Billy G. Hudson
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View article: Targeted incorporation of collagen IV to the basement membrane: A step forward for developing extracellular protein therapies
Targeted incorporation of collagen IV to the basement membrane: A step forward for developing extracellular protein therapies Open
The collagen IV scaffold serves as a fundamental structural unit of the basement membrane (BM). Understanding its structure, assembly, and function is essential for tissue engineering, the design of organoid models, and developing therapie…
View article: Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution, and adaptation
Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution, and adaptation Open
Collagen IV (Col-IV) is a major component of basement membranes, a specialized form of extracellular matrix that enabled the assembly of multicellular epithelial tissues. In mammals, Col-IV assembles from a family of six α-chains (α1-α6), …
View article: Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling animal evolution and adaptation
Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling animal evolution and adaptation Open
Collagen IV is a major component of basement membranes, a specialized form of extracellular matrix that enabled the assembly of multicellular epithelial tissues. In mammals, collagen IV assembles from a family of six α-chains (α1 to α6), f…
View article: Collagen IV of basement membranes: III. Chloride pressure is a primordial innovation that drives and maintains the assembly of scaffolds
Collagen IV of basement membranes: III. Chloride pressure is a primordial innovation that drives and maintains the assembly of scaffolds Open
Collagen IV scaffold is a primordial innovation enabling the assembly of a fundamental architectural unit of epithelial tissues-a basement membrane attached to polarized cells. A family of six α-chains (α1 to α6) coassemble into three dist…
View article: Collagen IVα345 dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer
Collagen IVα345 dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer Open
Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture's disease (GP) and Alport syndrome (AS), and phenocopies of AS…
View article: Sequence-dependent mechanics of collagen reflect its structural and functional organization
Sequence-dependent mechanics of collagen reflect its structural and functional organization Open
Extracellular matrix mechanics influence diverse cellular functions, yet surprisingly little is known about the mechanical properties of their constituent collagen proteins. In particular, network-forming collagen IV, an integral component…
View article: Peroxidasin-mediated bromine enrichment of basement membranes
Peroxidasin-mediated bromine enrichment of basement membranes Open
Significance Bromine is an essential trace element, required for the formation of sulfilimine cross-links in collagen IV, a basement membrane protein. Sulfilimine cross-link formation depends on the production of hypobromous acid by peroxi…
View article: Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Corrigendum
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Corrigendum Open
The article by Casino et al. [ IUCrJ (2018). 5 , 765–779] is corrected.
View article: Molecular Analysis of Goodpasture’s Disease Following Hematopoietic Stem Cell Transplant in a Pediatric Patient, Recalls the Conformeropathy of Wild-Type Anti-GBM Disease
Molecular Analysis of Goodpasture’s Disease Following Hematopoietic Stem Cell Transplant in a Pediatric Patient, Recalls the Conformeropathy of Wild-Type Anti-GBM Disease Open
Background: Goodpasture's disease (GP) is mediated by autoantibodies that bind the glomerular and alveolar basement membrane, causing rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. The autoantibodies bind neoe…
View article: The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus
The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus Open
Significance Statement The receptor discoidin domain receptor 1 (DDR1) is activated by collagen, upregulated in injured kidneys, and contributes to kidney fibrosis, but how DDR1 controls fibrosis is poorly understood. The authors show that…
View article: Two Specific Sulfatide Species Are Dysregulated during Renal Development in a Mouse Model of Alport Syndrome
Two Specific Sulfatide Species Are Dysregulated during Renal Development in a Mouse Model of Alport Syndrome Open
Alport syndrome is caused by mutations in collagen IV that alter the morphology of renal glomerular basement membrane. Mutations result in proteinuria, tubulointerstitial fibrosis, and renal failure but the pathogenic mechanisms are not fu…
View article: A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes
A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes Open
Collagen IV scaffold is a principal component of the basement membrane (BM), a specialized extracellular matrix that is essential for animal multicellularity and tissue evolution. Scaffold assembly begins with the trimerization of α-chains…
View article: Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein
Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein Open
The emergence of the basement membrane (BM), a specialized form of extracellular matrix, was essential in the unicellular transition to multicellularity. However, the mechanism is unknown. Goodpasture antigen-binding protein (GPBP), a BM p…
View article: Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly Open
Basement membranes are extracellular structures of epithelia and endothelia that have collagen IV scaffolds of triple α-chain helical protomers that associate end-to-end, forming networks. The molecular mechanisms by which the noncollageno…
View article: Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes
Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes Open
Background Goodpasture syndrome (GP) is a pulmonary-renal syndrome characterized by autoantibodies directed against the NC1 domains of collagen IV in the glomerular and alveolar basement membranes. Exposure of the cryptic epitope is though…
View article: Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains
Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains Open
Integrins are transmembrane cell-extracellular matrix adhesion receptors that impact many cellular functions. A subgroup of integrins contain an i nserted (I) domain within the α–subunits (αI) that mediate ligand recognition where function…