Bengt Kayser
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View article: AltitudeOmics: Breathing variability at rest and during exercise across 16 days of acclimatization to hypobaric hypoxia
AltitudeOmics: Breathing variability at rest and during exercise across 16 days of acclimatization to hypobaric hypoxia Open
Ventilatory acclimatization to high altitude is an important adaption to prolonged time at altitude. Changes in breathing variability over a 16 day acclimatization period to altitude, when awake, were quantified. We tested the hypothesis t…
View article: The role of acid‐base balance in cerebrovascular and ventilatory responses to CO<sub>2</sub> during 10 h normobaric hypoxia
The role of acid‐base balance in cerebrovascular and ventilatory responses to CO<sub>2</sub> during 10 h normobaric hypoxia Open
Hyperventilation‐induced alterations in acid‐base buffering play a crucial role in resetting the cerebrovascular and ventilatory control during high‐altitude acclimatisation. This study examines the relationship between cerebrovascular CO …
View article: Parental modelling has a sustainable effect on offspring’s physical activity: the SOPHYA cohort
Parental modelling has a sustainable effect on offspring’s physical activity: the SOPHYA cohort Open
Parental role modelling influences children's PA behavior in a sustainable and sex-specific manner from childhood to young adulthood. PA interventions for parents have the potential for transgenerational benefits.
View article: Downregulation of the mitochondrial tRNA-derived fragment mt-tRF-Leu<sup>TAA</sup> enhances skeletal muscle insulin sensitivity
Downregulation of the mitochondrial tRNA-derived fragment mt-tRF-Leu<sup>TAA</sup> enhances skeletal muscle insulin sensitivity Open
Fasting downregulates levels of mt-tRF-Leu TAA in skeletal muscle. While this small RNA fragment is enriched in the mitochondria of myotubes, inhibition of mt-tRF-Leu TAA in myotubes enhances insulin-mediated glucose uptake. Consistently, …
View article: Lack of Altitude Medicine Knowledge Among Mountaineers in the Italian Alps
Lack of Altitude Medicine Knowledge Among Mountaineers in the Italian Alps Open
Berendsen, Remco R., Dirk C.A.A. de Vries, Alea Steger, Nadine Herold, Feico J.J. Halbertsma, Adriaan F. Norbart, Hannes Gatterer, and Bengt Kayser. Lack of altitude medicine knowledge among mountaineers in the Italian Alps. High Alt Med B…
View article: A data-driven model to estimate breathing-induced intra-trunk blood shifts during exercise
A data-driven model to estimate breathing-induced intra-trunk blood shifts during exercise Open
This study presents an electrical model of the cardiovascular system, capable of estimating breath-by-breath intra-trunk blood shifting (Vbs IT ) between the abdomen and thorax. The model was validated using data from healthy participants …
View article: Cluster-Specific Urban Contexts Associated with High Levels of Sleep Impairment and Daytime Sleepiness: Findings from the Urbasan Collaborative Study
Cluster-Specific Urban Contexts Associated with High Levels of Sleep Impairment and Daytime Sleepiness: Findings from the Urbasan Collaborative Study Open
Introduction Impaired sleep is a global health concern. However, the environmental factors contributing to sleep impairment in urban settings are still not well understood. Methodology This study involved 179 participants from a Swiss muni…
View article: Participation in organised sports and longitudinal development of physical activity in Swiss youth: the population-based SOPHYA cohort
Participation in organised sports and longitudinal development of physical activity in Swiss youth: the population-based SOPHYA cohort Open
BACKGROUND: Maintaining physical activity throughout life is crucial for overall health and wellbeing. Yet the age-related decline in average physical activity, a natural phenomenon also observed in animals, poses a challenge. This study a…
View article: S10-4: Facilitating new interdisciplinary collaborations for active mobility: The Academic Observatory for Cycling and Active Mobilities (OUVEMA)
S10-4: Facilitating new interdisciplinary collaborations for active mobility: The Academic Observatory for Cycling and Active Mobilities (OUVEMA) Open
Purpose Although the current social, environmental, and health-related challenges call for a reflection of the place of mobility in tomorrow’s world, modern societies continue to be shaped by decades of motorization. Most European countrie…
View article: Weekend physical activity profiles and their relationship with quality of life: The SOPHYA cohort of Swiss children and adolescents
Weekend physical activity profiles and their relationship with quality of life: The SOPHYA cohort of Swiss children and adolescents Open
Introduction Quality of life (QoL) is an important health indicator among children and adolescents. Evidence on the effect of physical activity (PA)-related behaviors on QoL among youth remains inconsistent. Conventional accelerometer-deri…
View article: Repeated sprint training in hypoxia induces specific skeletal muscle adaptations through <scp>S100A</scp> protein signaling
Repeated sprint training in hypoxia induces specific skeletal muscle adaptations through <span>S100A</span> protein signaling Open
Athletes increasingly engage in repeated sprint training consisting in repeated short all‐out efforts interspersed by short recoveries. When performed in hypoxia (RSH), it may lead to greater training effects than in normoxia (RSN); howeve…
View article: Could the North American opioid crisis hit Switzerland?
Could the North American opioid crisis hit Switzerland? Open
No abstract available.
View article: Cross-Sectional but Not Prospective Association of Accelerometry-Derived Physical Activity With Quality of Life in Children and Adolescents
Cross-Sectional but Not Prospective Association of Accelerometry-Derived Physical Activity With Quality of Life in Children and Adolescents Open
Objectives: This study aims to quantify the cross-sectional and prospective associations between quality of life (QoL) and moderate-to-vigorous physical activity (MVPA). Methods: This study was based on the Swiss children’s Objectively mea…
View article: Are there specific molecular adaptations of skeletal muscle to repeated sprint training in hypoxia?
Are there specific molecular adaptations of skeletal muscle to repeated sprint training in hypoxia? Open
Introduction
Athletes increasingly engage in repeated sprint training that consists of repeated short all-out effort (< 10 s) interspersed by short recoveries (< 60 s). When performed in hypoxia (repeated sprints in hypoxia, RSH), it may …
View article: Sound pressure radiated by a point-source in arbitrary motion above an absorbing ground: Application to aircraft noise
Sound pressure radiated by a point-source in arbitrary motion above an absorbing ground: Application to aircraft noise Open
The acoustic regulations are increasingly stringent for aircraft noise.Aircraft manufacturers must therefore be able to predict accurately aircraft noise for certification scenarios as early as the design phase.Acoustic propagation models …
View article: Effect of an exercise program, in addition to diet, to avoid insulin prescription in women with gestational diabetes: a randomized controlled trial
Effect of an exercise program, in addition to diet, to avoid insulin prescription in women with gestational diabetes: a randomized controlled trial Open
Objective: To evaluate the efficacy of an exercise intervention, in addition to usual care, to prevent or delay insulin prescription in women with gestational diabetes mellitus (GDM). Design: Randomised controlled trial Setting : Universit…
View article: Ryanodine receptor type 1 content decrease‐induced endoplasmic reticulum stress is a hallmark of myopathies
Ryanodine receptor type 1 content decrease‐induced endoplasmic reticulum stress is a hallmark of myopathies Open
Background Decreased ryanodine receptor type 1 (RyR1) protein levels are a well‐described feature of recessive RYR1 ‐related myopathies. The aim of the present study was twofold: (1) to determine whether RyR1 content is also decreased in o…
View article: Where sports performance meets reproductive rights: hormonal contraception
Where sports performance meets reproductive rights: hormonal contraception Open
Rational To discuss the use of hormonal contraception (HC) in elite women's competitive sports from an anti-doping perspective because 1) it changes the natural female hormonal milieu; 2) is used to manipulate the menstrual cycle with perf…
View article: AltitudeOmics: effects of 16 days acclimatization to hypobaric hypoxia on muscle oxygen extraction during incremental exercise
AltitudeOmics: effects of 16 days acclimatization to hypobaric hypoxia on muscle oxygen extraction during incremental exercise Open
During incremental exercise muscle deoxyhemoglobin (HHb) and oxygen consumption (V̇o 2 ) both increase linearly, and the slope of their relationship is an indirect index of local muscle O 2 extraction. The latter was assessed at sea level, …
View article: Acute effects of neuromuscular electrical stimulation on contralateral plantar flexor neuromuscular function
Acute effects of neuromuscular electrical stimulation on contralateral plantar flexor neuromuscular function Open
Introduction
Neuromuscular electrical stimulation (NMES) is used in athletes to enhance muscle strength (Filipovic et al., 2012) or in patients to restore muscle strength (Nussbaum et al., 2017). The increased maximal voluntary contractio…
View article: RyR1 protein content is reduced in inflammatory and mitochondrial myopathies and induces ER stress
RyR1 protein content is reduced in inflammatory and mitochondrial myopathies and induces ER stress Open
Decreased ryanodine receptor type 1 (RyR1) protein is a hallmark of recessive RYR1 -related myopathies ( RyR1 -RM), which are caused by recessive mutations in the RYR1 gene. It is not clear how the decrease in the RyR1 protein triggers mus…
View article: Steps parameters of elderly patients hospitalised for an acute medical illness in a Swiss University Hospital: an observational pilot study
Steps parameters of elderly patients hospitalised for an acute medical illness in a Swiss University Hospital: an observational pilot study Open
BACKGROUND: Objective mobility goals for elderly hospitalised medical patients remain debated. We therefore studied steps parameters of elderly patients hospitalised for an acute illness, to determine goals for future interventional trials…
View article: Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms
Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms Open
Baroreflex sensitivity (BRS) is a measure of cardiovagal baroreflex and is lower in normobaric and hypobaric hypoxia compared to normobaric normoxia. The aim of this study was to assess the effects of hypobaria on BRS in normoxia and hypox…