Frank B. Hu
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View article: Plasma metabolomic signature of breastfeeding and risk of cardiometabolic diseases
Plasma metabolomic signature of breastfeeding and risk of cardiometabolic diseases Open
Breastfeeding is inversely associated with cardiometabolic disease incidence in prospective studies; however, the metabolic pathways underlying these associations remain largely unknown. Here, we derive a plasma metabolomic score of lifeti…
View article: Multi-fluid, multi-omics signatures of insulin resistance and incident type 2 diabetes among Puerto Rican adults
Multi-fluid, multi-omics signatures of insulin resistance and incident type 2 diabetes among Puerto Rican adults Open
Introduction Previous studies have examined the prediction of insulin resistance and type 2 diabetes (T2D) using plasma or saliva omics, but none have combined metabolomics and proteomics from multiple biofluids, such as plasma and saliva.…
View article: Planetary Health Diet and Risk of Cardiometabolic Diseases Among Women With Gestational Diabetes
Planetary Health Diet and Risk of Cardiometabolic Diseases Among Women With Gestational Diabetes Open
Importance The Planetary Health Diet (PHD) integrates health and environmental sustainability, yet its association with chronic disease outcomes remains underexplored, particularly among women with a history of gestational diabetes (GD), w…
View article: A transposon insertion in the 5′ UTR of OsPT1 reprograms its expression pattern and promotes cadmium accumulation in rice grains
A transposon insertion in the 5′ UTR of OsPT1 reprograms its expression pattern and promotes cadmium accumulation in rice grains Open
Cadmium (Cd) accumulation in rice grains presents a serious risk to human health; however, the mechanisms underlying this process remain incompletely understood. In this study, a genome-wide association analysis identified 29 loci associat…
View article: The value of combined thromboelastography test for the early prediction of disease severity in patients with haemorrhagic fever of renal syndrome and the construction of a critical model
The value of combined thromboelastography test for the early prediction of disease severity in patients with haemorrhagic fever of renal syndrome and the construction of a critical model Open
Background Thromboelostograms (TEG) are indicators that reflect the dynamic changes in blood coagulation objectively. Compared with traditional coagulation tests, TEG are easy to perform; imparting a head start in determining patients’coag…
View article: Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function Open
Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) have a substantial genetic basis, with APOE4 homozygotes increasingly recognized as a distinct genetic subtype. To identify genotype-specific metabolic pathways and modifiable ris…
View article: Dietary Patterns, Circulating Metabolome, and Risk of Type 2 Diabetes
Dietary Patterns, Circulating Metabolome, and Risk of Type 2 Diabetes Open
Circulating metabolites may reflect biological homeostasis and have been linked to dietary intakes and human health, and may hold the promises to facilitate objective assessments of intakes and metabolic response to diets. Here, we integra…
View article: Total and specific potato intake and risk of type 2 diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts
Total and specific potato intake and risk of type 2 diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts Open
Objectives To investigate the associations between total and individual potato intake and risk of type 2 diabetes (T2D), estimate the effect on T2D risk of replacing potatoes with whole grains and other major carbohydrate sources, and cond…
View article: Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos
Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos Open
BACKGROUND & AIMS: Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain. METHODS: In 10 385 US Hispanics/Latinos from the Hispanic Com…
View article: Pre-pregnancy inflammatory and insulinemic dietary patterns and risk of gestational diabetes mellitus: a prospective cohort study of 14,674 women
Pre-pregnancy inflammatory and insulinemic dietary patterns and risk of gestational diabetes mellitus: a prospective cohort study of 14,674 women Open
In a large US cohort of predominantly White women, higher intake of pro-inflammatory and hyperinsulinemic diets was associated with increased risk of GDM. Further studies are warranted to confirm our findings, to provide evidence promoting…
View article: The Gut Microbiome Modifies the Association Between a Mediterranean Diet and Diabetes in USA Hispanic/ Latino Population
The Gut Microbiome Modifies the Association Between a Mediterranean Diet and Diabetes in USA Hispanic/ Latino Population Open
CONTEXT: The interrelationships among the gut microbiome, the Mediterranean diet (MedDiet), and a clinical endpoint of diabetes is unknown. OBJECTIVE: To identify gut microbial features of a MedDiet and examine whether the association betw…
View article: Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances
Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances Open
Over the past 3 decades, substantial evidence has accumulated to strongly support the benefits of the MedDiet in preventing chronic diseases and promoting healthy aging. Despite robust evidence, further studies are needed to evaluate the l…
View article: Mediating Effect of Established Risk Factors on Association Between Social Determinants and Cardiovascular Disease Mortality
Mediating Effect of Established Risk Factors on Association Between Social Determinants and Cardiovascular Disease Mortality Open
Behavioral and clinical risk factors partially mediate the association between unfavorable SDOH and increased CVD mortality.
View article: Multi-omics approach identifies gut microbiota variations associated with depression
Multi-omics approach identifies gut microbiota variations associated with depression Open
The gut microbiota plays a potential role in the pathophysiology of depression through the gut-brain axis. This cross-sectional study in 400 participants from the PREDIMED-Plus study investigates the interplay between gut microbiota and de…
View article: ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease
ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease Open
Background and Aims Apolipoprotein B concentration reflects the number of atherogenic lipoproteins and is recognized as a key lipid risk marker. Whether the type or size of apoB particle (apoB-P) adds predictive value for coronary artery d…
View article: LACE-UP: An ensemble machine-learning method for health subtype classification on multidimensional binary data
LACE-UP: An ensemble machine-learning method for health subtype classification on multidimensional binary data Open
Disease and behavior subtype identification is of significant interest in biomedical research. However, in many settings, subtype discovery is limited by a lack of robust statistical clustering methods appropriate for binary data. Here, we…
View article: The link between ultra-processed food consumption, fecal microbiota, and metabolomic profiles in older mediterranean adults at high cardiovascular risk
The link between ultra-processed food consumption, fecal microbiota, and metabolomic profiles in older mediterranean adults at high cardiovascular risk Open
ISRCTN89898870 ( https://doi.org/10.1186/ISRCTN89898870 ).
View article: Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity
Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity Open
Type 2 innate lymphoid cells (ILC2s) regulate the proliferation of preadipocytes that give rise to beige adipocytes. Whether and how ILC2 downstream Th2 cytokines control beige adipogenesis remain unclear. We used cell systems and genetic …
View article: Sleep Characteristics and Long-Term Risk of Type 2 Diabetes Among Women With Gestational Diabetes
Sleep Characteristics and Long-Term Risk of Type 2 Diabetes Among Women With Gestational Diabetes Open
Importance Women with a history of gestational diabetes (GD) are at high risk for developing type 2 diabetes (T2D). Sleep is a crucial lifestyle factor associated with cardiometabolic health, yet studies on its role in the progression from…
View article: Changes in olive oil consumption and long-term body weight changes in 3 United States prospective cohort studies
Changes in olive oil consumption and long-term body weight changes in 3 United States prospective cohort studies Open
A long-term increase in olive oil intake was inversely associated with body weight in middle-aged adults in the United States. Conversely, increased consumption of other added fats, such as butter and margarine, was positively associated w…