Brian R Davidson
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View article: Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases
Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases Open
Here, we investigate why liver metastases reduce the efficacy of immune checkpoint inhibitors (CPI). The poor prognosis of patients with liver metastases is associated with a systemic increase in neutrophils. Using experimental models, we …
Tube2FEM: a general-purpose highly automated pipeline for flow-related processes in (embedded) tubular objects Open
This paper presents an open-source pipeline for simulating flow and flow-related processes in (embedded) tubular structures. Addressing a gap in computational fluid dynamics (CFD) and simulation sciences, it facilitates the transition from…
Assessing augmented reality displays in laparoscopic liver surgery - a clinical experience Open
Purpose Augmented Reality (AR) is considered as a potential image guidance tool to increase the safety of laparoscopic liver surgery. By overlaying surface models of the liver and hepatic blood vessels derived from pre-operative 3D imaging…
View article: The safety and efficacy of ultrasound histotripsy and human pluripotent stem cell–derived hepatic spheroid implantation as a potential therapy for treatment of congenital metabolic liver disease: Assessment in an immunocompetent rodent model
The safety and efficacy of ultrasound histotripsy and human pluripotent stem cell–derived hepatic spheroid implantation as a potential therapy for treatment of congenital metabolic liver disease: Assessment in an immunocompetent rodent model Open
Liver disease secondary to an inborn or genetic error of metabolism is a rare group of conditions often associated with chronic ill health and reduced survival. Curative treatment is mainly limited to liver transplantation with major long-…
View article: Immune cells in liver regeneration: Current evidence and potential clinical targets
Immune cells in liver regeneration: Current evidence and potential clinical targets Open
The livers' ability to regenerate after injury has attracted the investigation of possible therapeutic targets for liver disease. Cells of the immune system are considered fundamental for the initiation, propagation, and termination of liv…
View article: Reasoning in machine vision: learning to think fast and slow
Reasoning in machine vision: learning to think fast and slow Open
Reasoning is a hallmark of human intelligence, enabling adaptive decision-making in complex and unfamiliar scenarios. In contrast, machine intelligence remains bound to training data, lacking the ability to dynamically refine solutions at …
View article: Deep hashing for global registration of preoperative CT and video images for laparoscopic liver surgery
Deep hashing for global registration of preoperative CT and video images for laparoscopic liver surgery Open
Purpose Registration of computed tomography (CT) to laparoscopic video images is vital to enable augmented reality (AR), a technology that holds the promise of minimising the risk of complications during laparoscopic liver surgery. Althoug…
Real time evaluation of the liver microcirculation by whole organ machine perfusion within an MRI system Open
Objectives Machine perfusion of organs outside of the body is a growing area of research with significant applications in the fields of organ preservation and transplantation, but more widely it offers a new approach to study disease proce…
View article: Venous Resection During Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma—A Multicentre Propensity Score Matching Analysis of the Recurrence After Whipple’s (RAW) Study
Venous Resection During Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma—A Multicentre Propensity Score Matching Analysis of the Recurrence After Whipple’s (RAW) Study Open
Background: Pancreatoduodenectomy with venous resection (PDVR) may be performed to achieve tumour clearance in patients with a pancreatic ductal adenocarcinoma (PDAC) with venous involvement. This study aimed to evaluate the impact of PDVR…
View article: Guided ultrasound acquisition for nonrigid image registration using reinforcement learning
Guided ultrasound acquisition for nonrigid image registration using reinforcement learning Open
We propose a guided registration method for spatially aligning a fixed preoperative image and untracked ultrasound image slices. We exploit the unique interactive and spatially heterogeneous nature of this application to develop a registra…
View article: Inflammatory Monocytes Are Rapidly Recruited to the Post-Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes
Inflammatory Monocytes Are Rapidly Recruited to the Post-Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes Open
Liver ischaemia–reperfusion (IR) injury remains a major cause of morbidity and mortality following liver transplantation and resection. CD4+ T cells have been shown to play a key role in murine models; however, there is currently a lack of…
View article: Inflammatory Monocytes Are Rapidly Recruited to the Post Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes
Inflammatory Monocytes Are Rapidly Recruited to the Post Ischaemic Liver in Patients Undergoing Liver Transplantation and Cytokines Associated with Their Activation Correlate with Graft Outcomes Open
Liver ischaemia-reperfusion (IR) injury remains a major cause of morbidity and mortality following liver transplantation and resection. CD4+ T cells have been shown to play a key role in murine models however there is currently a lack of d…
View article: Hyperthermic intraoperative peritoneal chemotherapy and cytoreductive surgery for people with peritoneal metastases: a systematic review and cost-effectiveness analysis
Hyperthermic intraoperative peritoneal chemotherapy and cytoreductive surgery for people with peritoneal metastases: a systematic review and cost-effectiveness analysis Open
Background We compared the relative benefits, harms and cost-effectiveness of hyperthermic intraoperative peritoneal chemotherapy + cytoreductive surgery ± systemic chemotherapy versus cytoreductive surgery ± systemic chemotherapy or syste…
View article: Minimally invasive versus open pancreatoduodenectomy in benign, premalignant, and malignant disease.
Minimally invasive versus open pancreatoduodenectomy in benign, premalignant, and malignant disease. Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of laparoscopic or robot-assisted pancreatoduodenectomy versus open pancreatoduodenectomy for people with benign, prem…
View article: MicroRNAs as Bile-based biomarkers in pancreaticobiliary cancers (MIRABILE): a cohort study
MicroRNAs as Bile-based biomarkers in pancreaticobiliary cancers (MIRABILE): a cohort study Open
Background: Biliary obstruction can be due to both malignant and benign pancreaticobiliary disease. Currently, there are no biomarkers that can accurately help make this distinction. MicroRNAs (miRNAs) are stable molecules in tissue and bi…
View article: Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN): Clinicopathological Features, Recurrence and Response to Adjuvant Chemotherapy
Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN): Clinicopathological Features, Recurrence and Response to Adjuvant Chemotherapy Open
Background The clinico-oncological outcomes of precursor epithelial subtypes of adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN) are limited to small cohort studies. Differences in recurrence patterns and respo…
Tube2FEM: a general-purpose highly-automated pipeline for flow related processes in (embedded) tubular objects Open
This paper presents a comprehensive and highly-automated open-source pipeline for simulating flow and flow-related processes in (embedded) tubular structures. Addressing a critical gap in computational fluid dynamics (CFD) and simulation s…
View article: Competing for pixels: a self-play algorithm for weakly-supervised segmentation
Competing for pixels: a self-play algorithm for weakly-supervised segmentation Open
Weakly-supervised segmentation (WSS) methods, reliant on image-level labels indicating object presence, lack explicit correspondence between labels and regions of interest (ROIs), posing a significant challenge. Despite this, WSS methods h…
NGAL in the Development of Acute Kidney Injury in a Murine Model of Remote Ischaemic Preconditioning and Liver Ischaemia Reperfusion Open
Acute kidney injury (AKI) is common following liver transplantation and is associated with liver ischeamia reperfusion (IR) injury. The purpose of this study was to use a mouse model of liver IR injury and AKI to study the role of Neutroph…
View article: Cytoreductive surgery plus hyperthermic intraoperative peritoneal chemotherapy for people with peritoneal metastases from colorectal, ovarian or gastric origin: A systematic review of randomized controlled trials
Cytoreductive surgery plus hyperthermic intraoperative peritoneal chemotherapy for people with peritoneal metastases from colorectal, ovarian or gastric origin: A systematic review of randomized controlled trials Open
Background There is uncertainty in the relative benefits and harms of hyperthermic intraoperative peritoneal chemotherapy (HIPEC) when added to cytoreductive surgery (CRS) +/− systemic chemotherapy or systemic chemotherapy alone in people …
View article: Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for distal cholangiocarcinoma: An international multicentre retrospective cohort study
Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for distal cholangiocarcinoma: An international multicentre retrospective cohort study Open
Two thirds of patients have cancer recurrence following pancreaticoduodenectomy for dCCA, and most recur within three years of surgery. The commonest sites of recurrence are the pancreatic bed, liver and lung. Multiple histological feature…
View article: Active learning using adaptable task-based prioritisation
Active learning using adaptable task-based prioritisation Open
Supervised machine learning-based medical image computing applications necessitate expert label curation, while unlabelled image data might be relatively abundant. Active learning methods aim to prioritise a subset of available image data …
View article: Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study
Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study Open
Background The clinical impact of adjuvant chemotherapy after resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia is unclear. The aim of this study was to identify factors related to receipt of adjuvant chemo…
View article: Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy? Results from an international multicentre study
Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy? Results from an international multicentre study Open
A considerable number of patients who had an uneventful recovery received PN. PN is not without risk, and should be reserved for those who are unable to take an oral diet. PD patients should undergo pre- and postoperative assessment by nut…
HPB P29 Improving the management of pain and cachexia in pancreatic cancer: Development of a patient-centred evidence-based pathway Open
Background Incidence of pancreatic cancer is increasing worldwide and is likely to become the third commonest cause of cancer death in UK by 2030. Approximately 75% of people with pancreatic cancer suffer with pain and over 50% have cachex…