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View article: Figure 3 from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
Figure 3 from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma Open
ATAC-seq and RNA-seq on murine omental tumor deposits. A, Number of ATAC-seq peaks for control (n = 6) and HKMTI-1–005 samples (n = 5), before applying filtration criteria. One HKMTI-1–005 sample did not yield enough s…
View article: Figure 4 from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
Figure 4 from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma Open
Dual G9A/EZH2 inhibition inhibits tumor growth and prolongs survival in a mouse ovarian cancer model. A, Experimental design for mechanism experiments. Mice bearing intraperitoneal Trp53−/−ID8 cells were treated wi…
View article: Figure 5 from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
Figure 5 from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma Open
Dual G9A/EZH2 inhibition changes intratumoral immune cell composition in a mouse ovarian cancer model. A, Quantitative result for NK cells (CD3− DX5+) cells in porta hepatis deposits with vehicle (n = 7)…
View article: Clinical validation of a <scp>DNA</scp> methylation biomarker associated with overall survival of relapsed ovarian cancer patients
Clinical validation of a <span>DNA</span> methylation biomarker associated with overall survival of relapsed ovarian cancer patients Open
Approximately 70% of ovarian cancer (OC) patients relapse after chemotherapy, underscoring the need to assess survival before second‐line treatment. We previously identified PLAT‐M8, an 8‐CpG blood‐based methylation signature linked to che…
View article: Correction to: Prostate cancer cell malignancy via modulation of HIF-1α pathway with isoflurane and propofol alone and in combination
Correction to: Prostate cancer cell malignancy via modulation of HIF-1α pathway with isoflurane and propofol alone and in combination Open
View article: G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells Open
Background Epigenetic evolution is a common mechanism used by cancer cells to evade the therapeutic effects of drug treatment. In ovarian cancers, epigenetically driven resistance is thought to be responsible for many late-stage patient de…
View article: Circulating immune cells exhibit distinct traits linked to metastatic burden in breast cancer
Circulating immune cells exhibit distinct traits linked to metastatic burden in breast cancer Open
Background Circulating immune cells play a crucial role in the anti-tumour immune response, yet the systemic immune system in metastatic breast cancers is not fully characterised. Investigating the cellular and molecular changes in periphe…
View article: Answering real-world clinical questions using large language model, retrieval-augmented generation, and agentic systems
Answering real-world clinical questions using large language model, retrieval-augmented generation, and agentic systems Open
Objective The practice of evidence-based medicine can be challenging when relevant data are lacking or difficult to contextualize for a specific patient. Large language models (LLMs) could potentially address both challenges by summarizing…
View article: Clinical Validation of a DNA Methylation Biomarker Associated with Overall Survival of Relapsed Ovarian Cancer Patients
Clinical Validation of a DNA Methylation Biomarker Associated with Overall Survival of Relapsed Ovarian Cancer Patients Open
View article: A revised understanding of the speciation of gold(<scp>iii</scp>) dithiocarbamate complexes in solution
A revised understanding of the speciation of gold(<span>iii</span>) dithiocarbamate complexes in solution Open
Contrary to the established orthodoxy, “pure” Au( iii ) dithiocarbamates actually exist as a solution-phase equilibrium with an ion pair.
View article: Clinical validation of a DNA methylation biomarker to predict overall survival of relapsed ovarian cancer patients
Clinical validation of a DNA methylation biomarker to predict overall survival of relapsed ovarian cancer patients Open
Background About 70% of ovarian cancer (OC) patients relapse after initial chemotherapy, making it crucial to predict survival before second-line treatment. Our previous work discovered a blood-based DNA methylation prognostic signature (P…
View article: Supplementary Video 1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Supplementary Video 1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Open
Key interactive capabilities of NG-CHMs
View article: Supplementary Figure S1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Supplementary Figure S1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Open
Figure showing the NG-CHM Generator in the Galaxy bioinformatics platform.
View article: Supplementary Video 2 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Supplementary Video 2 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Open
NG-CHMs within Galaxy
View article: Supplementary Figure S1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Supplementary Figure S1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Open
Figure showing the NG-CHM Generator in the Galaxy bioinformatics platform.
View article: Supplementary Video 2 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Supplementary Video 2 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Open
NG-CHMs within Galaxy
View article: Data from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Data from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Open
Clustered heatmaps are the most frequently used graphics for visualization of molecular profiling data in biology. However, they are generally rendered as static, or only modestly interactive, images. We have now used recent advances in we…
View article: Supplementary Video 1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Supplementary Video 1 from A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data Open
Key interactive capabilities of NG-CHMs
View article: G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer Open
Epigenetic evolution is a common mechanism used by cancer cells to evade the therapeutic effects of drug treatment. In ovarian cancers, epigenetically-driven resistance may be responsible for a large number of late-stage patient deaths. He…
View article: WCN24-1878 NephroEduHaiti: Strengthening Nephrology Resident Education in Haiti through international Video Conferencing
WCN24-1878 NephroEduHaiti: Strengthening Nephrology Resident Education in Haiti through international Video Conferencing Open
Nephrology education in Haiti faces numerous challenges due to limited resources and access to specialized training. With only 7 nephrologists serving a population of 11 million people, the scarcity of local expertise has hindered the deve…
View article: cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance
cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance Open
Aberrant cMYC activity is a key driver of cancer, involved in several hallmark processes. Alongside the canonical hallmark of proliferation, cMYC represses immune signalling in a cell-intrinsic manner. The histone methyltransferases EZH2 a…
View article: Soil erosion after fire in volcanic terrain: Assessment and implications for post-fire soil losses
Soil erosion after fire in volcanic terrain: Assessment and implications for post-fire soil losses Open
Wildfires can dramatically modify the hydrologic and erosion response of ecosystems, increasing risks to population and assets downslope of fire affected hillslopes. This applies especially to volcanic areas in fire-prone regions which oft…
View article: The James Webb Space Telescope Mission: Optical Telescope Element Design, Development, and Performance
The James Webb Space Telescope Mission: Optical Telescope Element Design, Development, and Performance Open
The James Webb Space Telescope (JWST) is a large, infrared space telescope that has recently started its science program which will enable breakthroughs in astrophysics and planetary science. Notably, JWST will provide the very first obser…
View article: Data from Biomarker Assessment of HR Deficiency, Tumor <i>BRCA1/2</i> Mutations, and <i>CCNE1</i> Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy
Data from Biomarker Assessment of HR Deficiency, Tumor <i>BRCA1/2</i> Mutations, and <i>CCNE1</i> Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy Open
The current study evaluated three biomarkers [homologous recombination deficiency (HRD), tumor BRCA1/2 (tBRCA) mutations, and CCNE1 copy-number variation (CNV)] in ovarian tumors from patients enrolled on the SCOTROC4 clinical trial for as…
View article: Supplementary Figure 1 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
Supplementary Figure 1 from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors Open
PDF file - 15423K, Heatmap of heirarchial clustering shown in Figure 1.
View article: Supplementary Table 2 from Ovarian Cancer Stem Cell–Like Side Populations Are Enriched Following Chemotherapy and Overexpress <i>EZH2</i>
Supplementary Table 2 from Ovarian Cancer Stem Cell–Like Side Populations Are Enriched Following Chemotherapy and Overexpress <i>EZH2</i> Open
Supplementary Table 2 from Ovarian Cancer Stem Cell–Like Side Populations Are Enriched Following Chemotherapy and Overexpress EZH2
View article: Data from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors
Data from Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors Open
Genetic abnormalities of cholangiocarcinoma have been widely studied; however, epigenomic changes related to cholangiocarcinogenesis have been less well characterized. We have profiled the DNA methylomes of 28 primary cholangiocarcinoma an…
View article: Supplementary Table from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
Supplementary Table from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma Open
Supplementary Table from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
View article: Supplementary Figure from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
Supplementary Figure from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma Open
Supplementary Figure from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
View article: Supplemental Figures 1-3 and Supplemental Tables 1-9 from Biomarker Assessment of HR Deficiency, Tumor <i>BRCA1/2</i> Mutations, and <i>CCNE1</i> Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy
Supplemental Figures 1-3 and Supplemental Tables 1-9 from Biomarker Assessment of HR Deficiency, Tumor <i>BRCA1/2</i> Mutations, and <i>CCNE1</i> Copy Number in Ovarian Cancer: Associations with Clinical Outcome Following Platinum Monotherapy Open
Supplemental Figure 1. Flow of patients and samples through study Supplemental Figure 2. Receiver operating curve (ROC) for HRD as a predictor of CA125 response in the HGSOC subset. Supplementary Table 1. Clinical characteristics and patie…