Explanipedia

Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays Open

Zixuan Lu, Jeremy Treiber, Konstantinos Kallitsis, Ekaterina Selivanovitch, Alexandra Wheeler , et al. · 2025

Most virus infection assays have indirect readout such as virus number following entry (e.g., PCR, cell lysis). While effective, these technologies are labor‐intensive, require specialized environments (e.g., sterile or RNA‐free), and dete…

Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons (Adv. Sci. 27/2024) Open

Zixuan Lu, Chiara Barberio, Ana Fernández‐Villegas, Aimee Withers, Alexandra Wheeler , et al. · 2024

Neuronal‐Membrane‐on‐Chip The cover highlights a novel platform of interfacing cell membranes derived from primary neurons with organic microelectrode arrays for monitoring ion channel activities at natively‐expressed levels. In article nu…

Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons Open

Zixuan Lu, Chiara Barberio, Ana Fernández‐Villegas, Aimee Withers, Alexandra Wheeler , et al. · 2023

Drug studies targeting neuronal ion channels are crucial to understand neuronal function and develop therapies for neurological diseases. The traditional method to study neuronal ion‐channel activities heavily relies on the whole‐cell patc…

Threat Agnostic Virulence Assessment of Pathogens Open

Becky Hess, Lisa Bramer, Trinidad Alfaro · 2023

Virulence assessment of new, emerging, and engineered pathogens is critical to mounting an appropriate response to a biothreat agent. The capacity of the pathogen to colonize human and harm tissues must be characterized to understand patho…

High-throughput functional trait testing for bacterial pathogens Open

Zachary R. Stromberg, Shelby M. B. Phillips, Kristin M. Omberg, Becky Hess · 2023

Functional traits are characteristics that affect the fitness and metabolic function of a microorganism. There is growing interest in using high-throughput methods to characterize bacterial pathogens based on functional virulence traits. T…

Gene-matched enrichment and polymerase chain reaction for rapid detection of microorganisms Open

Richard M. Ozanich, Janine R. Hutchison, Kristin D. Victry, Becky Hess · 2023

A method for amplifying and detecting microorganisms, such as species of Listeria, is described. The method utilizes gene-matched enrichment media and PCR-based detection. The enrichment media is spent media produced using a modified micro…

Spent enrichment media for growth of gene-matched microorganisms Open

Richard M. Ozanich, Janine R. Hutchison, Kristin D. Victry, Becky Hess · 2023

A method for amplifying and detecting microorganisms, such as species of Listeria, is described. The method utilizes gene-matched enrichment media and PCR-based detection. The enrichment media is spent media produced using a modified micro…

Data for EMSL Project 60276 from January 2023 Open

Becky Hess · 2023

Engineering Citrobacter freundii using CRISPR/Cas9 system Open

Trinidad Alfaro, Joshua R. Elmore, Zachary R. Stromberg, Janine R. Hutchison, Becky Hess · 2022

The CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR associated proteins) system is a useful tool to edit genomes quickly and efficiently. However, the use of CRISPR/Cas9 to edit bacterial genomes has been limi…

Engineered Cell Line Imaging Assay Differentiates Pathogenic from Non-Pathogenic Bacteria Open

Shelby M. B. Phillips, Carson Bergstrom, Brian Walker, George Wang, Trinidad Alfaro , et al. · 2022

Cell culture systems have greatly expanded our understanding of how bacterial pathogens target signaling pathways to manipulate the host and cause infection. Advances in genetic engineering have allowed for the creation of fluorescent prot…

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from February 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from February 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from March 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from February 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from March 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from March 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from October 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from February 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from March 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from April 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from November 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from February 2022 Open

Becky Hess · 2022

Data for EMSL Project 60276 from February 2022 Open

Becky Hess · 2022

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