Brian Buck
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View article: Moving towards precision post-stroke rehabilitation: A systematic review and meta-analysis of wearable sensor-derived walking activities in daily living
Moving towards precision post-stroke rehabilitation: A systematic review and meta-analysis of wearable sensor-derived walking activities in daily living Open
Background Physical rehabilitation interventions can enhance functional capacity after stroke, but improved ability doesn’t always lead to better real-world performance. Understanding this gap is key to optimizing post-stroke recovery stra…
View article: Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes
Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes Open
Background Infarct volume is an imaging biomarker of ischemic tissue injury strongly correlated with poststroke outcomes and reperfusion benefit. We aimed to evaluate the follow‐up infarct volume (FIV) difference corresponding to a 1%, 5%,…
View article: Early Motor Cortex Connectivity and Neuronal Reactivity in Intracerebral Hemorrhage: A Continuous-Wave Functional Near-Infrared Spectroscopy Study
Early Motor Cortex Connectivity and Neuronal Reactivity in Intracerebral Hemorrhage: A Continuous-Wave Functional Near-Infrared Spectroscopy Study Open
Insights into motor cortex remodeling may enable the development of more effective rehabilitation strategies during the acute phase. We aim to assess the affected and unaffected motor/premotor/somatosensory cortex resting state functional …
View article: Multiple Health Care Encounters Prior to Diagnosis of Cerebral Venous Thrombosis
Multiple Health Care Encounters Prior to Diagnosis of Cerebral Venous Thrombosis Open
Women were more likely to have multiple health care encounters prior to cerebral venous thrombosis diagnosis. However, this was not associated with worse outcomes.
View article: Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke
Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke Open
Importance The cumulative burden of chronic vascular and neurodegenerative changes contributes to brain frailty, which may reduce the brain’s capacity to recover from acute ischemic stroke (AIS). The association between brain frailty marke…
View article: Predictors and Outcomes of ASPECTS Decay during Interfacility Transfers in Patients with Large Vessel Occlusion
Predictors and Outcomes of ASPECTS Decay during Interfacility Transfers in Patients with Large Vessel Occlusion Open
Background: Some patients with large vessel occlusion (LVO) are first evaluated at primary stroke centers (PSCs) before transfer to a comprehensive stroke center (CSC) for endovascular thrombectomy (EVT). A subgroup of these patients exper…
View article: Early Motor Cortex Dysconnectivity and Compensatory Neuronal Reactivity in Intracerebral Hemorrhage: A Continuous-Wave Functional Near-Infrared Spectroscopy Study
Early Motor Cortex Dysconnectivity and Compensatory Neuronal Reactivity in Intracerebral Hemorrhage: A Continuous-Wave Functional Near-Infrared Spectroscopy Study Open
Insights into motor cortex remodelling may allow for the implementation of better rehabilitation strategies in the acute phase. We aim to assess the affected and unaffected motor/premotor/somatosensory cortex resting state functional conne…
View article: The Acute Stroke System of Treatment Across Canada: Findings from a National Stroke Centre Survey
The Acute Stroke System of Treatment Across Canada: Findings from a National Stroke Centre Survey Open
Background: Stroke is a devastating disease, but the disability due to stroke can be avoided or reduced through timely access to treatment and care. This study surveyed all designated stroke centres across Canada to better understand the n…
View article: Tenecteplase versus Alteplase and First-Pass Reperfusion in Endovascular Thrombectomy
Tenecteplase versus Alteplase and First-Pass Reperfusion in Endovascular Thrombectomy Open
IV thrombolytic agent did not influence the probability of first-pass reperfusion.
View article: Safety and Real-World Effectiveness in the Transition from Alteplase to Tenecteplase for Stroke Treatment
Safety and Real-World Effectiveness in the Transition from Alteplase to Tenecteplase for Stroke Treatment Open
Background: Tenecteplase has been shown to be non-inferior to alteplase for the treatment of acute ischemic stroke within 4.5 hours of stroke onset. While not formally approved by regulatory authorities, many jurisdictions have transitione…
View article: Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions
Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions Open
Purpose Monte Carlo simulations and short diffusion time measurements have suggested neurite beading and swelling as the underlying mechanism of reduced diffusion in acute stroke, although the observed diffusion time dependence is often he…
View article: Intravenous Tenecteplase Compared With Alteplase for Acute Ischemic Stroke in Canada (AcT): Bridging the Gap From Academia to Regulatory Approval
Intravenous Tenecteplase Compared With Alteplase for Acute Ischemic Stroke in Canada (AcT): Bridging the Gap From Academia to Regulatory Approval Open
Background In the AcT (Alteplase compared to Tenecteplase) trial, tenecteplase (0.25 mg/kg) was non‐inferior to alteplase (0.9 mg/kg) for efficacy, and similar in terms of safety in patients with acute ischemic stroke presenting within 4.5…
View article: B.3 Early motor cortex dysconnectivity and compensatory neuronal reactivity in acute stroke is dependent on the side of stroke
B.3 Early motor cortex dysconnectivity and compensatory neuronal reactivity in acute stroke is dependent on the side of stroke Open
Background: We aim to assess the resting state functional connectivity (RSFC) and reactivity with functional near-infrared spectroscopy (fNIRS) in patients with acute stroke compared to age, sex and comorbidity-matched subjects. Methods: P…
View article: P.047 Optimizing workflow of the initial patient visit to the stroke prevention clinic
P.047 Optimizing workflow of the initial patient visit to the stroke prevention clinic Open
Background: Referrals to the Stroke prevention clinic with incomplete preliminary investigations decrease clinic capacity due to additional workload and the need for follow-ups. We aimed to improve the efficacy of the initial visit by incr…
View article: Recurrent Stroke Prevention Strategies in Patients Receiving Acute Stroke Reperfusion Therapies (CoPrime Study Survey)
Recurrent Stroke Prevention Strategies in Patients Receiving Acute Stroke Reperfusion Therapies (CoPrime Study Survey) Open
Background: Patients who have undergone reperfusion treatments, like all ischemic stroke patients, are at risk of recurrent ischemic strokes in the first 90 days. Current guidelines recommend single antiplatelet therapy for secondary preve…
View article: Acute Blood Pressure Lowering and Risk of Ischemic Lesions on MRI After Intracerebral Hemorrhage
Acute Blood Pressure Lowering and Risk of Ischemic Lesions on MRI After Intracerebral Hemorrhage Open
Importance Diffusion-weighted imaging (DWI) lesions have been demonstrated in patients with subacute intracerebral hemorrhage (ICH), suggesting ischemic injury, which may be related to blood pressure (BP) reduction. Objective To test the h…
View article: Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial
Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial Open
Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with mi…
View article: Feasibility of telephone and computerized cognitive testing as a secondary outcome in an acute stroke clinical trial: A mixed methods sub-study of the AcT Trial
Feasibility of telephone and computerized cognitive testing as a secondary outcome in an acute stroke clinical trial: A mixed methods sub-study of the AcT Trial Open
Introduction: Post-stroke cognitive impairment is associated with impaired quality of life. Remote testing provides a potential avenue to measure cognitive outcomes efficiently. Patients and Methods: Prospective cognitive outcomes were col…
View article: Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial
Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial Open
View article: Thrombolysis in Patients With Versus Without Visible Occlusion: A Secondary Analysis From the AcT Trial
Thrombolysis in Patients With Versus Without Visible Occlusion: A Secondary Analysis From the AcT Trial Open
View article: Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial
Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial Open
Background and Purpose In the ESCAPE-NA1 (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischaemic Stroke) trial, treatment with nerinetide was associated with improved outcomes in patients who did not receive intravenous alt…
View article: Prediction of atrial fibrillation after a stroke event: A systematic review with meta-analysis
Prediction of atrial fibrillation after a stroke event: A systematic review with meta-analysis Open
Three of the 58 identified multivariable prediction models for AF after stroke demonstrated excellent statistical performance on meta-analysis. However, prospective validation is required to understand the effectiveness of these models in …
View article: Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial
Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial Open
Objective To evaluate the relationship between infarct pattern, inferred stroke mechanism and risk of recurrence in patients with ischaemic stroke. The question is clinically relevant to optimise secondary stroke prevention investigations …
View article: Brain Frailty and Functional Outcomes after Thrombolysis for Acute Ischaemic Stroke: Insights from the Act Trial
Brain Frailty and Functional Outcomes after Thrombolysis for Acute Ischaemic Stroke: Insights from the Act Trial Open
View article: Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial
Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial Open
Background About 25% of patients with acute ischemic stroke have lacunar infarct on follow‐up imaging. In this secondary analysis from the AcT (Alteplase Compared With Tenecteplase) trial, we assessed if there is variation in safety or eff…
View article: Evaluating the Monro-Kellie Doctrine: Contralateral Hemisphere Shrinkage in Intracerebral Hemorrhage Patients
Evaluating the Monro-Kellie Doctrine: Contralateral Hemisphere Shrinkage in Intracerebral Hemorrhage Patients Open
View article: Impact of Clinical Trial Enrollment on Thrombolysis Workflow in a Mobile Stroke Unit: Results from the AcT Trial
Impact of Clinical Trial Enrollment on Thrombolysis Workflow in a Mobile Stroke Unit: Results from the AcT Trial Open
Background: The Edmonton-based mobile stroke unit (MSU), which transports patients to the University of Alberta Hospital (UAH), enrolled patients in the Intravenous Tenecteplase Compared with Alteplase for Acute Ischemic Stroke (AcT) trial…
View article: Automatic Matching Algorithms to Identify Eligible Participants for Stroke Trials: A Proof-of-Concept Study
Automatic Matching Algorithms to Identify Eligible Participants for Stroke Trials: A Proof-of-Concept Study Open
Background: Clinical trials often struggle to recruit enough participants, with only 10% of eligible patients enrolling. This is concerning for conditions like stroke, where timely decision-making is crucial. Frontline clinicians typically…
View article: Prevalence of ipsilateral “vulnerable carotid plaques with <50 % stenosis” on CT angiography in embolic stroke of undetermined source
Prevalence of ipsilateral “vulnerable carotid plaques with <50 % stenosis” on CT angiography in embolic stroke of undetermined source Open
In ESUS patients undergoing thrombectomy for anterior circulation large vessel occlusion, vulnerable carotid plaques are more prevalent ipsilateral to the intracranial occlusion. Irregular plaque surface, and a higher degree of stenosis we…
View article: Consent-Related Outcomes in the Alteplase Compared to Tenecteplase Trial
Consent-Related Outcomes in the Alteplase Compared to Tenecteplase Trial Open
Deferral of consent was broadly acceptable to participants in the AcT trial as demonstrated by low rates of withdrawal and by survey results. Door-to-randomization times using deferral of consent in AcT were short, although a system of pro…