Bo Eric Beuthner
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View article: Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis
Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis Open
Aims Epicardial adipose tissue (EAT) is closely associated with the development of heart failure and adverse myocardial remodelling. In patients with severe aortic valve stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR…
View article: Cardiovascular MRI–derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis
Cardiovascular MRI–derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis Open
Cardiac MRI–derived imaging markers demonstrated significant prognostic value in individuals with severe aortic stenosis, with right atrial strain independently predicting cardiovascular mortality and enabling identification of additional …
View article: Cellular and extracellular proteomic profiling of paradoxical low-flow low-gradient aortic stenosis myocardium
Cellular and extracellular proteomic profiling of paradoxical low-flow low-gradient aortic stenosis myocardium Open
Aims Patients with severe aortic stenosis (AS), low transvalvular flow (LF) and low gradient (LG) with normal ejection fraction (EF)—are referred to as paradoxical LF-LG AS (PLF-LG). PLF-LG patients develop more advanced heart failure symp…
View article: Single-nucleus transcriptomics reveals adrenergic and STAT3 signalling in paradoxical low-flow low-gradient-specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment
Single-nucleus transcriptomics reveals adrenergic and STAT3 signalling in paradoxical low-flow low-gradient-specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment Open
Journal Article Accepted manuscript Single-nucleus transcriptomics reveals adrenergic and STAT3 signaling in paradoxical low-flow low-gradient -specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment…
View article: Cardiac fibrosis as a predictor for sudden cardiac death after transcatheter aortic valve implantation
Cardiac fibrosis as a predictor for sudden cardiac death after transcatheter aortic valve implantation Open
The burden of diffuse cardiac fibrosis plays an important and independent prognostic role regarding SCD early after TAVI. Therefore, the histological evaluation of fibrosis topography has value as a prognostic tool for TAVI patients and ma…
View article: Histological assessment of cardiac amyloidosis in patients undergoing transcatheter aortic valve replacement
Histological assessment of cardiac amyloidosis in patients undergoing transcatheter aortic valve replacement Open
Aims Studies have reported a strongly varying co‐prevalence of aortic stenosis (AS) and cardiac amyloidosis (CA). We sought to histologically determine the co‐prevalence of AS and CA in patients undergoing transcatheter aortic valve replac…
View article: Epicardial adipose tissue as an independent predictor of long-term outcome in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
Epicardial adipose tissue as an independent predictor of long-term outcome in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement Open
Background Accurate risk stratification is important to improve patient selection and outcome of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). As epicardial adipose tissue (EAT) is disc…
View article: Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function
Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function Open
Background Patients with severe aortic stenosis (AS) and reduced left ventricular ejection fraction (LVEF) can be distinguished into high- (HG) and low-gradient (LG) subgroups. However, less is known about their characteristics and underly…
View article: Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function
Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function Open
Background Patients with severe aortic stenosis (AS) and reduced left ventricular ejection fraction (LVEF) can be distinguished into high-(HG) and low-gradient (LG) subgroups. However, less is known about their characteristics and underlyi…
View article: Aortic valve calcification and myocardial fibrosis determine outcome following transcatheter aortic valve replacement
Aortic valve calcification and myocardial fibrosis determine outcome following transcatheter aortic valve replacement Open
Aims There is evidence to suggest that the subtype of aortic stenosis (AS), the degree of myocardial fibrosis (MF), and level of aortic valve calcification (AVC) are associated with adverse cardiac outcome in AS. Because little is known ab…
View article: Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis
Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis Open
Severe aortic stenosis (AS) is a common pathological condition in an ageing population imposing significant morbidity and mortality. Based on distinct hemodynamic features, i.e., ejection fraction (EF), transvalvular gradient and stroke vo…
View article: Artificial Intelligence Enabled Fully Automated CMR Function Quantification for Optimized Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Replacement
Artificial Intelligence Enabled Fully Automated CMR Function Quantification for Optimized Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Replacement Open
Background. Cardiovascular magnetic resonance imaging is considered the reference standard for assessing cardiac morphology and function and has demonstrated prognostic utility in patients undergoing transcatheter aortic valve replacement …
View article: Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study
Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study Open
CMR imaging enables comprehensive detection of myocardial remodeling in patients undergoing TAVR. Regression of LV matrix volume as a surrogate for reversible diffuse myocardial fibrosis is accompanied by increase of myocardial function an…
View article: Transcatheter Treatment of Secondary Tricuspid Regurgitation With Direct Annuloplasty: Results From a Multicenter Real-World Experience
Transcatheter Treatment of Secondary Tricuspid Regurgitation With Direct Annuloplasty: Results From a Multicenter Real-World Experience Open
Background: Treatment options for secondary tricuspid regurgitation (TR) remain limited. Early real-world data of a new percutaneous direct annuloplasty system for tricuspid repair were examined. Methods: The first 60 patients treated with…
View article: Transient acute right coronary artery deformation during transcatheter interventional tricuspid repair with the Cardioband tricuspid system
Transient acute right coronary artery deformation during transcatheter interventional tricuspid repair with the Cardioband tricuspid system Open
RCA deformation is relatively frequent following interventional tricuspid annuloplasty but appears to be completely reversible in the absence of flow impairment or vascular damage. Based on our early experience watchful waiting is the most…
View article: Structural and functional reverse myocardial remodeling following transcatheter aortic valve replacement
Structural and functional reverse myocardial remodeling following transcatheter aortic valve replacement Open
Background Myocardial reverse remodeling determines outcome in patients with severe aortic stenosis (AS) following transcatheter aortic valve replacement (TAVR). However, little is known about the interplay of myocardial function and struc…
View article: Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of severe aortic stenosis
Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of severe aortic stenosis Open
Aims Myocardial fibrosis (MF) might represent a key player in pathophysiology of heart failure in aortic stenosis (AS). We aimed to assess its impact on left ventricular (LV) remodelling, recovery, and mortality after transcatheter aortic …
View article: Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement
Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement Open
The bioresource (>265 patients with >27,600 biospecimens until December 2019; recruitment ongoing) on severe aortic stenosis is of vital importance to improve the still incomplete understanding of its etiology as well as its transition to …
View article: Empagliflozin enhances human and murine cardiomyocyte glucose uptake by increased expression of GLUT1
Empagliflozin enhances human and murine cardiomyocyte glucose uptake by increased expression of GLUT1 Open
Abbreviations 2-DG 2-Deoxyglucose HF Heart failure SGLT2 Sodium-glucose cotransporter 2 TAC Transverse aortic constriction WT Wild-type To the Editor: The results of the Empagliflozin, Cardiovascular Outcome Event Trial in Type 2 Diabetes …
View article: Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure
Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure Open
Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohor…