Brian J. Cole
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View article: Generative AI in consumer health: leveraging large language models for health literacy and clinical safety with a digital health framework
Generative AI in consumer health: leveraging large language models for health literacy and clinical safety with a digital health framework Open
Generative AI, powered by large language models, is transforming consumer health by enhancing health literacy and delivering personalized health education. However, ensuring clinical safety and effectiveness requires a robust digital healt…
View article: Does Self-Reported Drug Allergy Influence Clinically Significant Outcome Improvement and Graft Failure Rates After Meniscal Allograft Transplantation of the Knee?
Does Self-Reported Drug Allergy Influence Clinically Significant Outcome Improvement and Graft Failure Rates After Meniscal Allograft Transplantation of the Knee? Open
Background: Emerging research suggests that immune responses may influence results after various orthopaedic operations. This study aimed to determine if similar relationships exist in meniscal allograft transplantation (MAT). Purpose: To …
View article: Defining Clinically Meaningful Subgroups in Patients Undergoing Arthroscopic Rotator Cuff Repair Using Unsupervised Machine Learning
Defining Clinically Meaningful Subgroups in Patients Undergoing Arthroscopic Rotator Cuff Repair Using Unsupervised Machine Learning Open
Background: Outcomes after arthroscopic rotator cuff repair (RCR) are frequently measured through clinically significant outcomes (CSOs) such as the minimal clinically important difference, the substantial clinical benefit, and the Patient…
View article: Cell-Free Aragonite-Based Scaffold With Bone Marrow Aspirate Concentrate Augmentation for Osteochondral Defects of the Knee
Cell-Free Aragonite-Based Scaffold With Bone Marrow Aspirate Concentrate Augmentation for Osteochondral Defects of the Knee Open
Background: Damage to the joint surface, which affects articular cartilage and the underlying subchondral bone, is a common cause for significant knee pain and disfunction. The use of CartiHeal Agili-C, a cell-free aragonite-based implant,…
View article: The effect of comorbid anxiety and major depression on functional outcomes in meniscectomy
The effect of comorbid anxiety and major depression on functional outcomes in meniscectomy Open
Introduction: Psychiatric disorders such as depression and anxiety are prevalent but often unrecognized in orthopedic settings. While psychiatric conditions are known to affect functional outcomes in a variety of orthopedic procedures, lim…
View article: Posterior Capsular Imbrication for Dynamic Genu Valgum
Posterior Capsular Imbrication for Dynamic Genu Valgum Open
Symptomatic genu recurvatum, defined as knee hyperextension beyond 5° with symptoms of pain or instability, is uncommon and presents a challenging treatment paradigm for orthopaedic surgeons. Treatment options focus on initial nonoperative…
View article: Biointegrative Nail Raftering Improves Pain and Function in Patients With Subchondral Insufficiency of the Knee
Biointegrative Nail Raftering Improves Pain and Function in Patients With Subchondral Insufficiency of the Knee Open
Level IV, therapeutic case series.
View article: Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis
Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis Open
Background: Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue. Objectives: To compare MAT survivorship and conversion to arthroplasty in patients <40 and ≥40 years old. Data sources…
View article: Surface Termination Engineering of 2D Titanium Carbides for Light-Activated Soft Robotics Applications
Surface Termination Engineering of 2D Titanium Carbides for Light-Activated Soft Robotics Applications Open
The transition metal carbide (TMC) Ti3C2Tx exhibits exceptional electrical conductivity, photothermal conversion, and mechanical flexibility. The latter two properties are useful for creating coatings that convert light into heat, which ca…
View article: Lateral meniscal allograft transplantation with concomitant osteochondral allograft of the lateral femoral condyle and trochlea: a mid-term outcome case report
Lateral meniscal allograft transplantation with concomitant osteochondral allograft of the lateral femoral condyle and trochlea: a mid-term outcome case report Open
Introduction: Meniscal deficiency and osteochondral defects of the knee are difficult pathologies to treat in isolation for knee preservationists. In conjunction, surgical treatment options may appear limited or daunting; however recent li…
View article: Surgical Predictors of Clinical Outcome 6 Years After Revision ACL Reconstruction
Surgical Predictors of Clinical Outcome 6 Years After Revision ACL Reconstruction Open
Background: Revision anterior cruciate ligament (ACL) reconstruction has been documented to have inferior outcomes compared with primary ACL reconstruction. The reasons why remain unknown. Purpose: To determine whether surgical factors per…
View article: A Novel Machine Learning Model to Predict Revision ACL Reconstruction Failure in the MARS Cohort
A Novel Machine Learning Model to Predict Revision ACL Reconstruction Failure in the MARS Cohort Open
Background: As machine learning becomes increasingly utilized in orthopaedic clinical research, the application of machine learning methodology to cohort data from the Multicenter ACL Revision Study (MARS) presents a valuable opportunity t…
View article: Articular cartilage debridement results in short-term significant improvements in patient-reported outcomes for large areas of cartilage loss of the femur in the setting of mild to moderate knee osteoarthritis
Articular cartilage debridement results in short-term significant improvements in patient-reported outcomes for large areas of cartilage loss of the femur in the setting of mild to moderate knee osteoarthritis Open
Introduction: Chondroplasty is a surgical option for chondral defects, but its effect on larger cartilage defects in the setting of knee osteoarthritis remains unclear. Objectives: This study aims to evaluate patient-reported outcomes (PRO…
View article: Chondrocyte Response to Fresh Autologous Conditioned Serum Versus Freeze-Dried Allogenic Conditioned Serum
Chondrocyte Response to Fresh Autologous Conditioned Serum Versus Freeze-Dried Allogenic Conditioned Serum Open
Objective To investigate the cytokine release profile and histological response of human cartilage after exposure to autologous conditioned serum (ACS) and freeze-dried allogenic conditioned serum (FD-CS). Design Cartilage explants were co…
View article: Radiographs demonstrate poor accuracy for evaluation of postoperative osseous integration of osteochondral allografts in the knee
Radiographs demonstrate poor accuracy for evaluation of postoperative osseous integration of osteochondral allografts in the knee Open
Introduction: This study evaluates the inter-rater reliability and accuracy of radiographs in assessing healing of osteochondral allografts (OCA) in the knee compared with computed tomography (CT) imaging is currently unknown. Methods: A r…
View article: Poster 284: The Effect of Pressurized Carbon Dioxide Lavage on Osteochondral Allograft Preparation: A Comparative Study
Poster 284: The Effect of Pressurized Carbon Dioxide Lavage on Osteochondral Allograft Preparation: A Comparative Study Open
Objectives: Osteochondral allografts (OCA) transplantation is often utilized for treating osteochondral lesions of the knee due to limited cartilage regenerative capabilities. The use of concentrated bone marrow aspirate (cBMA) has gained …
View article: Poster 263: Revision and Primary Osteochondral Allograft Transplantation Provide Clinical Benefit at Midterm Follow-up: A Matched Cohort Analysis of Patient-Reported Outcomes, Reoperations, and Failures
Poster 263: Revision and Primary Osteochondral Allograft Transplantation Provide Clinical Benefit at Midterm Follow-up: A Matched Cohort Analysis of Patient-Reported Outcomes, Reoperations, and Failures Open
Objectives: Prior studies have observed promising short-term outcomes following revision osteochondral allograft (OCA) transplantation, resulting in significant improvement in pain relief, functional outcomes, and quality of life. However,…
View article: Poster 229: Intra-articular VEGF and MMP-1 Are the Primary Drivers of Worse Baseline KOOS Symptoms and Quality of Life Subscores at Time of Knee Chondroplasty
Poster 229: Intra-articular VEGF and MMP-1 Are the Primary Drivers of Worse Baseline KOOS Symptoms and Quality of Life Subscores at Time of Knee Chondroplasty Open
Objectives: Biomarkers are a topic of interest in orthopaedics in the setting of osteoarthritis and patients undergoing knee arthroscopy for any reason. However, in patients undergoing knee arthroscopy for chondral defects, the influence o…
View article: Poster 293: Tendon Center Is Offset From Native Footprint and Tunnel Center in Bone-Patellar Tendon-Bone Grafts
Poster 293: Tendon Center Is Offset From Native Footprint and Tunnel Center in Bone-Patellar Tendon-Bone Grafts Open
Objectives: Much literature has been devoted to determining the proper tunnel positioning during arthroscopic anterior cruciate ligament (ACL) reconstruction (ACLR). However, to date, no literature has assessed whether the tunnel centroid …
View article: Poster 306: Establishing the Minimum Clinically Important Difference Two Years Following Medial Patellofemoral Ligament Reconstruction
Poster 306: Establishing the Minimum Clinically Important Difference Two Years Following Medial Patellofemoral Ligament Reconstruction Open
Objectives: Medial patellofemoral ligament (MPFL) reconstruction is used to address cases of recurrent patellar instability. Minimal clinically important difference (MCID) is an important marker that relays the smallest clinical improvemen…
View article: Poster 162: Time to Achievement of Clinically Significant Outcomes Following Revision Rotator Cuff Repair
Poster 162: Time to Achievement of Clinically Significant Outcomes Following Revision Rotator Cuff Repair Open
Objectives: To define the time required to achieve outcomes (CSOs) following revision rotator cuff repair (RCR). The main outcome was to identify an evidence-based timepoint for functional recovery, including the time needed to attain mini…
View article: Poster 128: Time to Achievement of Clinically Significant Outcomes Following Open Latarjet
Poster 128: Time to Achievement of Clinically Significant Outcomes Following Open Latarjet Open
Objective: To comprehensively define the time required to achieve outcomes (CSOs) after open Latarjet. The primary outcome was to identify an evidence-based timepoint for functional recovery, including the time needed to attain minimally c…
View article: Poster 305: Redislocation After Medial Patellofemoral Ligament Reconstruction is Correlated with Preoperative Measurements and Intraoperative Instability Measurements
Poster 305: Redislocation After Medial Patellofemoral Ligament Reconstruction is Correlated with Preoperative Measurements and Intraoperative Instability Measurements Open
Objectives: Medial patellofemoral ligament reconstruction is performed to address cases of patellar instability. Historically, this is a well-tolerated procedure though complications, including redislocation and recurrent instability can o…