Martin B. Leon
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View article: Tricuspid valve replacement outcomes by baseline tricuspid regurgitation severity: the TRISCEND II trial
Tricuspid valve replacement outcomes by baseline tricuspid regurgitation severity: the TRISCEND II trial Open
Background and Aims The TRISCEND II trial demonstrated superior clinical benefits for patients with ≥severe tricuspid regurgitation (TR) treated with the EVOQUE transcatheter tricuspid valve replacement (TTVR) system plus medical therapy v…
View article: The low-risk TAVR trials—A critical appraisal of the current landscape
The low-risk TAVR trials—A critical appraisal of the current landscape Open
The low-risk TAVR vs SAVR RCTs - PARTNER-3, Evolut Low-Risk, DEDICATE, and NOTION-2 - demonstrate that TAVR is at least as effective as SAVR in terms of early mortality and disabling stroke, although outcomes varied across studies. The exc…
View article: Detecting structural heart disease from electrocardiograms using AI
Detecting structural heart disease from electrocardiograms using AI Open
Early detection of structural heart disease is critical to improving outcomes, but widespread screening remains limited by the cost and accessibility of imaging tools such as echocardiography1,2. Recent advances in machine learning applied…
View article: Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial
Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial Open
BACKGROUND: The EARLY TAVR trial (Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis) demonstrated that early transcatheter aortic valve replacement (TAVR) intervention was superior to clinica…
View article: Deep learning for echocardiographic assessment and risk stratification of aortic, mitral, and tricuspid regurgitation: the DELINEATE-regurgitation study
Deep learning for echocardiographic assessment and risk stratification of aortic, mitral, and tricuspid regurgitation: the DELINEATE-regurgitation study Open
Background and Aims Classification and risk stratification in aortic (AR), mitral (MR), and tricuspid regurgitation (TR) remains a significant clinical challenge. This study aimed to develop an artificial intelligence (AI) system to assess…
View article: Low Contrast Strategies in TAVR: Feasibility and Outcomes to Prevent Renal Injury in Chronic Kidney Disease
Low Contrast Strategies in TAVR: Feasibility and Outcomes to Prevent Renal Injury in Chronic Kidney Disease Open
Background Contrast volume is a major risk factor for acute kidney injury (AKI) in patients with chronic kidney disease (CKD) after TAVR. Use of a low‐contrast (LC) protocol in TAVR may reduce AKI without impacting other clinical outcomes.…
View article: The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting
The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting Open
Aims This study aims to assess the changes in cardiac damage stage in a real-world cohort of patients undergoing transcatheter aortic valve implantation (TAVI), and to investigate the prognostic value of cardiac damage stage evolution. Met…
View article: Late Clinical Outcomes of Balloon-Expandable Valves in Small Annuli
Late Clinical Outcomes of Balloon-Expandable Valves in Small Annuli Open
Five-year clinical outcomes were excellent and comparable between patients with small vs large aortic annuli. Outcomes in patients with small annuli were not affected by 30-day MG or PPM.
View article: Aortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis
Aortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis Open
In this meta-analysis of 4 RCTs, early AVR was associated with a significant reduction in unplanned cardiovascular or HF hospitalization and stroke and no differences in all-cause and cardiovascular mortality compared with CS.
View article: Clinical Outcomes According to Aortic Stenosis Management: Insights From Real‐World Practice
Clinical Outcomes According to Aortic Stenosis Management: Insights From Real‐World Practice Open
Background Real‐world data regarding clinical outcomes according to aortic stenosis (AS) management are scarce. Therefore, we aimed to investigate long‐term management across the spectrum of outpatients with AS. Methods and Results Between…
View article: Outcomes of Balloon-Expandable Transcatheter Aortic Valve Replacement in Younger Patients in the Low-Risk Era
Outcomes of Balloon-Expandable Transcatheter Aortic Valve Replacement in Younger Patients in the Low-Risk Era Open
Importance Guidelines advise heart team assessment for all patients with aortic stenosis, with surgical aortic valve replacement recommended for patients younger than 65 years or with a life expectancy greater than 20 years. If bioprosthet…
View article: Cerebral Embolic Protection by Geographic Region
Cerebral Embolic Protection by Geographic Region Open
Importance Transcatheter aortic valve replacement (TAVR) is an established treatment option for many patients with severe symptomatic aortic stenosis; however, debris dislodged during the procedure can cause embolic stroke. The Sentinel ce…
View article: Mitral regurgitation evolution after transcatheter tricuspid valve interventions—a sub-analysis of the TriValve registry
Mitral regurgitation evolution after transcatheter tricuspid valve interventions—a sub-analysis of the TriValve registry Open
Aims Transcatheter tricuspid valve interventions (TTVI) are increasingly used to treat patients with significant tricuspid regurgitation (TR). The evolution of concurrent mitral regurgitation (MR) severity after TTVI is currently unknown a…
View article: Early Aortic Valve Replacement in Moderate Aortic Stenosis
Early Aortic Valve Replacement in Moderate Aortic Stenosis Open
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