Brian C. Callaghan
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View article: 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2026
12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2026 Open
The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and to…
View article: The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes
The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes Open
Background Obesity increases the risk of diabetic peripheral neuropathy (DPN). However, past studies have typically assessed obesity using anthropometric measurements. Our primary aim determined associations between detailed obesity measur…
View article: Atypical diabetic neuropathies
Atypical diabetic neuropathies Open
Diabetes is one of the most common conditions in the world and is associated with a broad range of adverse effects in multiple organ systems. Roughly half of all patients with diabetes will develop a typical distal, symmetric polyneuropath…
View article: Neurologic Medication Costs in a Direct-to-Consumer Pharmacy vs Commercial Insurance Plans
Neurologic Medication Costs in a Direct-to-Consumer Pharmacy vs Commercial Insurance Plans Open
Importance Given increasing costs of neurologic medications, there is a need to explore alternative options to minimize medication spending. Objective To compare 2024 neurologic medication costs from commercial insurance plans with those a…
View article: Nonglycemic and Glycemic Risk Factors for Painful Neuropathic Symptoms and for Distal Symmetrical Polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study
Nonglycemic and Glycemic Risk Factors for Painful Neuropathic Symptoms and for Distal Symmetrical Polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study Open
OBJECTIVE The clinical presentation, symptoms, and signs of neuropathy vary substantially. We determined whether painful neuropathic symptoms and distal symmetrical polyneuropathy (DSPN) were associated with different risk factors in a lon…
View article: Nonglycemic and glycemic risk factors for painful neuropathic symptoms and for distal symmetrical polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study
Nonglycemic and glycemic risk factors for painful neuropathic symptoms and for distal symmetrical polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study Open
Objective: The clinical presentation, symptoms, and signs of neuropathy vary substantially. We determined whether painful neuropathic symptoms and distal symmetrical polyneuropathy (DSPN) were associated with different risk factors in a lo…
View article: Nonglycemic and glycemic risk factors for painful neuropathic symptoms and for distal symmetrical polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study
Nonglycemic and glycemic risk factors for painful neuropathic symptoms and for distal symmetrical polyneuropathy (DSPN) in the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study Open
Objective: The clinical presentation, symptoms, and signs of neuropathy vary substantially. We determined whether painful neuropathic symptoms and distal symmetrical polyneuropathy (DSPN) were associated with different risk factors in a lo…
View article: Estimating the Risk of Lower Extremity Complications in Adults Newly Diagnosed With Diabetic Polyneuropathy: Retrospective Cohort Study
Estimating the Risk of Lower Extremity Complications in Adults Newly Diagnosed With Diabetic Polyneuropathy: Retrospective Cohort Study Open
Background Diabetes-related lower extremity complications, such as foot ulceration and amputation, are on the rise, currently affecting nearly 131 million people worldwide. Methods for early detection of individuals at high risk remain elu…
View article: The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type
The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type Open
Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods…
View article: Heterozygous and Homozygous <i>RFC1 AAGGG</i> Repeat Expansions are Common in Idiopathic Peripheral Neuropathy
Heterozygous and Homozygous <i>RFC1 AAGGG</i> Repeat Expansions are Common in Idiopathic Peripheral Neuropathy Open
Objective Biallelic intronic AAGGG repeat expansions in RFC1 cause Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome and may also contribute to isolated sensory neuropathy. The clinical significance of both heterozygous a…
View article: Severe insulin‐deficient diabetes is at the opposite end of the neuropathy spectrum to mild aged‐related diabetes
Severe insulin‐deficient diabetes is at the opposite end of the neuropathy spectrum to mild aged‐related diabetes Open
The effect of diabetes subtypes on neuropathy prevalence and metabolic drivers of this relationship are unknown. Using electronic medical records from 50 diabetes care centers in eight states of India with biothesiometer and complete pheno…
View article: Cost Trends of New-To-Market Neurologic Medications
Cost Trends of New-To-Market Neurologic Medications Open
NTM medications for neurologic conditions have substantial and increasing individual and societal costs, which was not observed for older generic medications. These data suggest a need for policies to limit the financial burden of NTM medi…
View article: Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer
Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer Open
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating adverse effect of neurotoxic chemotherapy characterized by symptoms such as numbness, tingling, and weakness. Effective monitoring and detection of C…
View article: 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2025
12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2025 Open
The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and to…
View article: Comparison of intraepidermal nerve fiber density and confocal corneal microscopy for neuropathy
Comparison of intraepidermal nerve fiber density and confocal corneal microscopy for neuropathy Open
Objective Compare the diagnostic characteristics of intraepidermal nerve fiber density (IENFD) and confocal corneal microscopy (CCM) for distal symmetric polyneuropathy (DSP) and small fiber neuropathy (SFN). Methods Participants with obes…
View article: Intravenous immunoglobulin and plasma exchange prescribing patterns for Guillain‐Barre Syndrome in the United States—2001 to 2018
Intravenous immunoglobulin and plasma exchange prescribing patterns for Guillain‐Barre Syndrome in the United States—2001 to 2018 Open
Introduction/Aims Randomized controlled trials show that repeat intravenous immunoglobulin (IVIG) dosing and plasma exchange (PLEX) followed by IVIG (combination therapy) have no additional therapeutic benefit in Guillain‐Barre Syndrome (G…
View article: Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer (Preprint)
Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer (Preprint) Open
BACKGROUND Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating adverse effect of neurotoxic chemotherapy characterized by symptoms such as numbness, tingling, and weakness. Effective monitoring and detection of …
View article: Possible sex and racial disparities in myasthenia gravis care
Possible sex and racial disparities in myasthenia gravis care Open
Introduction/Aims Given the importance of early diagnosis and treatment of myasthenia gravis (MG), it is critical to understand disparities in MG care. We aimed to determine if there are any differences in testing, treatment, and/or access…
View article: Message From the Editors to Our Reviewers
Message From the Editors to Our Reviewers Open
The high quality and standards of Neurology ® owe a great deal to the contributions of our dedicated peer reviewers.The expert insight, deeper technical knowledge, and passion that reviewers bring to our process not only improve each manus…
View article: Burden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization
Burden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization Open
Compared with a matched cohort of adults with a hospitalization or emergency department visit for influenza infection, those with COVID-19 had significantly fewer health care encounters for 6 major neurologic diagnoses over a year of follo…
View article: Safety and Efficacy of Topiramate in Individuals With Cryptogenic Sensory Peripheral Neuropathy With Metabolic Syndrome
Safety and Efficacy of Topiramate in Individuals With Cryptogenic Sensory Peripheral Neuropathy With Metabolic Syndrome Open
Importance Cryptogenic sensory peripheral neuropathy (CSPN) is highly prevalent and often disabling due to neuropathic pain. Metabolic syndrome and its components increase neuropathy risk. Diet and exercise have shown promise but are limit…
View article: Diabetic Neuropathies
Diabetic Neuropathies Open
Identifying and appropriately diagnosing the neuropathies of diabetes is key to preventing progression. Until better disease-modifying therapies are identified, management remains focused on diabetes and metabolic risk factor control and p…
View article: Patient Travel Distance to Neurologist Visits
Patient Travel Distance to Neurologist Visits Open
We found that nearly 1 in 5 Medicare beneficiaries who saw a neurologist traveled ≥50 miles 1-way for care, and travel burden was most common for lower-prevalence neurologic conditions that required coordinated multidisciplinary care. Impo…