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View article: Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma
Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma Open
Objective Few data are published on the long-term follow-up of ipilimumab-induced hypophysitis, a cytotoxic T-lymphocyte antigen 4 antibody. We characterized hypophysitis in terms of clinical signs, endocrinological profile, and imaging at…
View article: Pre-surgical medical treatment, a major prognostic factor of remission in acromegaly
Pre-surgical medical treatment, a major prognostic factor of remission in acromegaly Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: Ketoconazole in Cushing's Disease: Is It Worth a Try?
Ketoconazole in Cushing's Disease: Is It Worth a Try? Open
Ketoconazole is an effective drug with acceptable side effects. It should be used under close liver enzyme monitoring. Hepatotoxicity is usually mild and resolves after drug withdrawal.
View article: Outcome of multimodal therapy in operated acromegalic patients, a study in 115 patients
Outcome of multimodal therapy in operated acromegalic patients, a study in 115 patients Open
Summary Introduction Given the new therapeutic options in acromegaly, it seemed important to evaluate the outcome of operated acromegalic patients today. Objective To analyse the characteristics and short‐ and long‐term surgical outcome of…
View article: 2012 European Thyroid Association Guidelines for Genetic Testing and Its Clinical Consequences in Medullary Thyroid Cancer
2012 European Thyroid Association Guidelines for Genetic Testing and Its Clinical Consequences in Medullary Thyroid Cancer Open
Twenty-five percent of medullary thyroid cancers (MTC) are familial and inherited as an autosomal dominant trait. Three different phenotypes can be distinguished: multiple endocrine neoplasia (MEN) types 2A and 2B, in which the MTC is asso…
View article: Cushing’s disease
Cushing’s disease Open
Cushing's disease, or pituitary ACTH dependent Cushing's syndrome, is a rare disease responsible for increased morbidity and mortality. Signs and symptoms of hypercortisolism are usually non specific: obesity, signs of protein wasting, inc…
View article: Medical Treatment of Cushing’s Syndrome: Glucocorticoid Receptor Antagonists and Mifepristone
Medical Treatment of Cushing’s Syndrome: Glucocorticoid Receptor Antagonists and Mifepristone Open
Mifepristone is the first and only available glucocorticoid receptor antagonist. It was initially mainly considered as a so-called ‘contragestive’ pill due to its antiprogestin activity. In this review, we summarize the results of mifepris…
View article: Limited Value of 18F-F-DOPA PET to Localize Pancreatic Insulin-Secreting Tumors in Adults with Hyperinsulinemic Hypoglycemia
Limited Value of 18F-F-DOPA PET to Localize Pancreatic Insulin-Secreting Tumors in Adults with Hyperinsulinemic Hypoglycemia Open
18F-FDOPA PET is of limited value in localizing pancreatic insulin secreting tumors in adult HH. Our results contrast with the referential study and require further analysis.
View article: Long-Term Results of Stereotactic Radiosurgery in Secretory Pituitary Adenomas
Long-Term Results of Stereotactic Radiosurgery in Secretory Pituitary Adenomas Open
Context: To date, no study reported long-term follow-up results of gamma knife stereotactic radiosurgery (SR). Objective: The aim of the study was to determine long-term efficacy and adverse effects of SR in secreting pituitary adenomas. D…
View article: A<i>PRKAR1A</i>Mutation Associated with Primary Pigmented Nodular Adrenocortical Disease in 12 Kindreds
A<i>PRKAR1A</i>Mutation Associated with Primary Pigmented Nodular Adrenocortical Disease in 12 Kindreds Open
In conclusion, a small intronic deletion of the PRKAR1A gene is a low-penetrance cause of mainly iPPNAD; it is the first PRKAR1A genetic defect to have an association with a specific phenotype.
View article: Outcome of Gamma Knife Radiosurgery in 82 Patients with Acromegaly: Correlation with Initial Hypersecretion
Outcome of Gamma Knife Radiosurgery in 82 Patients with Acromegaly: Correlation with Initial Hypersecretion Open
Gamma knife radiosurgery may represent a therapeutic approach in patients with moderate initial or residual GH hypersecretion.
View article: Early Malignant Progression of Hereditary Medullary Thyroid Cancer
Early Malignant Progression of Hereditary Medullary Thyroid Cancer Open
These data provide initial guidelines for the timing of prophylactic thyroidectomy in asymptomatic carriers of RET gene mutations.
View article: CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2
CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2 Open
This is a consensus statement from an international group, mostly of clinical endocrinologists. MEN1 and MEN2 are hereditary cancer syndromes. The commonest tumors secrete PTH or gastrin in MEN1, and calcitonin or catecholamines in MEN2. M…
View article: Early or prophylactic thyroidectomy in MEN 2/FMTC gene carriers: results in 71 thyroidectomized patients. The French Calcitonin Tumours Study Group (GETC)
Early or prophylactic thyroidectomy in MEN 2/FMTC gene carriers: results in 71 thyroidectomized patients. The French Calcitonin Tumours Study Group (GETC) Open
BACKGROUND: Once genetic testing accurately identifies MEN 2 gene carriers, affected children are given the opportunity to undergo thyroidectomy at the earliest stages of the C-cell disease. OBJECTIVE: To define reliable parameters by whic…
View article: Risk and Penetrance of Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 2A Families with Mutations at Codon 634 of the<i>RET</i>Proto-Oncogene<sup>1</sup>
Risk and Penetrance of Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 2A Families with Mutations at Codon 634 of the<i>RET</i>Proto-Oncogene<sup>1</sup> Open
Germline mutations of the RET proto-oncogene are responsible for multiple endocrine neoplasia type 2, including multiple endocrine type 2A (MEN 2A), type 2B (MEN 2B), and familial medullary thyroid carcinoma. The relationship between speci…
View article: Interest of Routine Measurement of Serum Calcitonin: Study in a Large Series of Thyroidectomized Patients
Interest of Routine Measurement of Serum Calcitonin: Study in a Large Series of Thyroidectomized Patients Open
The aim of our study was to assess the ability of routine calcitonin (CT) measurement to improve the preoperative diagnosis of medullary thyroid carcinoma (MTC) in nodular thyroid diseases. We systematically determined basal CT in 1167 pat…
View article: Glucocorticoids Regulate Peptidyl-Glycine α-Amidating Monooxygenase Gene Expression in the Rat Hypothalamic Paraventricular Nucleus
Glucocorticoids Regulate Peptidyl-Glycine α-Amidating Monooxygenase Gene Expression in the Rat Hypothalamic Paraventricular Nucleus Open
Peptidyl-glycine alpha-amidating monooxygenase (PAM) is a posttranslational processing enzyme which catalyzes the formation of biologically active alpha-amidated peptides. The two major neuropeptides involved in the regulation of ACTH secr…
View article: Insulin-induced hypoglycemia stimulates corticotropin-releasing factor and arginine vasopressin secretion into hypophysial portal blood of conscious, unrestrained rams.
Insulin-induced hypoglycemia stimulates corticotropin-releasing factor and arginine vasopressin secretion into hypophysial portal blood of conscious, unrestrained rams. Open
Insulin-induced hypoglycemia (IIH) is a strong stimulator of pituitary ACTH secretion. The mechanisms by which IIH activates the corticotrophs are still controversial. Indeed, in rats the variations of corticotropin-releasing factor (CRF) …