defects in autophagy and host defense pathways have been associated with inflammatory bowel diseases (IBD). Genetic variants in TL1A ( TNFSF15 ) and its receptor DR3 ( TNFRSF25 ) have be…
View article: THE RELATIONSHIP BETWEEN POLYGENIC RISK SCORE AND THE GUT MICROBIOME IN PEDIATRIC CROHN’S DISEASE PATIENTS
THE RELATIONSHIP BETWEEN POLYGENIC RISK SCORE AND THE GUT MICROBIOME IN PEDIATRIC CROHN’S DISEASE PATIENTS Open
INTRODUCTION Emerging data show that many individuals are discordant between their inflammatory bowel disease (IBD) genetic risk and disease presence, implying that environmental influences, such as gut microbiome, may play a key role in d…
View article: Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB)
Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB) Open
Background The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn’s disease (CD) in patients with perianal fistula(s) (PAF). Methods A panel of international experts in the fie…
View article: Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction Open
LRRK2 polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson’s disease and Crohn’s disease (CD) lead to LRRK2 kinase hyperactivity and suppress autophagy. This connection suggests that LRRK2 kinase inhibition, a therapeuti…
View article: The JAK inhibitor, Tofacitinib, Corrects the Overexpression of CEACAM6 and Limits Susceptibility to AIEC Caused by Reduced Activity of the IBD Associated Gene,<i>PTPN2</i>
The JAK inhibitor, Tofacitinib, Corrects the Overexpression of CEACAM6 and Limits Susceptibility to AIEC Caused by Reduced Activity of the IBD Associated Gene,<i>PTPN2</i> Open
Background and Aims A cohort of patients with inflammatory bowel disease (IBD) exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 …
View article: Artificial Intelligence- and Physician-Interpreted Stool Image Characteristics Correlate With C-Reactive Protein Among Inpatients With Acute Severe Ulcerative Colitis: A Pilot Study
Artificial Intelligence- and Physician-Interpreted Stool Image Characteristics Correlate With C-Reactive Protein Among Inpatients With Acute Severe Ulcerative Colitis: A Pilot Study Open
Background Stool characteristics are used as a measure of ulcerative colitis (UC) disease activity, but they have not been validated against objective inflammation. We aimed to determine whether stool characteristics measured by trained ar…
View article: Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis
Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis Open
Background and Aims Biomarkers that integrate genetic and environmental factors and predict outcome in complex immune diseases such as inflammatory bowel disease (IBD; including Crohn’s disease [CD] and ulcerative colitis [UC]) are needed.…
View article: Landscape of <i>TPMT</i> and <i>NUDT15</i> Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients
Landscape of <i>TPMT</i> and <i>NUDT15</i> Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients Open
Background Patients with inflammatory bowel disease (IBD) exhibit considerable interindividual variability in medication response, highlighting the need for precision medicine approaches to optimize and tailor treatment. Pharmacogenetics (…
View article: Asians Have More Perianal Crohn Disease and Ocular Manifestations Compared with White Americans
Asians Have More Perianal Crohn Disease and Ocular Manifestations Compared with White Americans Open
Background: Inflammatory bowel disease (IBD) is increasing in Asians. We sought to better understand differences in IBD between Asians and whites in the United States (US). Methods: We used data from the Sinai-Helmsley Alliance for Researc…
View article: Radiomics-Based Analysis of Intestinal Ultrasound Images for Inflammatory Bowel Disease: A Feasibility Study
Radiomics-Based Analysis of Intestinal Ultrasound Images for Inflammatory Bowel Disease: A Feasibility Study Open
Background The increasing adoption of intestinal ultrasound (IUS) for monitoring inflammatory bowel diseases (IBD) by IBD providers has uncovered new challenges regarding standardized image interpretation and limitations as a research tool…
View article: Paradigm shift in biomarker translation: a pipeline to generate clinical grade biomarker candidates from DIA-MS discovery
Paradigm shift in biomarker translation: a pipeline to generate clinical grade biomarker candidates from DIA-MS discovery Open
Clinical biomarker development has been stymied by inaccurate protein quantification from mass spectrometry (MS) discovery data and a prolonged validation process. To mitigate these issues, we created the Targeted Extraction Assessment of …
View article: Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease
Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease Open
BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence (POR) of Crohn’s disease (CD). However, its prognostic value is uncertain, in part, due to difficulties studying it non-invasively. AIM To ev…
View article: Mapping and characterization of structural variation in 17,795 human genomes
Mapping and characterization of structural variation in 17,795 human genomes Open
A key goal of whole-genome sequencing for studies of human genetics is to interrogate all forms of variation, including single-nucleotide variants, small insertion or deletion (indel) variants and structural variants. However, tools and re…
View article: Corrigendum: Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α
Corrigendum: Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α Open
[This corrects the article DOI: 10.3389/fimmu.2024.1342477.].
View article: UNAFFECTED RELATIVES WITH HIGH IBD POLYGENIC RISK SCORES FROM MULTIPLEX CROHN’S DISEASE FAMILIES CARRY MICROBIOMES THAT PROTECT IL-10 DEFICIENT MICE AGAINST INTESTINAL INFLAMMATION
UNAFFECTED RELATIVES WITH HIGH IBD POLYGENIC RISK SCORES FROM MULTIPLEX CROHN’S DISEASE FAMILIES CARRY MICROBIOMES THAT PROTECT IL-10 DEFICIENT MICE AGAINST INTESTINAL INFLAMMATION Open
Genetic and environmental influences contribute to Crohn’s disease (CD) development. However, the relationship between these two factors is unclear, limiting insights into CD pathophysiology, as well as interventions to prevent disease. To…
View article: Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α
Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α Open
Introduction We evaluated baseline Clearance of anti-tumor necrosis factors and human leukocyte antigen variant (HLA DQA1*05) in combination as poor prognostic factors (PPF) of pharmacokinetic (PK) origin impacting immune response (formati…
View article: NAD <sup>+</sup> precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction
NAD <sup>+</sup> precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction Open
Environmental enteric dysfunction (EED) is a diffuse small bowel disorder associated with poor growth, inadequate responses to oral vaccines, and nutrient malabsorption in millions of children worldwide. We identify loss of the small intes…
View article: DOP04 Screening and management of fistula cancers in patients with perianal fistulising Crohn’s Disease: an expert consensus
DOP04 Screening and management of fistula cancers in patients with perianal fistulising Crohn’s Disease: an expert consensus Open
Background Fistula cancer is a rare and often devastating diagnosis in patients with perianal fistulising Crohn’s disease (CD). Fistula cancer management is a complex process requiring multi-disciplinary effort. However, given the low inci…
View article: ECCO Global Grant Genetic risk factors for IBD in its emergent phase in sub-Saharan Africa
ECCO Global Grant Genetic risk factors for IBD in its emergent phase in sub-Saharan Africa Open
Background and Aims Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is an idiopathic, chronic, and frequently disabling inflammatory disorder of the intestines characterized by a dysregulated m…