Narayan Prasad
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View article: Exploring the Prognostic Significance of <scp><i>IL10</i></scp> Variants and Their Mechanistic Regulation in Diabetic Nephropathy
Exploring the Prognostic Significance of <span><i>IL10</i></span> Variants and Their Mechanistic Regulation in Diabetic Nephropathy Open
IL10 is a very effective anti‐inflammatory cytokine. IL10 imbalance is linked to type 2 diabetes mellitus (T2DM) and also to renal hypertrophy, glomerular membrane thickening, and onset of diabetic nephropathy (DN). We aimed to investigate…
View article: Oral Microbiota Dysbiosis in Firefighters and the Potential Contributing Environmental and Lifestyle Factors Based on a Case-Control Study
Oral Microbiota Dysbiosis in Firefighters and the Potential Contributing Environmental and Lifestyle Factors Based on a Case-Control Study Open
Epidemiological studies show firefighters have increased risks of cancer, diabetes, and cardiovascular disease. To explore links between occupational/environmental exposures and dysbiosis-associated health risks, this case-control study co…
View article: Randomized Double-Blind Placebo-Controlled Trial of Desmopressin for Post–Kidney Biopsy Bleeding
Randomized Double-Blind Placebo-Controlled Trial of Desmopressin for Post–Kidney Biopsy Bleeding Open
Desmopressin effectively reduces postbiopsy bleeding and hematoma formation with manageable side effects, supporting its role as a prophylactic option in kidney biopsies. Further studies are needed to confirm its broader clinical applicati…
View article: T-helper Type 17 and Regulatory T-cell Profiles in Renal Allograft Recipients with Calcineurin Inhibitor Toxicity
T-helper Type 17 and Regulatory T-cell Profiles in Renal Allograft Recipients with Calcineurin Inhibitor Toxicity Open
Introduction: The immune profiles of Th17 and Treg cells have been not studied in-depth in renal transplant recipients (RTRs) with calcineurin inhibitor toxicity (CNIT) till now. Therefore, we aimed to determine the Th17 and Treg cell prof…
View article: Cloud Computing and Data Security Challenges: A Nepal Case
Cloud Computing and Data Security Challenges: A Nepal Case Open
When it comes to storing and accessing data, cloud computing provides an alternative option for users of computers and mobile devices. Nepal has a lot of problems with cloud computing and protecting data. Data security in the cloud and clo…
View article: Nephrology’s Next Frontier: Expanding the Reach of CAR T-Cell Therapy for Refractory Lupus Nephritis and Beyond
Nephrology’s Next Frontier: Expanding the Reach of CAR T-Cell Therapy for Refractory Lupus Nephritis and Beyond Open
Chimeric antigen receptor (CAR) T-cell therapy has recently evolved beyond cancer therapy’s boundary to treating autoimmune diseases such as lupus nephritis. In CAR T-cell therapy, the genetically engineered patient’s T cells express a rec…
View article: Nephrology Services in Uttar Pradesh
Nephrology Services in Uttar Pradesh Open
Uttar Pradesh comprises 16.5% of India’s population and is the most populated state of the country. Compared to the central government budget of 2.1% of GDP on health care, the state has promised an expenditure of 7.2% on health care. The …
View article: Association of Donor Vascular Endothelial Growth Factor Gene Polymorphism With Acute Renal Allograft Rejection
Association of Donor Vascular Endothelial Growth Factor Gene Polymorphism With Acute Renal Allograft Rejection Open
Background Recipient's VEGF‐A polymorphisms have been reported to be associated with the risk of acute allograft rejection. However, an association of the donor's VEGF‐A gene polymorphism with rejection remained unelucidated till now. Meth…
View article: Carbon Nanotube Immunotoxicity in Alveolar Epithelial Type II Cells Is Mediated by Physical Contact-Independent Cell–Cell Interaction with Macrophages as Demonstrated in an Optimized Air–Liquid Interface (ALI) Coculture Model
Carbon Nanotube Immunotoxicity in Alveolar Epithelial Type II Cells Is Mediated by Physical Contact-Independent Cell–Cell Interaction with Macrophages as Demonstrated in an Optimized Air–Liquid Interface (ALI) Coculture Model Open
There is a need for the assessment of respiratory hazard potential and mode of action of carbon nanotubes (CNTs) before their approval for technological or medical applications. In CNT-exposed lungs, both alveolar macrophages (MФs), which …
View article: Novel mutation patterns in children with steroid-resistant nephrotic syndrome
Novel mutation patterns in children with steroid-resistant nephrotic syndrome Open
Background Idiopathic nephrotic syndrome (NS) in children poses treatment challenges, with a subset developing steroid-resistant nephrotic syndrome (SRNS). Genetic factors play a role, yet data on paediatric SRNS genetics in India are scar…
View article: Chronic Heat Exposure Modulates Innate and Adaptive Immune Responses in Firefighters
Chronic Heat Exposure Modulates Innate and Adaptive Immune Responses in Firefighters Open
Global fire activities, which are getting worse due to climate change, cause both environmental and human health hazards. Firefighters, being the first responders, are frequently exposed to heat which may impact their immune system and ove…
View article: Deciphering the role of fruit maturity, calcium and freezing on the nutritional and textural attributes of crisps from red guava
Deciphering the role of fruit maturity, calcium and freezing on the nutritional and textural attributes of crisps from red guava Open
Guava (Psidiumguajava L.), being highly nutritious possesses commercial importance in the tropical and subtropical region of the world. The climacteric guava, however, records highest postharvest loss and needs to be processed for higher s…
View article: #1731 Clinico-epidemiological characteristics of early versus late onset cytomegalovirus disease among renal transplant recipients: two decade experience
#1731 Clinico-epidemiological characteristics of early versus late onset cytomegalovirus disease among renal transplant recipients: two decade experience Open
Background and Aims The epidemiology of the Cytomegalo virus (CMV) disease among renal transplant recipients has changed with the advent of effective antiviral prophylaxis usually occurs in the later part of the post transplant period. To …
View article: #1718 Infectious complications among early versus late pulse steroid therapy among renal transplant recipients
#1718 Infectious complications among early versus late pulse steroid therapy among renal transplant recipients Open
Background and Aims Renal transplant recipients are at risk for infectious complications, with opportunistic infections predominating early after transplant and community acquired infections occurring in late transplant period. Pulse stero…
View article: The Miracle of Xenotransplants: Are We Ready for Prime Time?
The Miracle of Xenotransplants: Are We Ready for Prime Time? Open
Xenotransplantation represents a groundbreaking advancement in medical science, offering a beacon of hope for countless individuals suffering from end-stage kidney disease (ESKD). For history enthusiasts, the first successful clinical xeno…
View article: Urinary Mitochondrial DNA Induces an Inflammatory Response in Peripheral Blood Mononuclear Cells
Urinary Mitochondrial DNA Induces an Inflammatory Response in Peripheral Blood Mononuclear Cells Open
Background: Mitochondria are semiautonomous cell organelles having its own nucleic acid. Mitochondrial DNA (Mt-DNA) remain in hypomethylated (CpG) state and impose an immunogenic response by binding to the toll-like receptor (TLR-9) throug…
View article: WCN24-2365 Overhydration and malnutrition assessed by BIA in End Stage Renal Disease: a double whammy for patients on hemodialysis in resource-poor settings
WCN24-2365 Overhydration and malnutrition assessed by BIA in End Stage Renal Disease: a double whammy for patients on hemodialysis in resource-poor settings Open
Overall mortality in ESRD patients on MHD is approximately 20-30%, primarily due tocardiovascular disease and infections. Overhydration (OH) is a risk factor for cardiac dysfunction – leading toleft ventricular hypertrophy (LVH), myocardia…
View article: Successful pervaginal management of Schistosoma reflexus in buffalo: A case report
Successful pervaginal management of Schistosoma reflexus in buffalo: A case report Open
The present case reports the successful per-vaginal delivery of Schistosoma reflexus fetus using Thygeson's fetotome. A nine-year-old Murrah buffalo of the sixth parity with an extended gestation period (11 months) was presented to the TVC…
View article: Oro-Respiratory Dysbiosis and Its Modulatory Effect on Lung Mucosal Toxicity during Exposure or Co-Exposure to Carbon Nanotubes and Cigarette Smoke
Oro-Respiratory Dysbiosis and Its Modulatory Effect on Lung Mucosal Toxicity during Exposure or Co-Exposure to Carbon Nanotubes and Cigarette Smoke Open
The oro-respiratory microbiome is impacted by inhalable exposures such as smoking and has been associated with respiratory health conditions. However, the effect of emerging toxicants, particularly engineered nanoparticles, alone or in co-…
View article: Noninvasive Colour-Based Card for Risk Assessment of Anaemia in Children: PAN-India User Experience
Noninvasive Colour-Based Card for Risk Assessment of Anaemia in Children: PAN-India User Experience Open
Background: Easy-to-use inexpensive tools are needed for the detection and timely intervention for anemia in children. As an extension of an earlier user-experience in 9 paediatricians, we present real-world experience of 84 paediatricians…
View article: Epidemiological, cytological, and haemato-serological analysis of canine mammary gland tumours
Epidemiological, cytological, and haemato-serological analysis of canine mammary gland tumours Open
When it comes to neoplastic situations, a clear and early diagnosis is crucial for both human and animal patients to determine the best course of therapy and improved prognosis. The study's objective was to analyse the epidemiological, cyt…
View article: Dystocia due to Incomplete Cervical Dilatation in Goat and its Non-Surgical Management
Dystocia due to Incomplete Cervical Dilatation in Goat and its Non-Surgical Management Open
A four-year-old non-descript doe in her third parity was presented to Referral Veterinary Polyclinic, ICAR-IVRI with a clinical history of failure to deliver kid even after completion of the gestation period. The doe was showing intermitte…
View article: Cystic Endometrial Hyperplasia and Pyometra Complex in a Bitch
Cystic Endometrial Hyperplasia and Pyometra Complex in a Bitch Open
A 11 years old German Shepherd bitch with the history of abdominal distension, vomiting, and purulent vaginal dis charge was presented to Veterinary Clinical Complex, DUVASU, Mathura. Haematological examination revealed increase in total e…
View article: Enhancing AI Device Security and Efficiency Through Nanotechnology in Cybersecurity and Cloud Integration
Enhancing AI Device Security and Efficiency Through Nanotechnology in Cybersecurity and Cloud Integration Open
The Internet of Things (IoT) has critical repercussions for the transport sector.Autonomous vehicles (AVs) are intended to improve everyday jobs such as freight transportation, traffic patterns, and the flow of wares.AVs are not constraine…