Bo Hedblad
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View article: GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes Open
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studi…
View article: Supplementary Table 1 from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males
Supplementary Table 1 from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males Open
PDF file - 61K
View article: Data from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males
Data from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males Open
Background: Tumor development requires angiogenesis, and antiangiogenesis has been introduced in the treatment of cancer patients; however, how the cardiovascular phenotype correlates with cancer risk remains ill-defined. Here, we h…
View article: Data from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males
Data from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males Open
Background: Tumor development requires angiogenesis, and antiangiogenesis has been introduced in the treatment of cancer patients; however, how the cardiovascular phenotype correlates with cancer risk remains ill-defined. Here, we h…
View article: Supplementary Table 1 from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males
Supplementary Table 1 from Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males Open
PDF file - 61K
View article: Association of Cardiometabolic Multimorbidity With Mortality
Association of Cardiometabolic Multimorbidity With Mortality Open
The prevalence of cardiometabolic multimorbidity is increasing.
View article: Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium
Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium Open
AimsOrthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, b…
View article: Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort
Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort Open
Our study shows an association between B-Pb concentrations and occurrence of atherosclerotic plaque in the carotid artery, adding evidence for an underlying pro-atherogenic role of lead in cardiovascular disease. Associations appeared to b…
View article: Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Study
Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Study Open
TPS 771: Diet and lifestyle, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background: Smoking is a strong risk factor for cardiovascular disease (CVD) and causes exposure to cadmium, which is a pro-atherosclerotic meta…
View article: Blood lead levels and risk of atherosclerosis in the carotid artery: Results from a Swedish cohort
Blood lead levels and risk of atherosclerosis in the carotid artery: Results from a Swedish cohort Open
PDS 63: Chemicals and metals: health effects, Exhibition Hall (PDS), Ground floor, August 27, 2019, 10:30 AM - 12:00 PM Background/Aim: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes.…
View article: Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Cohort Study
Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Cohort Study Open
View article: Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study
Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study Open
B-Cd in non-smokers was associated with eight potential plasma biomarkers of CVD and kidney injury. The results suggest pathways for the associations between B-Cd and CVD and kidney injury.
View article: GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes Open
View article: Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration
Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration Open
An affiliation for Moise Desvarieux is missing. In addition to affiliation #22, Moise Desvarieux is affiliated with: METHODS Core, Centre de Recherche Epidémiologie et Statistique Paris Sorbonne Cité (CRESS), Institut National de la Santé …
View article: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration
Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration Open
We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.
View article: Cadmium, Carotid Atherosclerosis, and Incidence of Ischemic Stroke
Cadmium, Carotid Atherosclerosis, and Incidence of Ischemic Stroke Open
Background Exposure to cadmium has been associated with carotid plaques, inflammation in carotid plaques, and increased risk of ischemic stroke. This study examined the separate and interacting effects of blood cadmium levels and carotid p…
View article: Complement C3 Associates With Incidence of Diabetes, but No Evidence of a Causal Relationship
Complement C3 Associates With Incidence of Diabetes, but No Evidence of a Causal Relationship Open
Plasma concentration of C3 is a risk marker for incidence of diabetes. The results suggest that this association could, in part, be explained by pleiotropic effects related to the GCKR gene.
View article: Partial Mediation by Cadmium Exposure of the Association Between Tobacco Smoking and Atherosclerotic Plaques in the Carotid Artery
Partial Mediation by Cadmium Exposure of the Association Between Tobacco Smoking and Atherosclerotic Plaques in the Carotid Artery Open
Exposure to cadmium confers increased cardiovascular risk. Tobacco smoke contains cadmium, which, hypothetically, may mediate parts of the tobacco-associated risk of developing atherosclerotic plaques. Baseline data from the Swedish Malmö …
View article: The tyranny of the averages and the indiscriminate use of risk factors in public health: The case of coronary heart disease
The tyranny of the averages and the indiscriminate use of risk factors in public health: The case of coronary heart disease Open
View article: Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment
Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment Open
View article: Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study
Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study Open
In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.
View article: ST segment depression on 24-hour electrocardiography predicts incident atrial fibrillation in two population-based cohorts
ST segment depression on 24-hour electrocardiography predicts incident atrial fibrillation in two population-based cohorts Open
ST-depression at 24h-ECG is independently associated with incident AF, and incidence is substantially lower in individuals with neither ST-depression or high SVA. 24hECG can be used not only to diagnose AF but also to identify individuals …
View article: Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study
Clustering of cardiovascular risk factors and carotid intima-media thickness: The USE-IMT study Open
Clusters of risk factors relate to increased common CIMT in a graded manner, similar in men, women and across race-ethnic groups. Some clusters seemed more atherogenic than others. Our findings support the notion that cardiovascular preven…
View article: Cadmium exposure is associated with soluble urokinase plasminogen activator receptor, a circulating marker of inflammation and future cardiovascular disease
Cadmium exposure is associated with soluble urokinase plasminogen activator receptor, a circulating marker of inflammation and future cardiovascular disease Open
Exposure to cadmium was associated with increased plasma suPAR in the general population, independently of smoking and cardiovascular disease. These results imply that cadmium is a possible cause for raised levels of this inflammatory mark…
View article: Acute-phase proteins and incidence of diabetes: a population-based cohort study
Acute-phase proteins and incidence of diabetes: a population-based cohort study Open
View article: Carotenoids and alkylresorcinols as objective biomarkers of diet quality when assessing the validity of a web-based food record tool and a food frequency questionnaire in a middle-aged population
Carotenoids and alkylresorcinols as objective biomarkers of diet quality when assessing the validity of a web-based food record tool and a food frequency questionnaire in a middle-aged population Open
BACKGROUND: Recently, two web-based dietary assessment tools were developed; a 4-day food record tool (the Riksmaten method), and a food frequency questionnaire (MiniMeal-Q). The aim of this study was to use objective biomarkers to examine…
View article: Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort
Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort Open
Our study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer.
View article: Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort
Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort Open
View article: Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort
Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort Open
Low-level lead exposure increases blood pressure and may increase the risk of hypertension.
View article: Diet Quality and Change in Blood Lipids during 16 Years of Follow-up and Their Interaction with Genetic Risk for Dyslipidemia
Diet Quality and Change in Blood Lipids during 16 Years of Follow-up and Their Interaction with Genetic Risk for Dyslipidemia Open
A high diet quality according to the Swedish nutrition recommendations is associated with a reduced risk of cardiovascular disease in the population-based Malmö Diet and Cancer cohort. To further clarify this protective association, we exa…