Barry P. Katz
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View article: Molecular pathogenesis of <i>Haemophilus ducreyi</i> infection in human volunteers
Molecular pathogenesis of <i>Haemophilus ducreyi</i> infection in human volunteers Open
SUMMARY Haemophilus ducreyi is a Gram-negative coccobacillus that forms a distinct lineage with Aggregatibacter pleuropneumoniae and Mannheimia haemolytica within the Pasteurellaceae. H. ducreyi causes chancroid, which is characterized by …
View article: The protein degradation system encoded by <i>hslUV</i> ( <i>ClpYQ</i> ) is dispensable for the virulence of <i>Haemophilus ducreyi</i> in human volunteers
The protein degradation system encoded by <i>hslUV</i> ( <i>ClpYQ</i> ) is dispensable for the virulence of <i>Haemophilus ducreyi</i> in human volunteers Open
Haemophilus ducreyi causes cutaneous ulcers in children who live in yaws-endemic countries and the genital ulcer disease chancroid. In the human host, H. ducreyi resides in an abscess and may need to resist both heat and oxidative stress, …
View article: A <i>Haemophilus ducreyi</i> strain lacking the <i>yfeABCD</i> iron transport system is virulent in human volunteers
A <i>Haemophilus ducreyi</i> strain lacking the <i>yfeABCD</i> iron transport system is virulent in human volunteers Open
Haemophilus ducreyi causes the genital ulcer disease chancroid and painful cutaneous ulcers in children who live in the tropics. To acquire heme from the host, H. ducreyi expresses a TonB-dependent hemoglobin receptor, HgbA, which is neces…
View article: Return to play and risk of repeat concussion in collegiate football players: Comparative analysis from the NCAA Concussion Study (1999-2001) and CARE Consortium (2014-2017)
Return to play and risk of repeat concussion in collegiate football players: Comparative analysis from the NCAA Concussion Study (1999-2001) and CARE Consortium (2014-2017) Open
Objective We compared data from the National Collegiate Athletic Association (NCAA) Concussion Study (1999-2001) and the NCAA-Department of Defense Concussion Assessment, Research and Education (CARE) Consortium (2014-2017) to examine how …
View article: A Randomized Clinical Trial to Assess Caries Arrest by Using Silver Diamine Fluoride in U.S. Children: Interim Findings.
A Randomized Clinical Trial to Assess Caries Arrest by Using Silver Diamine Fluoride in U.S. Children: Interim Findings. Open
Purpose: To assess the effectiveness of 38 percent silver diamine fluoride (SDF) in arresting cavitated caries lesions in young U.S. children. Methods: Children 12 to 71 months of age with severe early childhood caries participated in this…
View article: Formate production is dispensable for <i>Haemophilus ducreyi</i> virulence in human volunteers
Formate production is dispensable for <i>Haemophilus ducreyi</i> virulence in human volunteers Open
Haemophilus ducreyi is a causative agent of cutaneous ulcers in children who live in the tropics and of the genital ulcer disease chancroid in sexually active persons. In the anaerobic environment of abscesses and ulcers, anaerobic respira…
View article: Predicting Dental Caries in Young Children in Primary Health Care Settings
Predicting Dental Caries in Young Children in Primary Health Care Settings Open
Young children need increased access to dental prevention and care. Targeting high caries risk children first helps meet this need. The objective of this study was to develop a parent-completed, easy-to-score, short, accurate caries risk t…
View article: Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries
Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries Open
Dental caries lesions are a clinical manifestation of disease, preceded by microbial dysbiosis, which is poorly characterized and thought to be associated with saccharolytic taxa. Here, we assessed the associations between the oral microbi…
View article: Characteristics and Outcomes of Athletes With Slow Recovery From Sports-Related Concussion
Characteristics and Outcomes of Athletes With Slow Recovery From Sports-Related Concussion Open
This study suggests an overall favorable prognosis for slowly recovering athletes and provides data for athletes and medical teams to consider in calibrating RTP expectations and making decisions about medical disqualification vs ongoing e…
View article: Dispensability of Ascorbic Acid Uptake and Utilization Encoded by <i>ulaABCD</i> for the Virulence of <i>Haemophilus ducreyi</i> in Humans
Dispensability of Ascorbic Acid Uptake and Utilization Encoded by <i>ulaABCD</i> for the Virulence of <i>Haemophilus ducreyi</i> in Humans Open
Compared with wounded skin, ascorbic acid is enriched in pustules of humans experimentally infected with Haemophilus ducreyi. Compared with the broth-grown inocula, transcription of the H. ducreyi ulaABCD operon, which encodes genes for as…
View article: Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome
Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome Open
The hematopoietic system is highly sensitive to stress from both aging and radiation exposure, and the hematopoietic acute radiation syndrome (H-ARS) should be modeled in the geriatric context separately from young for development of age-a…
View article: CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection
CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection Open
The increasing prevalence of urinary tract infections (UTIs) due to antibiotic-resistant uropathogenic Escherichia coli (UPEC) is a major public health concern. Bacteria contain proteins that sense their environment and have no human homol…
View article: Tooth Eruption and Early Childhood Caries: A Multisite Longitudinal Study.
Tooth Eruption and Early Childhood Caries: A Multisite Longitudinal Study. Open
Purpose: The purpose of this study was to assess the relationship between the number of teeth present at 12 months and decayed, missing, or filled surfaces (dmfs) at 30 and 48 months. Methods: Data are from a longitudinal, multisite study …
View article: Corrigendum to: Human Challenge Studies Are Unlikely to Accelerate Coronavirus Vaccine Licensure due to Ethical and Practical Issues
Corrigendum to: Human Challenge Studies Are Unlikely to Accelerate Coronavirus Vaccine Licensure due to Ethical and Practical Issues Open
This corrects the article "Human Challenge Studies Are Unlikely to Accelerate Coronavirus Vaccine Licensure Due to Ethical and Practical Issues" in volume 222 on page 1572; https://doi.org/10.1093/infdis/jiaa457
View article: Assessment of Blood Biomarker Profile After Acute Concussion During Combative Training Among US Military Cadets
Assessment of Blood Biomarker Profile After Acute Concussion During Combative Training Among US Military Cadets Open
This study's findings indicate that blood biomarkers have potential for use as research tools to better understand the pathobiological changes associated with concussion and to assist with injury identification and recovery from combative …
View article: Effects of Rare Microbiome Taxa Filtering on Statistical Analysis
Effects of Rare Microbiome Taxa Filtering on Statistical Analysis Open
Background: The accuracy of microbial community detection in 16S rRNA marker-gene and metagenomic studies suffers from contamination and sequencing errors that lead to either falsely identifying microbial taxa that were not in the sample o…
View article: Streptococcus pyogenes Is Associated with Idiopathic Cutaneous Ulcers in Children on a Yaws-Endemic Island
Streptococcus pyogenes Is Associated with Idiopathic Cutaneous Ulcers in Children on a Yaws-Endemic Island Open
Cutaneous ulcers (CU) affect approximately 100,000 children in the tropics each year. While two-thirds of CU are caused by Treponema pallidum subspecies pertenue and Haemophilus ducreyi , the cause(s) of the remaining one-third is unknown.
View article: Development of a Model of the Acute and Delayed Effects of High Dose Radiation Exposure in Jackson Diversity Outbred Mice; Comparison to Inbred C57BL/6 Mice
Development of a Model of the Acute and Delayed Effects of High Dose Radiation Exposure in Jackson Diversity Outbred Mice; Comparison to Inbred C57BL/6 Mice Open
Development of medical countermeasures against radiation relies on robust animal models for efficacy testing. Mouse models have advantages over larger species due to economics, ease of conducting aging studies, existence of historical data…
View article: Effects of microbiome rare taxa filtering on statistical analysis
Effects of microbiome rare taxa filtering on statistical analysis Open
Background: Accuracy of microbial community detection in 16S rRNA marker-gene and metagenomic studies suffers from contamination and sequencing errors that lead to either falsely identifying microbial taxa that were not in the sample or mi…
View article: Improving Caries Risk Prediction Modeling: A Call for Action
Improving Caries Risk Prediction Modeling: A Call for Action Open
Dentistry has entered an era of personalized/precision care in which targeting care to groups, individuals, or even tooth surfaces based on their caries risk has become a reality to address the skewed distribution of the disease. The best …
View article: Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis
Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis Open
Only a minority of heavy drinking individuals develop alcoholic hepatitis (AH), for unclear reasons. We analyzed data from the Translational Research and Evolving Alcoholic Hepatitis Treatment cohort: subjects who drink heavily with normal…
View article: Association of Blood Biomarkers With Acute Sport-Related Concussion in Collegiate Athletes
Association of Blood Biomarkers With Acute Sport-Related Concussion in Collegiate Athletes Open
The results suggest that blood biomarkers can be used as research tools to inform the underlying pathophysiological mechanism of concussion and provide additional support for future studies to optimize and validate biomarkers for potential…
View article: Maturation of the Oral Microbiome in Caries-Free Toddlers: A Longitudinal Study
Maturation of the Oral Microbiome in Caries-Free Toddlers: A Longitudinal Study Open
Understanding the development of the oral microbiota in healthy children is of great importance to oral and general health. However, limited data exist on a healthy maturation of the oral microbial ecosystem in children. Moreover, the data…
View article: Aetiology and prevalence of mixed-infections and mono-infections in non-gonococcal urethritis in men: a case-control study
Aetiology and prevalence of mixed-infections and mono-infections in non-gonococcal urethritis in men: a case-control study Open
Objectives Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) cause the majority of non-gonococcal urethritis (NGU). The role of Ureaplasma urealyticum (UU) in NGU is unclear. Prior case–control studies that examined the association…
View article: Return to play and risk of repeat concussion in collegiate football players: comparative analysis from the NCAA Concussion Study (1999–2001) and CARE Consortium (2014–2017)
Return to play and risk of repeat concussion in collegiate football players: comparative analysis from the NCAA Concussion Study (1999–2001) and CARE Consortium (2014–2017) Open
Objective We compared data from the National Collegiate Athletic Association (NCAA) Concussion Study (1999–2001) and the NCAA-Department of Defense Concussion Assessment, Research and Education (CARE) Consortium (2014–2017) to examine how …
View article: A Class I <i>Haemophilus ducreyi</i> Strain Containing a Class II <i>hgbA</i> Allele Is Partially Attenuated in Humans: Implications for HgbA Vaccine Efficacy Trials
A Class I <i>Haemophilus ducreyi</i> Strain Containing a Class II <i>hgbA</i> Allele Is Partially Attenuated in Humans: Implications for HgbA Vaccine Efficacy Trials Open
Haemophilus ducreyi causes chancroid and is a major cause of cutaneous ulcers in children. Due to environmental reservoirs, both class I and class II H. ducreyi strains persist in cutaneous ulcer regions of endemicity following mass drug a…
View article: Wearable Smart Glasses for Assessment of Eye-Contact Behavior in Children With Autism
Wearable Smart Glasses for Assessment of Eye-Contact Behavior in Children With Autism Open
To promote eye contact learning and behavior in children with autism, there exist specialized environments as well as smartphone applications. However, few currently available techniques support the assessment of desired behavioral improve…
View article: Detection of Rectal Chlamydia trachomatis in Heterosexual Men Who Report Cunnilingus
Detection of Rectal Chlamydia trachomatis in Heterosexual Men Who Report Cunnilingus Open
Background Rectal infection with Chlamydia trachomatis (CT) is frequent in women who deny receptive anal sex and is thought to arise from autoinoculation of the rectum from vaginal secretions. An alternate hypothesis is that oral sex inocu…
View article: Predicting Caries in Medical Settings: Risk Factors in Diverse Infant Groups
Predicting Caries in Medical Settings: Risk Factors in Diverse Infant Groups Open
Expanded partnership with the medical community is a promising strategy for reducing disparities in dental caries among young children. However, no validated caries risk instrument exists for use in primary health care settings. To help re…