Beate I. Escher
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View article: The PrecisionTox chemical library: creation of a chemical collection to discover evolutionary conserved biomolecular signatures of toxicity.
The PrecisionTox chemical library: creation of a chemical collection to discover evolutionary conserved biomolecular signatures of toxicity. Open
The large number and diversity of chemicals currently in use present significant challenges in assessing their human and environmental health risks due to a paucity of toxicological data. To address this shortage, high-throughput screening…
View article: The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease Open
The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. END…
View article: The PrecisionTox chemical library: creation of a chemical collection to discover evolutionary conserved biomolecular signatures of toxicity
The PrecisionTox chemical library: creation of a chemical collection to discover evolutionary conserved biomolecular signatures of toxicity Open
The large number and diversity of chemicals currently in use present significant challenges in assessing their human and environmental health risks due to a paucity of toxicological data. To address this shortage, high-throughput screening…
View article: In vitro bioassays for quantifying mixture effects of organic micropollutants extracted from caged fish, water, and sediment
In vitro bioassays for quantifying mixture effects of organic micropollutants extracted from caged fish, water, and sediment Open
Fish are exposed to countless chemicals over their lifetime, with the totality of internal exposure termed the eco-exposome. In vitro bioassays can be used to complement targeted chemical analysis to quantify the mixture effects of chemica…
View article: Applying effect-based methods to evaluate the mixture effects of disinfection by-products and other chemicals in disinfected water
Applying effect-based methods to evaluate the mixture effects of disinfection by-products and other chemicals in disinfected water Open
View article: Determination of Chemical Mixtures in Environmental, Food, and Human Samples Using High-Resolution Mass Spectrometry-Based Suspect Screening Approaches
Determination of Chemical Mixtures in Environmental, Food, and Human Samples Using High-Resolution Mass Spectrometry-Based Suspect Screening Approaches Open
Chemical contaminants are widely dispersed in the environment in all its dimensions, posing significant public health problems. Comprehensive knowledge of these stressors is a prerequisite for assessing the associated risk and implementing…
View article: The use of diagnostic tools to assess the risks of chemicals to freshwater ecosystems: towards a unified evaluation framework
The use of diagnostic tools to assess the risks of chemicals to freshwater ecosystems: towards a unified evaluation framework Open
View article: Beyond Estrogenicity: A Comparative Assessment of Bisphenol A and Its Alternatives in In Vitro Assays Questions Safety of Replacements
Beyond Estrogenicity: A Comparative Assessment of Bisphenol A and Its Alternatives in In Vitro Assays Questions Safety of Replacements Open
Bisphenol A (BPA) is a well-known endocrine disruptor linked to numerous adverse health outcomes and was, therefore, banned in food-contact materials in the European Union. Numerous alternatives are now in commerce, but their health hazard…
View article: Discursive strategies and paths forward for EU chemical legislation: bridging German stakeholder narratives on pollution and competitiveness for the announced REACH revision
Discursive strategies and paths forward for EU chemical legislation: bridging German stakeholder narratives on pollution and competitiveness for the announced REACH revision Open
View article: Current emission vs. legacy organic pollutants: Assessing the extent to which the eco-exposome of caged fish reflects external exposure
Current emission vs. legacy organic pollutants: Assessing the extent to which the eco-exposome of caged fish reflects external exposure Open
The eco-exposome represents the totality of chemicals present in an organism. To understand how internal exposure of fish relates to chemicals originating from external media (water, sediment), we conducted a 21-d caging study using fathea…
View article: Sequential exposure to anoxic/oxic conditions leads to biotransformation and detoxification of sitagliptin in urban hyporheic zones
Sequential exposure to anoxic/oxic conditions leads to biotransformation and detoxification of sitagliptin in urban hyporheic zones Open
Pharmaceuticals are increasingly recognized as contaminants of concern in aquatic environments. Sitagliptin, an antidiabetic drug that carries a trifluoromethyl group, which is a precursor of the persistent trifluoroacetic acid, is excrete…
View article: Dissolved and particulate micropollutant mixtures in surface waters: in vitro and chemical assessment in Rio de Janeiro versus global trends
Dissolved and particulate micropollutant mixtures in surface waters: in vitro and chemical assessment in Rio de Janeiro versus global trends Open
View article: Comparison of absorption and excretion of test compounds in sucking versus chewing pests
Comparison of absorption and excretion of test compounds in sucking versus chewing pests Open
A critical understanding of how pests interact with active ingredients is essential for the development of new insect control solutions to maintain crop quality and quantity by reducing insect damage. Absorption of insecticides into insect…
View article: Assessing Modes of Toxic Action of Organic Cations in <i>In Vitro</i> Cell-Based Bioassays: the Critical Role of Partitioning to Cells and Medium Components
Assessing Modes of Toxic Action of Organic Cations in <i>In Vitro</i> Cell-Based Bioassays: the Critical Role of Partitioning to Cells and Medium Components Open
High-throughput cell-based bioassays can fulfill the growing need to assess the hazards and modes of toxic action (MOA) of ionic liquids (ILs). Although nominal concentrations (Cnom) are typically used in an in vitro
View article: Role of Suspended Particulate Matter for the Transport and Risks of Organic Micropollutant Mixtures in Rivers: A Comparison between Baseflow and High Discharge Conditions
Role of Suspended Particulate Matter for the Transport and Risks of Organic Micropollutant Mixtures in Rivers: A Comparison between Baseflow and High Discharge Conditions Open
The partition dynamics of organic micropollutants between water and suspended particulate matter (SPM) in riverine ecosystems differs between dry and wet weather, as demonstrated at two sites at the Ammer River, Germany. One site was impac…
View article: MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data
MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data Open
View article: Following the Mixtures of Organic Micropollutants with <i>In Vitro</i> Bioassays in a Large Lowland River from Source to Sea
Following the Mixtures of Organic Micropollutants with <i>In Vitro</i> Bioassays in a Large Lowland River from Source to Sea Open
Human-impacted rivers often contain a complex mixture of organic micropollutants, including pesticides, pharmaceuticals and industrial compounds, along with their transformation products. Combining chemical target analysis for exposure wit…
View article: A combination of high-throughput in vitro and in silico new approach methods for ecotoxicology hazard assessment for fish
A combination of high-throughput in vitro and in silico new approach methods for ecotoxicology hazard assessment for fish Open
Fish acute toxicity testing is used to inform environmental hazard assessment of chemicals. In silico and in vitro approaches have the potential to reduce the number of fish used in testing and increase the efficiency of generating data fo…
View article: EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable
EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable Open
The commitment to develop a roadmap for phasing out the use of animals for chemical safety assessments was part of the European Commission’s response to the European Citizens’ Initiative “Save Cruelty-Free Cosmetics – Commit to a Europe Wi…
View article: The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease Open
The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. END…
View article: Effect-Based Water Quality Assessment in an Urban Tributary under Base Flow and Storm Conditions
Effect-Based Water Quality Assessment in an Urban Tributary under Base Flow and Storm Conditions Open
View article: Effect of tunnel wash water treatment processes on trace elements, organic micropollutants, and biological effects
Effect of tunnel wash water treatment processes on trace elements, organic micropollutants, and biological effects Open
Tunnel wash water (TWW) contains high levels of trace elements and organic micropollutants, especially in the dissolved fraction. Discharge poses significant environmental risks. This field study aimed at improving conventional sedimentati…
View article: The mode of toxic action of ionic liquids: Narrowing down possibilities using high-throughput, in vitro cell-based bioassays
The mode of toxic action of ionic liquids: Narrowing down possibilities using high-throughput, in vitro cell-based bioassays Open
Growing concerns about the environmental impact of ionic liquids (ILs) have spurred research into their (eco)toxic effects, but studies on their mode of toxic action (MOA) still remain limited. However, understanding the MOA and identifyin…
View article: Neurotoxic mixture effects of chemicals extracted from blood of pregnant women
Neurotoxic mixture effects of chemicals extracted from blood of pregnant women Open
Human biomonitoring studies typically capture only a small and unknown fraction of the entire chemical universe. We combined chemical analysis with a high-throughput in vitro assay for neurotoxicity to capture complex mixtures of organic c…
View article: MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data
MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data Open
MLinvitroTox is an automated Python pipeline developed for high-throughput hazard-driven prioritization of toxicologically relevant features detected in complex environmental samples through nontarget high-resolution mass spectrometry (NTS…
View article: A guidance for the enrichment of micropollutants from wastewater by solid-phase extraction before bioanalytical assessment
A guidance for the enrichment of micropollutants from wastewater by solid-phase extraction before bioanalytical assessment Open
View article: Impact of Biotransformation on Internal Concentrations and Specificity Classification of Organic Chemicals in the Zebrafish Embryo (<i>Danio rerio</i>)
Impact of Biotransformation on Internal Concentrations and Specificity Classification of Organic Chemicals in the Zebrafish Embryo (<i>Danio rerio</i>) Open
Internal concentrations (ICs) are crucial for linking exposure to effects in the development of New Approach Methodologies. ICs of chemicals in aquatic organisms are primarily driven by hydrophobicity and modulated by biotransformation and…
View article: Author Correction: Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Author Correction: Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom Open
View article: Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations
Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations Open
Per- and polyfluoroalkyl substances (PFAS) may cause various deleterious health effects. Epidemiological studies have demonstrated associations between PFAS exposure and adverse neurodevelopmental outcomes. The cytotoxicity, neurotoxicity,…
View article: Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom Open