Abstract Assembling natural proteins into large, strong, bone‐mimetic scaffolds for repairing bone defects in large‐animal load‐bearing sites remain elusive. Here this challenge is tackled by assembling pure silk fibroin (SF) into 3D scaffolds with cortical‐bone‐like lamellae, superior strength, and biodegradability through freeze‐casting. The unique lamellae promote the attachment, migration, and proliferation of tissue‐regenerative cells (e.g., mesenchymal stem cells [MSCs] and human umbilical vein endothelial c…

Abstract Uncontrolled deep bleeding, commonly encountered in surgical procedures, combat injuries, and trauma, poses a significant threat to patient survival and recovery. The development of effective hemostatic agents capable of precisely targeting trauma sites in deep tissues and rapidly halt bleeding remains a considerable challenge. Drawing inspiration from the natural hemostatic cascade, we present platelet-like microspheres composed of silk fibroin (SF) and thrombus-targeting peptides, engineered to mimic na…

Abstract Extracellular vesicles (EVs) secreted by stem cells have become a promising cell‐free approach in regenerative medicine, with significant potential for the repair and treatment of musculoskeletal tissues and disorders. However, the limited bioactivity and scalability of EV production pose significant challenges for commercial production and clinical translation. To overcome these challenges, researchers have started exploring how the cellular microenvironment can modulate EV characteristics and enhance th…

Onychomycosis is a prevalent nail infection caused by fungi, presenting significant treatment challenges due to poor drug penetration and high recurrence rates. Current treatments, including oral and topical antifungals, often have limited efficacy and can lead to resistance. Transfersomes are lipid vesicles that can penetrate skin for transdermal drug delivery. Here, a transfersome (termed THT) capable of penetrating nails to deliver a photosensitizer (hematoporphyrin monomethyl ether, HMME) and an antifungal che…

This study explores the application of children’s picture books in community education, focusing on their role in enhancing cognitive abilities, promoting emotional development, and strengthening family education. Through a combination of theoretical analysis and multiple case studies, the research examines the multifaceted educational value of picture books. Findings reveal that picture books, with their vivid illustrations and engaging narratives, transcend traditional educational functions by fostering parent-c…