Pierre Dubus
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View article: The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a <scp>HIF2A</scp> ‐Dependent Upregulation and a <scp>FURIN</scp> ‐Dependent Cleavage of the <scp>ANGPTL4</scp> Secreted Factor
The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a <span>HIF2A</span> ‐Dependent Upregulation and a <span>FURIN</span> ‐Dependent Cleavage of the <span>ANGPTL4</span> Secreted Factor Open
Senescent cells are characterized by a stable proliferation arrest and a senescence‐associated secretory phenotype or SASP. Although these cells can have some beneficial effects, including protecting from tumor formation, their accumulatio…
View article: Association Between <scp>CD147</scp> Expression, <i>RAS</i> Mutational Status, and Local Recurrence in Resected Locally Advanced Rectal Cancer
Association Between <span>CD147</span> Expression, <i>RAS</i> Mutational Status, and Local Recurrence in Resected Locally Advanced Rectal Cancer Open
Aim About 5% to 10% of rectal cancer (RC) patients experience local disease recurrence after chemoradiotherapy (CRT) and surgery. Identifying patients at high risk of local recurrence (LR) could lead to the personalized management of the p…
View article: DNA methylation protects cancer cells against senescence
DNA methylation protects cancer cells against senescence Open
Inhibitors of DNA methylation such as 5-aza-deoxycytidine are widely used in experimental and clinical settings. However, their mechanism of action is such that DNA damage inevitably co-occurs with loss of DNA methylation, making it challe…
View article: Chronic Infection With Gastric <i>Helicobacters</i> Induces Hepatic Lesions in Mice
Chronic Infection With Gastric <i>Helicobacters</i> Induces Hepatic Lesions in Mice Open
Background Helicobacter pylori infection is one of the most prevalent chronic bacterial infections worldwide. This bacillus colonizes the human stomach lifelong, where it induces chronic gastritis, evolving in some cases to gastro‐duodenal…
View article: Recurrent primary cutaneous marginal zone lymphoma: a comparative study of initial tumours, recurrences, and outcomes in 61 patients
Recurrent primary cutaneous marginal zone lymphoma: a comparative study of initial tumours, recurrences, and outcomes in 61 patients Open
Aims Primary cutaneous marginal zone lymphoma (PCMZL) is considered a lymphoproliferative disorder (International Consensus Classification, ICC) or an overt lymphoma (WHO‐HAEM5). Seeking evidence for a reactive process or true lymphoma, we…
View article: DNA methylation protects cancer cells against senescence
DNA methylation protects cancer cells against senescence Open
Inhibitors of DNA methylation such as 5-aza-deoxycytidine are widely used in experimental and clinical settings. However, their mechanism of action is such that DNA damage inevitably co-occurs with loss of DNA methylation, making it challe…
View article: The “StemDif Sensor Test”: A Straightforward, Non-Invasive Assay to Characterize the Secreted Stemness and/or Differentiation Activities of Tumor-Derived Cancer Cell Lines
The “StemDif Sensor Test”: A Straightforward, Non-Invasive Assay to Characterize the Secreted Stemness and/or Differentiation Activities of Tumor-Derived Cancer Cell Lines Open
Cancer stem cells are a subpopulation of tumor cells characterized by their ability to self-renew, induce tumors upon engraftment in animals and exhibit strong resistance to chemotherapy and radiotherapy. These cells exhibit numerous chara…
View article: Supplementary Table 1 from Loss of the Methyl-CpG–Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis
Supplementary Table 1 from Loss of the Methyl-CpG–Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis Open
GO terms enriched in Zbtb4 -/- MEFs
View article: Supplementary Figure S6 from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer
Supplementary Figure S6 from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer Open
Figure S6 and legend
View article: Supplemental Figure 1 from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer
Supplemental Figure 1 from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer Open
Schematic representation of the IL-17A and REG3β signaling pathway and PDAC development.
View article: Tables S1-S3 from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
Tables S1-S3 from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer Open
Primers used for genotyping (Table S1) and RT-PCR (Table S2), and list of antibodies (Table S3)
View article: Data from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer
Data from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) offers an optimal model for discovering “druggable” molecular pathways that participate in inflammation-associated cancer development. Chronic pancreatitis, a common prolonged inflammatory disease, b…
View article: Supplementary Figure 1 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 1 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Detection of cells expressing CD44 and ALDH activity in gastric tumorspheres in vitro.
View article: Data from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer
Data from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) offers an optimal model for discovering “druggable” molecular pathways that participate in inflammation-associated cancer development. Chronic pancreatitis, a common prolonged inflammatory disease, b…
View article: Supplementary Table 1 from Loss of the Methyl-CpG–Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis
Supplementary Table 1 from Loss of the Methyl-CpG–Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis Open
GO terms enriched in Zbtb4 -/- MEFs
View article: Supplementary Figure 4 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 4 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Effect of verapamil treatment in combination with chemotherapies on tumorsphere formation by GC10.
View article: Supplementary Figure S1 from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer
Supplementary Figure S1 from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer Open
Figure S1 and legend
View article: Supplementary Figure 3 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary Figure 3 from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Effect of verapamil treatment in combination with dose-dependent chemotherapies on gastric cancer cell lines viability.
View article: Data from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Data from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Purpose: Gastric carcinomas are heterogeneous, and the current therapy remains essentially based on surgery with conventional chemotherapy and radiotherapy. This study aimed to characterize biomarkers allowing the detection of cancer stem …
View article: Figures S4 & S5 from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
Figures S4 & S5 from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer Open
Lung metastatis burden (Fig. S4) and CTCs content (Fig. S5) in 14-weeks PyMT mice with deregulated Loxl2
View article: Data from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
Data from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer Open
The lysyl oxidase–like protein LOXL2 has been suggested to contribute to tumor progression and metastasis, but in vivo evidence has been lacking. Here we provide functional evidence that LOXL2 is a key driver of breast cancer metastasis in…
View article: Supplementary Figure S3 from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer
Supplementary Figure S3 from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer Open
Figure S3 and legends
View article: Supplementary materials from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma
Supplementary materials from Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma Open
Supplementary experimental procedures,figure legends and references
View article: Supplemental Figure 1 from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer
Supplemental Figure 1 from IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer Open
Schematic representation of the IL-17A and REG3β signaling pathway and PDAC development.
View article: Supplementary Data from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer
Supplementary Data from E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer Open
Supplementary Methods and Supplementary Tables S1-S4
View article: Supplementary Figures 1 through 6 from Loss of the Methyl-CpG–Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis
Supplementary Figures 1 through 6 from Loss of the Methyl-CpG–Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis Open
Figure S1. Controls related to Figure 1. Figure S2. Illustrations and controls related to Figure 2. Figure S3. Controls related to Figure 3. Figure S4. Additional data related to Figure 4. Figure S5. Additional data related to Figure 5. Fi…
View article: Supplementary information from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
Supplementary information from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer Open
Suppplementary Material and Methods and related references