Explanipedia

Charge symmetry breaking in neutral polyzwitterions Open

Yeseul Lee, M. Muthukumar · 2025

Universal law of hierarchical dynamics in gels arising from confluence of local physically dynamic bonds Open

Yi Zhao, Yu Jie, Yuan Xue, Zhiwei Shi, Yuanchen Dong , et al. · 2025

Gels comprised of dynamic bonds are important candidates for the emerging 'intelligent' gels due to their unique characteristics. We report a universal law of hierarchical gel dynamics arising from association-dissociation of physical cros…

Beyond Alpha: A Comparative Study of Mutual Fund Performance Across Market Cycles Open

M. Muthukumar · 2025

Beyond monopole electrostatics in regulating conformations of intrinsically disordered proteins Open

Michael Phillips, M. Muthukumar, Kingshuk Ghosh · 2024

Conformations and dynamics of an intrinsically disordered protein (IDP) depend on its composition of charged and uncharged amino acids, and their specific placement in the protein sequence. In general, the charge (positive or negative) on …

Dipole Theory of Polyzwitterion Microgels and Gels Open

M. Muthukumar · 2024

The behavior of polyzwitterions, constituted by dipole-like zwitterionic monomers, is significantly different from that of uniformly charged polyelectrolytes. The origin of this difference lies in the intrinsic capacity of polyzwitterions …

Active dynamics of charged macromolecules. Open

Tapas Singha, Siao-Fong Li, M. Muthukumar · 2024

We study the role of active coupling on the transport properties of homogeneously charged macromolecules in an infinitely dilute solution. An enzyme becomes actively bound to a segment of the macromolecule, exerting an electrostatic force …

3D Printing of Aqueous Two‐Phase Systems with Linear and Bottlebrush Polyelectrolytes Open

Zichen Jin, Honggyu Seong, Satyam Srivastava, Alex McGlasson, Todd Emrick , et al. · 2024

We formed core–shell‐like polyelectrolyte complexes (PECs) from an anionic bottlebrush polymer with poly (acrylic acid) side chains with a cationic linear poly (allylamine hydrochloride). By varying the pH, the number of side chains of the…

Pivotal Roles of Triple Screening-Topological, Electrostatic, and Hydrodynamic-On Dynamics in Semidilute Polyelectrolyte Solutions Open

Rajeev Kumar, Ali H. Slim, Antonio Faraone, Jan‐Michael Y. Carrillo, Ryan Poling‐Skutvik , et al. · 2024

For semidilute polyelectrolyte solutions, it is generally assumed that topological, electrostatic, and hydrodynamic interactions are screened (called triple screening). Despite a large body of research focused on polyelectrolyte solutions,…

Retrospective herbal accession on liver cirrhosis: current insights and future prospects Open

R Thaila, J Jayalakshmi, Rajeev Thekke Puthalath, M. Muthukumar, Danyalakshmi PGS , et al. · 2023

Chronic liver disease encompasses a spectrum of liver conditions spanning fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Despite advancements in conventional medicine, growing emphasis is placed on phytomedicine…

Memory formation Open

Sidney R. Nagel, Srikanth Sastry, Zorana Zeravcic, M. Muthukumar · 2023

Dipole-driven interlude of mesomorphism in polyelectrolyte solutions Open

Di Jia, M. Muthukumar · 2022

Uniformly charged polyelectrolyte molecules disperse uniformly in aqueous electrolyte solutions, due to electrostatic repulsion between them. In stark contrast to this well-established result of homogeneous polyelectrolyte solutions, we re…

Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms Open

Khatcher O. Margossian, Marcel U. Brown, Todd Emrick, M. Muthukumar · 2022

Traditionally, complex coacervation is regarded as a process whereby two oppositely charged polyelectrolytes self-assemble into spherical droplets. Here, we introduce the polyzwitterionic complex, “pZC”, formed by the liquid-liquid phase s…

Topologically frustrated dynamics in an uncharged Tetra-PEG gel Open

Di Jia, Yui Tsuji, Mitsuhiro Shibayama, M. Muthukumar · 2022

Based on our previous discovery of non-diffusive topologically frustrated dynamics in a charged system where electrostatic interactions between the charged guest and the charged host gel play a role ( Nature Communications , 2018, 9, 2248;…

Issue Information ‐ TOC Open

Ying Jia, Maria Monte, Conor Doss, Rufina G. Alamo, René Androsch , et al. · 2021

Research data supporting "Dynamics of driven polymer transport through a nanopore" Open

Kaikai Chen, Ining A. Jou, Niklas Ermann, M. Muthukumar, Ulrich F. Keyser , et al. · 2021

This research data supports “Dynamics of driven polymer transport through a nanopore” which is published in “Nature Physics”.\nThe data set contains the data for each figure in the paper in the corresponding folder (Figure 1 – Figure 5). I…

Theory of Ionic Conductivity with Morphological Control in Polymers Open

M. Muthukumar · 2021

We present a general theory of ionic conductivity in polymeric materials consisting of percolated ionic pathways. Identifying two key length scales corresponding to inter-path permeation distance ξ and one-dimensional hopping conduc…

Entropic barrier of topologically immobilized DNA in hydrogels Open

Kuo Chen, M. Muthukumar · 2021

Significance Movement of charged macromolecules in crowded aqueous environments is ubiquitous in nature. The omnipresent capacity of macromolecules to adopt differing numbers of conformations in response to local spatiotemporal environment…

Dynamics of driven polymer transport through a nanopore Open

Kaikai Chen, Ining A. Jou, Niklas Ermann, M. Muthukumar, Ulrich F. Keyser , et al. · 2021

Nucleotide Dynamics During Flossing of Polycation-DNA-Polycation through a Nanopore using Molecular Dynamics Open

Jyoti P. Mahalik, M. Muthukumar · 2021

The full potential of solid state nanopores is yet to be realized for genome sequencing. Due to its robustness it can handle strong voltage amplitude and frequency. The effect of strong alternating voltage on the dynamics of nucleotides du…

Coupled dynamics of charged macromolecules and counterions mediated by binding enzymes Open

Tapas Singha, Siao-Fong Li, M. Muthukumar · 2021

We investigate the role of active coupling on the transport properties of the macromolecules. The active coupling comes due to bound enzymes with a segment of the macromolecule wherein the enzyme exerts an electrostatic force on the segmen…

Langevin dynamics simulation of protein dynamics in nanopores at microsecond timescales Open

Jyoti P. Mahalik, Jeffrey Cifello, M. Muthukumar · 2021

With rapid advancement in the fields of nanopore analysis of protein, it has become imperative to develop modeling framework for understanding the protein dynamics in nanopores. Such modeling framework should include the effects of electro…

Theory of Charged Gels: Swelling, Elasticity, and Dynamics Open

Di Jia, M. Muthukumar · 2021

The fundamental attributes of charged hydrogels containing predominantly water and controllable amounts of low molar mass electrolytes are of tremendous significance in biological context and applications in healthcare. However, a rigorous…

Voltage-Driven Polyelectrolyte Complexation Inside a Nanopore Open

Prabhat Tripathi, Byoung-jin Jeon, M. Muthukumar · 2021

This thesis investigates how a pair of oppositely charged macromolecules can be driven by an electric field to form a polyelectrolyte complex inside a nanopore. To observe and isolate an individual complex pair, a model protein nanopore, e…

Bayesian analysis of Nanopore Detector Array signals. Open

Habib N. Najm, Bert Debusschere, M. Muthukumar, José M. Ortega, Murphy Ryan · 2020

Issue Information ‐ Cover Description Open

Daniel Heinz, Annette Meister, Hazrat Hussain, Karsten Busse, Jörg Kreßler , et al. · 2020

The center of the image represents the hydrogels presented by Michael Malkoch and colleagues for their article on page 3153.The hydrogel network is depicted on a macromolecular scale in the top left.The bottom right shows how cells (human …

Issue Information ‐ Cover Description Open

Sanjay Kshitij, Philipp Shinde, Michael Michael, Ying Jia, Tae‐Lim Choi , et al. · 2020

Theoretical and experimental scientists collaborate in the study of (A1-D)-(A2-D) type random copolymers for organic photovoltaics.In the article on page 2792, Ali Cirpan and colleagues investigate the effectiveness of single-atom replacem…

Issue Information‐TOC Open

Ying Jia, Maria Monte, Conor Doss, Rufina G. Alamo, René Androsch , et al. · 2020

An optical microscope image of the poly(ethylene oxide) precursor material (PEO-4000) and of the corresponding film are shown in the lower and upper reaches of the image, respectively.By using the green light of a femtosecond laser system,…

Issue Information ‐ Cover Description Open

Maxwell W. Terban, Alexander M. Pütz, Gökçen Savaşçı, Ying Jia, Tae‐Lim Choi , et al. · 2020

Ratcheting behavior of crosslinked epoxy polymers was investigated by Maenghyo Cho and his team on page 1617, considering the effects of different molecular structures of curing agents (aromatic and aliphatic) by atomistic simulations.Vari…

Surface Tension of Dielectric–Air Interfaces Open

Rajeev Kumar, M. Muthukumar · 2020

Analytical and semianalytical expressions for the surface tension of dielectric-air interfaces are presented after considering local and nonlocal dielectric effects near interfaces. It is shown that the nonlocal effects of dielectrics are …

Issue Information ‐ Cover Description Open

Takashi Doi, Yuji Yada, Kota Nishino, Makoto Sugiura, Tsutomu Shimokawa , et al. · 2020

INTRAMOLECULAR H-BONDING, POLYMIDEIn the work reported on page 969, Chunhai Chen and colleagues prepared new poly (benzimidazole imide)s with intramolecular hydrogen bonds.The H-bonding "locks" the H atom in the N-H group of benzimidazole …

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