Bulat A. Ziganshin
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View article: Thoracic Aortic Aneurysm and Giant Cell Arteritis: Clarifying the Link
Thoracic Aortic Aneurysm and Giant Cell Arteritis: Clarifying the Link Open
We aim to better define the association between thoracic aortic aneurysm (TAA) and giant cell arteritis (GCA), thereby enhancing cross-diagnosis, monitoring, and therapy. Literature review: We used a two-step search approach to the availab…
View article: Genetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms
Genetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms Open
Objective: Thoracic aortic aneurysms (TAAs) and intracranial aneurysms (ICAs) share overlapping genetic and pathophysiological mechanisms, yet the genetic interplay between these conditions remains insufficiently explored. This study aimed…
View article: Genetics of aortic aneurysm disease: 10 key points for the practitioner
Genetics of aortic aneurysm disease: 10 key points for the practitioner Open
Central Message: Genetic understanding of TAA has advanced immensely in the two decades since the landmark initial mapping of the human genome.Aortic surgeons need to be familiar with the genetic landscape of TAA.Perspective Statement: Cur…
View article: Somatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F
Somatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F Open
The JAK2 V617F somatic variant is a well-known driver of myeloproliferative neoplasms (MPN) associated with an increased risk for athero-thrombotic cardiovascular disease. Recent studies have demonstrated its role in the development of tho…
View article: Gene Commonality in Arterial Circuits Throughout the Body
Gene Commonality in Arterial Circuits Throughout the Body Open
The common genetic underpinnings of thoracic aortic aneurysms and aneurysms and dissections of several other major arterial circuits have been described in the literature. These include thoracic and abdominal aortic aneurysms, thoracic and…
View article: Midterm follow-up of composite graft replacement of the aortic root (30-year experience)—remarkably safe, effective, and durable
Midterm follow-up of composite graft replacement of the aortic root (30-year experience)—remarkably safe, effective, and durable Open
This ultra-long-term experience finds ARR to be extraordinarily safe, effective, and durable, with minimal long-term bleeding, thromboembolism, or graft failure. This experience provides a standard of durability for ARR against which ultra…
View article: Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease
Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease Open
Ascending thoracic aortic aneurysms may be fatal upon rupture or dissection and remain a leading cause of death in the developed world. Understanding the pathophysiology of the development of ascending thoracic aortic aneurysms may help re…
View article: Exome Sequencing of 1429 Patients with Thoracic Aortic Disease at the Yale Aortic Institute: what Have We Learned?
Exome Sequencing of 1429 Patients with Thoracic Aortic Disease at the Yale Aortic Institute: what Have We Learned? Open
Objective: One in five cases of thoracic aortic aneurysm and dissection (TAAD) are familial. Although more than 60 genes (with varying degrees of evidence) have been implicated in causing TAAD, suspicious variants are found in only one-thi…
View article: Bicuspid Aortopathy is NOT More Virulent: Data from the Yale Aortic Institute
Bicuspid Aortopathy is NOT More Virulent: Data from the Yale Aortic Institute Open
Objectives: Guidelines for surgical correction of patients with ascending thoracic aortic aneurysm (ATAA) with a bicuspid aortic valve (BAV) have oscillated over the years. In this study, we outline the natural history of the ascending aor…
View article: “Big Data” Analyses Underlie Clinical Discoveries at the AorticInstitute
“Big Data” Analyses Underlie Clinical Discoveries at the AorticInstitute Open
This issue of the Yale Journal of Biology and Medicine (YJBM) focuses on Big Data and precision analytics in medical research. At the Aortic Institute at Yale New Haven Hospital, the vast majority of our investigations have emanated from o…
View article: Safety of cerebrospinal fluid drainage in descending and thoracoabdominal aortic replacement surgery
Safety of cerebrospinal fluid drainage in descending and thoracoabdominal aortic replacement surgery Open
CSFD is associated with minor complications, without major sequalae. It is a safe practice and likely contributes innocuously to decreased SCI in patients undergoing open repair of DTAA and TAAA.
View article: Long-term follow-up of Cabrol fistula for uncontrollable bleeding: A life-saving procedure
Long-term follow-up of Cabrol fistula for uncontrollable bleeding: A life-saving procedure Open
The Cabrol fistula is an important tool for the thoracic aortic surgeon to have in the toolbox. We found the Cabrol fistula to be extremely effective at controlling bleeding, with no late persistent fistula flow and no late false aneurysm …
View article: Comparison of Genes Associated with Thoracic and Abdominal Aortic Aneurysms
Comparison of Genes Associated with Thoracic and Abdominal Aortic Aneurysms Open
Aneurysms impacting the ascending thoracic aorta and the abdominal aorta affect patient populations with distinct clinical characteristics. Through a literature review, this paper compares the genetic associations of ascending thoracic aor…
View article: The natural history of aortic root aneurysms
The natural history of aortic root aneurysms Open
The aortic root has a different embryologic origin from all other segments of the human aorta, a feature that likely confers unique susceptibilities, anatomical patterns, and clinical behavior of aneurysm disease in this vital location. In…
View article: Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta
Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta Open
For decades, aortic surgery has relied on size criteria for intervention on the ascending aorta. While diameter has served well, diameter alone falls short of an ideal criterion. Herein, we examine the potential application of other, nondi…
View article: Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University Open
Aims This study aims to outline the ‘true’ natural history of ascending thoracic aortic aneurysm (ATAA) based on a cohort of patients not undergoing surgical intervention. Methods and results The outcomes, risk factors, and growth rates of…
View article: Full calcium jacket: Conservative management of a traumatic aortic injury
Full calcium jacket: Conservative management of a traumatic aortic injury Open
We describe the case of an elderly male patient who presented with a proximal descending aortic aneurysm after a motorcycle accident in 1977. We concluded that the aorta had been transected at that time. In a rather unconventional manner, …
View article: KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection
KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection Open
Background: KIF6 (kinesin family member 6), a protein coded by the KIF6 gene, serves an important intracellular function to transport organelles along microtubules. In a pilot study, we found that a common KIF6 Trp719Arg variant increased …
View article: Aortic Valve Replacement in the Failing Left Ventricle: Worthwhile?
Aortic Valve Replacement in the Failing Left Ventricle: Worthwhile? Open
Purpose: According to the 2020 American College of Cardiology/American Heart Association guidelines, the aortic valve should be replaced in the setting of severe aortic stenosis or regurgitation, independent of left ventricular function (e…
View article: 70th International Congress of the European Society for Cardiovascular and Endovascular Surgery and 7th International Meeting on Aortic Diseases
70th International Congress of the European Society for Cardiovascular and Endovascular Surgery and 7th International Meeting on Aortic Diseases Open
AORTA is proud to publish the abstracts from the 2022 joint IMAD (International Meeting on Aortic Diseases) and ESCVS (European Society for Cardiovascular Surgery) meeting in Liege, Belgium.