David Weaver
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View article: VDAC2 and Bak scarcity in liver mitochondria enables targeting hepatocarcinoma while sparing hepatocytes
VDAC2 and Bak scarcity in liver mitochondria enables targeting hepatocarcinoma while sparing hepatocytes Open
Differences between normal tissues and invading tumors that allow tumor targeting while saving normal tissue are much sought after. Here we show that scarcity of VDAC2, and the consequent lack of Bak recruitment to mitochondria, renders he…
View article: MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart
MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart Open
Activating Ca 2+ -sensitive enzymes of oxidative metabolism while preventing calcium overload that leads to mitochondrial and cellular injury requires dynamic control of mitochondrial Ca 2+ uptake. This is ensured by the mitochondrial calc…
View article: Investigation of Fluidelastic Instability in Parallel Triangular Tube Arrays Subjected to Air Flow
Investigation of Fluidelastic Instability in Parallel Triangular Tube Arrays Subjected to Air Flow Open
One of the major considerations in the design and operation of heat exchangers is the flow-induced vibration (FIV). While there are multiple FIV excitation mechanisms, fluidelastic instability (FEI) is by far the most crucial mechanism as …
View article: Experiences of online teaching using WebCT: an institutional evaluation
Experiences of online teaching using WebCT: an institutional evaluation Open
This paper presents findings from a institutional survey investigating the use of WebCT by academic staff and students in their learning and teaching at a large Australian University. The survey was designed to ascertain how WebCT was bein…
View article: Taming the wicked problem of climate change with “virtuous challenges”: An integrated management heuristic
Taming the wicked problem of climate change with “virtuous challenges”: An integrated management heuristic Open
Climate change is widely regarded as a "wicked problem" due to its complexity, interconnectedness, and the numerous stakeholders involved in finding a solution. The wickedness of climate change is further compounded by effects which are of…
View article: A conversation with Eugene Ellis and David Weaver
A conversation with Eugene Ellis and David Weaver Open
Eugene Ellis, founder and director of The Black African and Asian Therapy Network, talks with David Weaver, activist and community developer, about his time as President of the British Association for Counselling and Psychotherapy (BACP) a…
View article: Early Resident Support for a Mega-Event: Evidence from the 2032 Brisbane Summer Olympic Games
Early Resident Support for a Mega-Event: Evidence from the 2032 Brisbane Summer Olympic Games Open
With fewer willing hosts, mega-events face uncertainty. From stakeholder and core/periphery perspectives, dystopic outcomes are occurring because mega-event elites benefit far more than peripheral stakeholders, including host city resident…
View article: Enhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle Remodeling
Enhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle Remodeling Open
Background: Cardiac contractile function requires high energy from mitochondria, and Ca 2+ from the sarcoplasmic reticulum (SR). Via local Ca 2+ transfer at close mitochondria-SR contacts, cardiac excitation feedforward regulates mitochond…
View article: Supplementary Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors
Supplementary Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors Open
Supplementary Figure S1; Supplementary Tables S1-S2.
View article: Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors
Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors Open
Purpose: Two phase I dose-escalation studies were conducted to determine the maximum tolerated dose (MTD) and safety profile of the G2 checkpoint abrogator CBP501, as a single agent and in combination with cisplatin.Experimental Design: Pa…
View article: Supplementary Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors
Supplementary Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors Open
Supplementary Figure S1; Supplementary Tables S1-S2.
View article: Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors
Data from Phase I Studies of CBP501, a G<sub>2</sub> Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors Open
Purpose: Two phase I dose-escalation studies were conducted to determine the maximum tolerated dose (MTD) and safety profile of the G2 checkpoint abrogator CBP501, as a single agent and in combination with cisplatin.Experimental Design: Pa…
View article: Morbidity and Mortality After Rib Fracture in Elderly Patients (>65 Years Old) Compared to a Younger Cohort (≤65 Years of Age) at Doctor Hospital Renaissance Health
Morbidity and Mortality After Rib Fracture in Elderly Patients (>65 Years Old) Compared to a Younger Cohort (≤65 Years of Age) at Doctor Hospital Renaissance Health Open
Young patients with blunt trauma rib fractures may have similar, if not worse, clinical outcomes than geriatric patients. These findings underscore the need for individual assessment of the patient's trauma severity independent of age, the…
View article: Genomic Regions Associated with Resistance to Soybean Rust (Phakopsora pachyrhizi) under Field Conditions in Soybean Germplasm Accessions from Japan, Indonesia and Vietnam
Genomic Regions Associated with Resistance to Soybean Rust (Phakopsora pachyrhizi) under Field Conditions in Soybean Germplasm Accessions from Japan, Indonesia and Vietnam Open
Soybean rust caused by Phakopsora pachyrhizi is one of the most important foliar diseases of soybean [Glycine max (L.) Merr.]. Although seven Rpp resistance gene loci have been reported, extensive pathotype variation in and among fungal po…
View article: Are we really progressing sustainable tourism research? A bibliometric analysis
Are we really progressing sustainable tourism research? A bibliometric analysis Open
Periodic assessment of the ‘state of play’ in research outputs is an essential process for gauging academic progress and latent trends within a field of study. Bibliometric analysis of 839 sustainable tourism-related papers over a thirty-y…
View article: A New Capacitance Sensor for Measuring the Void Fraction of Two-Phase Flow Through Tube Bundles
A New Capacitance Sensor for Measuring the Void Fraction of Two-Phase Flow Through Tube Bundles Open
Evaluating the two-phase flow parameters across tube bundles is crucial to the analysis of vibration excitation mechanisms. These parameters include the temporal and local variation of void fraction and phase redistribution. Understanding …
View article: Merging of Plant Breeding and Pathology: A History of Cotton Breeding at Auburn
Merging of Plant Breeding and Pathology: A History of Cotton Breeding at Auburn Open
Understanding the focus and history of a breeding program allows fellow researchers to build upon prior knowledge and helps determine the best expertise for specific objectives. To date, the cotton-breeding program at Auburn University has…
View article: Perturbed mitochondria–ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease
Perturbed mitochondria–ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease Open
The use of fixed fibroblasts from familial and sporadic Alzheimer's disease patients has previously indicated an upregulation of mitochondria–ER contacts (MERCs) as a hallmark of Alzheimer's disease. Despite its potential significance, the…
View article: Dalian’s unique planning history and its contested heritage in urban regeneration
Dalian’s unique planning history and its contested heritage in urban regeneration Open
Dalian is a particular Chinese city, which was occupied for half a century successively by the British, Japanese, and Russian Empires before 1949, with each imposing its own urban planning and building styles onto the city’s development. S…
View article: Cultivating the Chinese market through destination loyalty: enhancing resilience in the Maldives
Cultivating the Chinese market through destination loyalty: enhancing resilience in the Maldives Open
Market diversification, one critical means by which tourism-dependent small island states can maintain sector resilience and destination life cycle stability, requires understanding of the destination loyalty of strategic new inbound marke…
View article: Constraints to domestic ocean cruise participation among higher income Chinese adults
Constraints to domestic ocean cruise participation among higher income Chinese adults Open
The study identifies barriers to participation in cruises from domestic homeports among higher income Chinese adults. Results from 775 respondents extend leisure constraints theory by revealing that “structural” constraints (lack of knowle…