Alison Edelman
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View article: Genetic Variants in Recurrent Euploid Pregnancy Loss
Genetic Variants in Recurrent Euploid Pregnancy Loss Open
Recurrent pregnancy loss (RPL) affects ∼5% of women, yet the genetic basis of euploid losses remains unclear. We performed genome sequencing in 118 families with unexplained euploid RPL, most without fetal anomalies. We identified genomic …
View article: Brief report: Older adolescents and young adults may be at higher risk for changes to menstrual cycle length with COVID-19 vaccination
Brief report: Older adolescents and young adults may be at higher risk for changes to menstrual cycle length with COVID-19 vaccination Open
Existing research has consistently demonstrated that adult women experience a small temporary increase in menstrual cycle length following COVID-19 vaccination; however, less is known about whether these changes differ depending on age. Th…
View article: Over-the-Counter Oral Contraceptive Use and Initiation of Contraception
Over-the-Counter Oral Contraceptive Use and Initiation of Contraception Open
Importance The US Food and Drug Administration approved the first over-the-counter (OTC) oral contraceptive pill (OCP) in 2023, potentially expanding access to contraception. Understanding whether OTC availability reaches individuals with …
View article: The right to science in sexual and reproductive health and the legal status of the human embryo
The right to science in sexual and reproductive health and the legal status of the human embryo Open
Through the examination of scientific evidence related to human embryo development, the aim of this commentary is to support the right to science in sexual and reproductive health, to outline why science supports a legal approach to embryo…
View article: Menstrual Cycle Length Changes Following Vaccination Against Influenza Alone or With COVID-19
Menstrual Cycle Length Changes Following Vaccination Against Influenza Alone or With COVID-19 Open
Importance Multiple studies have identified an association between COVID-19 vaccination and menstrual disturbances. Data on whether menstrual health is impacted by other vaccines are needed to counsel individuals about what to expect and t…
View article: Uses of ulipristal acetate beyond emergency contraception: A narrative review
Uses of ulipristal acetate beyond emergency contraception: A narrative review Open
Ulipristal acetate (UPA) has shown significant promise for indications outside of EC, including uterine leiomyomas, prevention and treatment of breast cancer, and abnormal uterine bleeding. Access to UPA is crucial not only for EC but for …
View article: Consensus recommendations for measuring the impact of contraception on the menstrual cycle in contraceptive clinical trials
Consensus recommendations for measuring the impact of contraception on the menstrual cycle in contraceptive clinical trials Open
Consensus recommendations on measuring bleeding changes and related outcomes in contraceptive clinical trials can improve reporting of standardized, patient-centered outcomes in future product labeling. These improvements can enable health…
View article: Association between menstrual cycle pattern regularity and changes in menstrual bleeding following COVID-19 vaccination: secondary analysis of an observational study
Association between menstrual cycle pattern regularity and changes in menstrual bleeding following COVID-19 vaccination: secondary analysis of an observational study Open
International audience
View article: Risk of fracture in users of hormonal contraception
Risk of fracture in users of hormonal contraception Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of hormonal contraception used for pregnancy prevention on fracture risk in individuals who are currently or were previously capa…
View article: OR24-01 Time to Sperm Suppression With Daily Transdermal Use of Nestorone and Testosterone Combination Gel for Male Contraception Is Faster Than Expected
OR24-01 Time to Sperm Suppression With Daily Transdermal Use of Nestorone and Testosterone Combination Gel for Male Contraception Is Faster Than Expected Open
D. Gross: None. C. Wang: None. S.T. Page: None. R. Sitruk-Ware: None. M. Creinin: None. R.A. Anderson: None. A. Edelman: None. D. Turok: None. J. Kinuthia: None. J. Vinay: None. K.T. Barnhart: None. K. Gemzell Danielsson: None. F. Mhlanga:…
View article: Double dosing ulipristal acetate emergency contraception for individuals with obesity: a randomised crossover trial
Double dosing ulipristal acetate emergency contraception for individuals with obesity: a randomised crossover trial Open
Objective To determine whether increasing the dose of ulipristal acetate (UPA)-containing emergency contraception (EC) improves pharmacodynamic outcomes in individuals with obesity. Study design We enrolled healthy, regularly-cycling, conf…
View article: Association between COVID-19 vaccination and menstruation: a state of the science review
Association between COVID-19 vaccination and menstruation: a state of the science review Open
Introduction Menstrual health is a key patient-reported outcome beyond its importance as a general indicator of health and fertility. However, menstrual function was not measured in the clinical trials of COVID-19 vaccines. The purpose of …
View article: Consensus recommendations for measuring the impact of contraception on the menstrual cycle in contraceptive clinical trials
Consensus recommendations for measuring the impact of contraception on the menstrual cycle in contraceptive clinical trials Open
Objective We sought to develop consensus recommendations for improved measurement of contraceptive-induced menstrual changes (CIMCs) in contraceptive clinical trials to build upon previous standardization efforts. Study Design We undertook…
View article: Timing of Coronavirus Disease 2019 (COVID-19) Vaccination and Effects on Menstrual Cycle Changes
Timing of Coronavirus Disease 2019 (COVID-19) Vaccination and Effects on Menstrual Cycle Changes Open
OBJECTIVE: To assess whether menstrual cycle timing (follicular or luteal phase) of coronavirus disease 2019 (COVID-19) vaccine administration is associated with cycle length changes. METHODS: We used prospectively collected (2021–2022) me…
View article: Local anaesthesia for pain control in first trimester surgical abortion
Local anaesthesia for pain control in first trimester surgical abortion Open
Evidence from this updated review indicates that a 20 mL 1% plain lidocaine PCB decreases pain during an abortion procedure. Evidence supports forgoing buffering lidocaine and a wait time between PCB injection and cervical dilation. A 1.5-…
View article: Associations Among Menstrual Cycle Length, Coronavirus Disease 2019 (COVID-19), and Vaccination
Associations Among Menstrual Cycle Length, Coronavirus Disease 2019 (COVID-19), and Vaccination Open
OBJECTIVE: To assess whether coronavirus disease 2019 (COVID-19) is associated with menstrual cycle length changes and, if so, how that compares with those undergoing vaccination or no event (control). METHODS: We conducted a retrospective…
View article: Red blood cell capacity of modern menstrual products: considerations for assessing heavy menstrual bleeding
Red blood cell capacity of modern menstrual products: considerations for assessing heavy menstrual bleeding Open
Background Heavy menstrual bleeding affects up to one third of menstruating individuals and has a negative impact on quality of life. The diagnosis of heavy menstrual bleeding is based primarily on history taking, which is highly dependent…
View article: Timing of COVID19 vaccination drives menstrual cycle changes
Timing of COVID19 vaccination drives menstrual cycle changes Open
COVID-19 vaccination temporarily lengthens the menstrual cycle. However, without knowing why this happens, we are limited in our ability to fully address ongoing concerns around menstrual health and COVID-19 vaccination. We assessed whethe…
View article: Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception
Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception Open
There are no comparative studies assessing risk of thromboembolism in COVID-19 patients who use hormonal contraception, which was the primary objective of this review. Very little evidence exists examining the risk of increased COVID-19 di…
View article: Treatment of unfavorable bleeding patterns in contraceptive implant users: a randomized clinical trial of curcumin
Treatment of unfavorable bleeding patterns in contraceptive implant users: a randomized clinical trial of curcumin Open
Daily use of curcumin did not improve bleeding patterns in users of the etonogestrel contraceptive implant experiencing frequent or prolonged bleeding patterns.
View article: Impact of coronavirus disease 2019 (COVID‐19) vaccination on menstrual bleeding quantity: An observational cohort study
Impact of coronavirus disease 2019 (COVID‐19) vaccination on menstrual bleeding quantity: An observational cohort study Open
Objective To assess whether coronavirus disease 2019 (COVID‐19) vaccination impacts menstrual bleeding quantity. Design Retrospective cohort. Setting Five global regions. Population Vaccinated and unvaccinated individuals with regular mens…
View article: Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception: a Cochrane systematic review
Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception: a Cochrane systematic review Open
Background The coronavirus disease COVID-19 is associated with an increased risk of thrombotic events. Individuals with COVID-19 using hormonal contraception could be at additional risk for thromboembolism, but evidence is sparse. Methods …
View article: Educational Intervention Among Adolescents and Young Adults on Emergency Contraception Options
Educational Intervention Among Adolescents and Young Adults on Emergency Contraception Options Open
Timely interventions are needed to empower youth with knowledge of EC options.
View article: Progestin intrauterine devices versus copper intrauterine devices for emergency contraception
Progestin intrauterine devices versus copper intrauterine devices for emergency contraception Open
We included only one relevant study (711 women); a randomized, controlled, non-inferiority trial comparing LNG-IUDs to Cu-IUDs for EC, with a one-month follow-up. With one study, the evidence was very uncertain for the difference in pregna…