Mary B. Chan‐Park
YOU?
Author Swipe
View article: An optimized cyclophosphamide-treated mouse model of <i>Mycobacterium abscessus</i> pulmonary infection
An optimized cyclophosphamide-treated mouse model of <i>Mycobacterium abscessus</i> pulmonary infection Open
Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the nee…
View article: A Near Infrared Fluorescent Nanosensor for Spatial and Dynamic Measurements of Auxin, Indole-3-Acetic Acid,<i>in Planta</i>
A Near Infrared Fluorescent Nanosensor for Spatial and Dynamic Measurements of Auxin, Indole-3-Acetic Acid,<i>in Planta</i> Open
Auxins, particularly indole-3-acetic acid (IAA), is a phytohormone critical for plant growth, development, and response to environmental stimuli. Despite its importance, there is a lack of species-independent sensors that allow direct and …
View article: A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria
A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria Open
Objectives The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. We …
View article: Membrane Potential-Dependent Uptake of Cationic Oligoimidazolium Mediates Bacterial DNA Damage and Death
Membrane Potential-Dependent Uptake of Cationic Oligoimidazolium Mediates Bacterial DNA Damage and Death Open
The treatment of bacterial infections is becoming increasingly challenging with the emergence of antimicrobial resistance. Thus, the development of antimicrobials with novel mechanisms of action is much needed.
View article: Correction: Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies
Correction: Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies Open
Correction for ‘Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies’ by Zhangyong Si et al. , Chem. Sci. , 2022, 13 , 345–364, https://doi.org/10.1039/D1SC05835E.
View article: Polyimidazolium Protects against an Invasive Clinical Isolate of Salmonella Typhimurium
Polyimidazolium Protects against an Invasive Clinical Isolate of Salmonella Typhimurium Open
Frequent outbreaks of Salmonella Typhimurium infection, in both animal and human populations and with the potential for zoonotic transmission, pose a significant threat to the public health sector. The rapid emergence and spread of more in…
View article: Polyimidazolium protects against an invasive clinical isolate of <i>Salmonella</i> Typhimurium
Polyimidazolium protects against an invasive clinical isolate of <i>Salmonella</i> Typhimurium Open
Frequent outbreaks of Salmonella Typhimurium infection in both the animal and human population with potential for zoonotic transmission pose a significant threat to the public health sector. The rapid emergence and spread of more invasive …
View article: Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies
Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies Open
This review surveys the structure–activity of advanced antimicrobial cationic polymers with low toxicity and high selectivity. Their uses as potentiating adjuvants and as antibiofilm agents are also covered.
View article: Enzyme- and Relative Humidity-Responsive Antimicrobial Fibers for Active Food Packaging
Enzyme- and Relative Humidity-Responsive Antimicrobial Fibers for Active Food Packaging Open
Active food packaging materials that are sustainable, biodegradable, and capable of precise delivery of antimicrobial active ingredients (AIs) are in high demand. Here, we report the development of novel enzyme- and relative humidity (RH)-…
View article: High-Density Three-Dimensional Network of Covalently Linked Nitric Oxide Donors to Achieve Antibacterial and Antibiofilm Surfaces
High-Density Three-Dimensional Network of Covalently Linked Nitric Oxide Donors to Achieve Antibacterial and Antibiofilm Surfaces Open
Bacterial colonization on biomedical devices often leads to biofilms that are recalcitrant to antibiotic treatment and the leading cause of hospital-acquired infections. We have invented a novel pretreatment chemistry for device surfaces t…
View article: Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics
Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics Open
Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually have low biocompatibility because of their hydrophobic moieties. Herein, we report a new biode…
View article: Cationic Glycosylated Block Co-β-peptide Acts on the Cell Wall of Gram-Positive Bacteria as Anti-biofilm Agents
Cationic Glycosylated Block Co-β-peptide Acts on the Cell Wall of Gram-Positive Bacteria as Anti-biofilm Agents Open
Antimicrobial resistance is a global threat. In addition to the emergence of resistance to last resort drugs, bacteria escape antibiotics killing by forming complex biofilms. Strategies to tackle antibiotic resistance as well as biofilms a…
View article: Smart nanomicelles with bacterial infection-responsive disassembly for selective antimicrobial applications
Smart nanomicelles with bacterial infection-responsive disassembly for selective antimicrobial applications Open
Electrostatic nanomicelles remain stable and biocompatible under physiological conditions, but readily burst and spill out cationic antimicrobial peptide to kill bacteria at infection sites.
View article: Designer broad-spectrum polyimidazolium antibiotics
Designer broad-spectrum polyimidazolium antibiotics Open
Significance We designed and synthesized antimicrobial compounds effective in killing pan-drug-resistant bacterial pathogens. These compounds have a large therapeutic window due to their low mammalian cell toxicity. A lead compound showed …
View article: The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices
The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices Open
Medical device contamination caused by microbial pathogens such as bacteria and fungi has posed a severe threat to the patients' health in hospitals. Due to the increasing resistance of pathogens to antibiotics, the efficacy of traditional…
View article: Precisely Structured Nitric-Oxide-Releasing Copolymer Brush Defeats Broad-Spectrum Catheter-Associated Biofilm Infections <i>In Vivo</i>
Precisely Structured Nitric-Oxide-Releasing Copolymer Brush Defeats Broad-Spectrum Catheter-Associated Biofilm Infections <i>In Vivo</i> Open
Gram-negative bacteria cannot be easily eradicated by antibiotics and are a major source of recalcitrant infections of indwelling medical devices. Among various device-associated infections, intravascular catheter infection is a leading ca…
View article: Steering protein and salt ad- and desorption by an electrical switch applied to polymer-coated electrodes
Steering protein and salt ad- and desorption by an electrical switch applied to polymer-coated electrodes Open
Although solid-phase chromatography is a well-established method for protein separation, chemically intensive and often costly regeneration steps are needed to make reuse of the adsorbent possible. Here, we demonstrate the use of electroch…
View article: Hierarchical Porous Carbon for High-Performance CapacitiveDesalination of Brackish Water
Hierarchical Porous Carbon for High-Performance CapacitiveDesalination of Brackish Water Open
Capacitive\ndeionization (CDI), as an energy-efficient and promising\nbrackish water desalination technique, has certain advantages over conventional methods\nsuch as thermal distillation, ultrafiltration, and reverse osmosis.\nHowever, CD…
View article: Fast-Bactericidal Effect of Polyion Complex Nanoparticles on Gram-Negative Bacteria
Fast-Bactericidal Effect of Polyion Complex Nanoparticles on Gram-Negative Bacteria Open
There is an urgent need for effective bactericidal agents for use in real commercial formulations because many old disinfectants, such as halogenated compounds, are now banned. Cationic polymers may have good bactericidal properties in pur…
View article: Enterococcus faecalis Adapts to Antimicrobial Conjugated Oligoelectrolytes by Lipid Rearrangement and Differential Expression of Membrane Stress Response Genes
Enterococcus faecalis Adapts to Antimicrobial Conjugated Oligoelectrolytes by Lipid Rearrangement and Differential Expression of Membrane Stress Response Genes Open
Conjugated oligoelectrolytes (COEs) are emerging antimicrobials with broad spectrum activity against Gram positive and Gram negative bacteria as well as fungi. Our previous in vitro evolution studies using Enterococcus faecalis grown in th…
View article: A Glycosylated Cationic Block Poly(β‐peptide) Reverses Intrinsic Antibiotic Resistance in All ESKAPE Gram‐Negative Bacteria
A Glycosylated Cationic Block Poly(β‐peptide) Reverses Intrinsic Antibiotic Resistance in All ESKAPE Gram‐Negative Bacteria Open
Carbapenem‐resistant Gram‐negative bacteria (GNB) are heading the list of pathogens for which antibiotics are the most critically needed. Many antibiotics are either unable to penetrate the outer‐membrane or are excluded by efflux mechanis…
View article: Issue Information
Issue Information Open
Part A is an international, interdisciplinary, Englishlanguage publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical …
View article: Biguanide-Derived Polymeric Nanoparticles Kill MRSA Biofilm and Suppress Infection <i>In Vivo</i>
Biguanide-Derived Polymeric Nanoparticles Kill MRSA Biofilm and Suppress Infection <i>In Vivo</i> Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of drug-resistant infections. Its propensity to develop biofilms makes it especially resistant to conventional antibiotics. We present a novel nanoparticle (NP) syst…
View article: Synthetic biohybrid peptidoglycan oligomers enable pan-bacteria-specific labeling and imaging: <i>in vitro</i> and <i>in vivo</i>
Synthetic biohybrid peptidoglycan oligomers enable pan-bacteria-specific labeling and imaging: <i>in vitro</i> and <i>in vivo</i> Open
Peptidoglycan oligomers have been derived from chitosan, using a top-down bio-hybrid strategy, as highly bacteria-specific substrates.
View article: Replication Data for: Enterococcus faecalis adapts to antimicrobial conjugated oligoelectrolytes by lipid rearrangement and differential expression of membrane stress response genes
Replication Data for: Enterococcus faecalis adapts to antimicrobial conjugated oligoelectrolytes by lipid rearrangement and differential expression of membrane stress response genes Open
Replication Data for publication: Enterococcus faecalis adapts to antimicrobial conjugated oligoelectrolytes by lipid rearrangement and differential expression of membrane stress response genes. Includes: RNA sequencing data: RAW reads RNA…