Bernhard C. Danner
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View article: Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation
Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation Open
BACKGROUND: Mitochondrial calcium (Ca 2+ ) is a key regulator of cardiac energetics by stimulating the tricarboxylic acid cycle during elevated workload. Atrial fibrillation (AF) is associated with a reduction in cytosolic Ca 2+ transient …
View article: Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation
Cytosolic calcium handling signature: integration with clinical predictors enhances prediction of post-operative atrial fibrillation Open
Background and Aims Atrial fibrillation (AF) is a prevalent complication after cardiac surgery, worsening patient outcomes. Considering the established role of Ca2+-handling abnormalities in AF pathogenesis, this study aimed to evaluate if…
View article: Extent of coronary artery disease and clinical outcomes with ticagrelor monotherapy versus aspirin after coronary artery bypass grafting: insights from the TiCAB trial
Extent of coronary artery disease and clinical outcomes with ticagrelor monotherapy versus aspirin after coronary artery bypass grafting: insights from the TiCAB trial Open
OBJECTIVES Patients with extensive coronary artery disease (CAD) have a higher risk of cardiovascular events. This post hoc analysis of the Ticagrelor in CABG (TiCAB) trial examined the association of ticagrelor monotherapy versus aspirin …
View article: Cytogenetic signatures favoring metastatic organotropism in colorectal cancer
Cytogenetic signatures favoring metastatic organotropism in colorectal cancer Open
Colorectal carcinoma (CRC) exhibits metastatic organotropism, primarily targeting liver, lung, and rarely the brain. Here, we study chromosomal imbalances (CIs) in cohorts of primary CRCs and metastases. Brain metastases show the highest b…
View article: Expression and prongostic impact of galectin-7 in human lung cancer
Expression and prongostic impact of galectin-7 in human lung cancer Open
Malignant tumors of the lung are the leading cancers worldwide. Prognostic biomarkers continue to be investigated for the detection and stratification of lung cancer for clinical use. In breast cancer cells and in lymphomas, the overexpres…
View article: Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation
Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation Open
BACKGROUND: Alterations in the buffering of intracellular Ca 2+ , for which myofilament proteins play a key role, have been shown to promote cardiac arrhythmia. It is interesting that although studies report atrial myofibrillar degradation…
View article: The ROMA trial: 7 years of trial activities and the development of the ROMA trial network
The ROMA trial: 7 years of trial activities and the development of the ROMA trial network Open
Journal Article The ROMA trial: 7 years of trial activities and the development of the ROMA trial network Get access Mario Gaudino, Mario Gaudino Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA Corresponding…
View article: Outcomes after surgical revascularization in diabetic patients
Outcomes after surgical revascularization in diabetic patients Open
OBJECTIVES Patients with diabetes mellitus (DM) undergoing coronary artery bypass grafting (CABG) have been repeatedly demonstrated to have worse clinical outcomes compared to patients without DM. The objective of this study was to evaluat…
View article: Oral Drug Absorption and Drug Disposition in Critically Ill Cardiac Patients
Oral Drug Absorption and Drug Disposition in Critically Ill Cardiac Patients Open
(1) Background: In critically ill cardiac patients, parenteral and enteral food and drug administration routes may be used. However, it is not well known how drug absorption and metabolism are altered in this group of adult patients. Here,…
View article: Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III
Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III Open
BACKGROUND: LAAOS III (Left Atrial Appendage Occlusion Study III) showed that left atrial appendage (LAA) occlusion reduces the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation undergoing cardiac surgery. T…
View article: Expression and prognostic impact of DNA-PK in human lung cancer
Expression and prognostic impact of DNA-PK in human lung cancer Open
Among all cancer patient’s lung cancer is the leading cause of death. Prognostic biomarkers continue to be investigated for the detection and stratification of lung cancer for clinical use. The DNA-dependent protein kinase is involved in m…
View article: Impact of observer experience on multi-detector computed tomography aortic valve morphology assessment and valve size selection for transcatheter aortic valve replacement
Impact of observer experience on multi-detector computed tomography aortic valve morphology assessment and valve size selection for transcatheter aortic valve replacement Open
Transcatheter aortic valve replacement (TAVR) has become the standard treatment for aortic stenosis in older patients. It increasingly relies on accurate pre-procedural planning using multidetector computed tomography (MDCT). Since little …
View article: Clinical event rate in patients with and without left main disease undergoing isolated coronary artery bypass grafting: results from the European DuraGraft Registry
Clinical event rate in patients with and without left main disease undergoing isolated coronary artery bypass grafting: results from the European DuraGraft Registry Open
OBJECTIVES Left main coronary artery disease (LMCAD) is considered an independent risk factor for clinical events after coronary artery bypass grafting (CABG). We have conducted a subgroup analysis of the multicentre European DuraGraft Reg…
View article: Regulation and Therapeutic Targeting of MTHFD2 and EZH2 in KRAS-Mutated Human Pulmonary Adenocarcinoma
Regulation and Therapeutic Targeting of MTHFD2 and EZH2 in KRAS-Mutated Human Pulmonary Adenocarcinoma Open
Activating KRAS mutations occur in about 30% of pulmonary adenocarcinoma (AC) cases and the discovery of specific inhibitors of G12C-mutated KRAS has considerably improved the prognosis for a subgroup of about 14% of non-small cell lung ca…
View article: Bacterial Spectrum and Infective Foci in Patients Operated for Infective Endocarditis: Time to Rethink Strategies?
Bacterial Spectrum and Infective Foci in Patients Operated for Infective Endocarditis: Time to Rethink Strategies? Open
Objective The rising incidence of infective endocarditis (IE) accompanied by the de-escalation of antibiotic prophylaxis and the complexity of surgical treatment makes IE a daunting foe. We reviewed all patients who underwent cardiac surge…
View article: Prognostic impact of secondary prevention after coronary artery bypass grafting—insights from the TiCAB trial
Prognostic impact of secondary prevention after coronary artery bypass grafting—insights from the TiCAB trial Open
OBJECTIVES There are disparities in the adherence to guideline-recommended therapies after coronary artery bypass graft (CABG). We therefore sought to evaluate the effect of guideline-adherent medical secondary prevention on 1-year outcome…
View article: One carbon metabolism in human lung cancer
One carbon metabolism in human lung cancer Open
Expression of MTHFD2 significantly reduces the prognosis of AC patients. Furthermore, MTHFD2 expression is crucial for survival of AC cell lines and its expression correlates with resistance against Pemetrexed. As MTHFD2 is almost not expr…
View article: Role of Annexin A1 in Squamous Cell Lung Cancer Progression
Role of Annexin A1 in Squamous Cell Lung Cancer Progression Open
Lung cancer remains the primary cause of cancer-related death worldwide, and its molecular mechanisms of tumor progression need further characterization to improve the clinical management of affected patients. The role of Annexin A1 (ANXA1…
View article: Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation
Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation Open
Aims Atrial fibrillation (AF) is a commonly occurring arrhythmia after cardiac surgery (postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced atrial contractile function is a predictor of poAF and that Ca…
View article: Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer
Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer Open
Background Targeting fibroblast growth factor receptor 1 ( FGFR1 ) is a potential treatment for squamous cell lung cancer (SQCLC). So far, treatment decision in clinical studies is based on gene amplification. However, only a minority of p…
View article: Re-exploration Early after Cardiac Surgery in Adults: The Importance of Bleeding-Related Complications
Re-exploration Early after Cardiac Surgery in Adults: The Importance of Bleeding-Related Complications Open
Background: Re-explorations soon after cardiac surgery are mostly related to bleeding or unclear hemodynamic situations possibly related to heart compression resulting from pericardial hematoma. This condition has a significant impact on m…
View article: UDP-glucose 6-dehydrogenase expression as a predictor of survival in patients with pulmonary adenocarcinoma
UDP-glucose 6-dehydrogenase expression as a predictor of survival in patients with pulmonary adenocarcinoma Open
Background: UDP-glucose-6-dehydrogenase (UGDH) plays an important role in the production of hyaluronic acid, an extracellular matrix component that is responsible for the promotion of normal cellular growth and migration. Increased levels …
View article: Expression and prognostic impact of alpha thalassemia/mental retardation X-linked and death domain-associated protein in human lung cancer
Expression and prognostic impact of alpha thalassemia/mental retardation X-linked and death domain-associated protein in human lung cancer Open
Molecular characterization of lung cancer specimens after radical surgery offers additional prognostic information and may help to guide adjuvant therapeutic procedures. The transcriptional regulators alpha thalassemia/mental retardation X…
View article: Design and training effects of a physical reality simulator for minimally invasive mitral valve surgery
Design and training effects of a physical reality simulator for minimally invasive mitral valve surgery Open
OBJECTIVES Minimally invasive mitral valve surgery (MIMVS) through an endoscopic right minithoracotomy is a well-established yet complex procedure that has a challenging learning curve. We have developed a simulator for MIMVS and evaluated…
View article: Randomized trial of ticagrelor vs. aspirin in patients after coronary artery bypass grafting: the TiCAB trial
Randomized trial of ticagrelor vs. aspirin in patients after coronary artery bypass grafting: the TiCAB trial Open
Aims The antiplatelet treatment strategy providing optimal balance between thrombotic and bleeding risks in patients undergoing coronary artery bypass grafting (CABG) is unclear. We prospectively compared the efficacy of ticagrelor and asp…
View article: Corrigendum to: ‘An early European experience with transapical off-pump mitral valve repair with NeoChord implantation [Eur J Cardiothorac Surg 2018;54:460–6]
Corrigendum to: ‘An early European experience with transapical off-pump mitral valve repair with NeoChord implantation [Eur J Cardiothorac Surg 2018;54:460–6] Open
In the version of this article initially published, author Matteo Marro's first name was misspelled. The error has been corrected above and in the online version of the article..
View article: Viabahn stent graft compared with prosthetic surgical above-knee bypass in treatment of superficial femoral artery disease
Viabahn stent graft compared with prosthetic surgical above-knee bypass in treatment of superficial femoral artery disease Open
The prosthetic surgical above-knee bypass (pAKB) is a standard therapy in superficial femoral artery (SFA) occlusive disease in absence of suitable vein. Viabahn graft has been established as a promising alternative. Since limited comparat…
View article: Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis
Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis Open
Patients with head-and-neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance of discrimination, reliable diagnostic biomarkers are still lacking. Here, we h…