Tadeusz Pietras
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View article: Intranasally Administered Insulin as Neuromodulating Factor and Medication in Treatment of Neuropsychiatric Disorders—Current Findings from Clinical Trials
Intranasally Administered Insulin as Neuromodulating Factor and Medication in Treatment of Neuropsychiatric Disorders—Current Findings from Clinical Trials Open
As a metabolism-controlling peptide, insulin affects activity of almost all tissues in human organisms, including the ones located in the central nervous system. By modifying glucose uptake and processing, as well as inducing anabolic effe…
View article: Comparison of High-Charge Protocol vs. Dose Titration Protocol in Bilateral ECT: Evaluation of Antidepressant Effectiveness and EEG Parameters
Comparison of High-Charge Protocol vs. Dose Titration Protocol in Bilateral ECT: Evaluation of Antidepressant Effectiveness and EEG Parameters Open
Objectives: Recently, we modified the method of dosing charge in daily practice for patients undergoing bilateral electroconvulsive treatment (BL ECT). The aim of this study is to compare the effectiveness of two charges’ dosing protocols—…
View article: Thyroid Hormone Pathways in Respiratory Diseases: Mechanism and Therapeutic Potential
Thyroid Hormone Pathways in Respiratory Diseases: Mechanism and Therapeutic Potential Open
Thyroid hormones (THs) influence a wide range of processes, from gene expression to complex signaling pathways, in almost every tissue. Over the past few years, there has been renewed interest in the TH synthesis, metabolism, secretion, an…
View article: The Association Between Mental Health Indices and the Chronotypes Measured by Single-Item Chronotyping in Young Adults
The Association Between Mental Health Indices and the Chronotypes Measured by Single-Item Chronotyping in Young Adults Open
Background: Chronotype reflects individual variations in daily activity and sleep patterns, influenced by underlying circadian rhythms. While chronotype is often reduced to the morningness–eveningness spectrum, recent evidence suggests mor…
View article: Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results
Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results Open
Findings from our novel study indicate that DIO and proinflammatory cytokines are possibly involved in the mechanisms underlying processes related to COPD, including immune-endocrine interaction. These can be discussed for further evaluati…
View article: Structure of Patients’ Temperament Traits as a Risk Factor for Anxiety and Depression in Patients with Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Structure of Patients’ Temperament Traits as a Risk Factor for Anxiety and Depression in Patients with Asthma and Chronic Obstructive Pulmonary Disease (COPD) Open
Introduction: Asthma and chronic obstructive pulmonary disease (COPD) are chronic respiratory illnesses frequently accompanied by anxiety and depression. These psychological symptoms often go undetected due to their overlap with somatic co…
View article: Effect of clozapine and olanzapine on the production of malondialdehyde in reaction to free radical attack on deoxyribose
Effect of clozapine and olanzapine on the production of malondialdehyde in reaction to free radical attack on deoxyribose Open
Introduction Clozapine and olanzapine are among the most effective antipsychotic drugs. However, their use is associated with the development of metabolic syndrome and lipid profile disorders. It is therefore interesting whether they can a…
View article: People with symptoms of depression and those at significant risk of suicide show differences in their personality profile and sense of meaning in life
People with symptoms of depression and those at significant risk of suicide show differences in their personality profile and sense of meaning in life Open
Introduction Medical students are exposed to various stressors. Among the many factors that determine the possibility of a mental crisis, there is also a personality profile and a sense of meaning in life. Materials and methods Sets of ano…
View article: Temperament traits as predictors of depression and anxiety in patients with asthma and COPD
Temperament traits as predictors of depression and anxiety in patients with asthma and COPD Open
Introduction: The aim of this study was to determine the relationship between individual temperament traits among patients with chronic respiratory diseases and the risk of developing symptoms of anxiety and depression in an adult populati…
View article: Stimulation of bed nucleus of the stria terminalis area for treatment-resistant obsessive-compulsive disorder and comorbid depressive and anxiety symptoms: a systematic literature review
Stimulation of bed nucleus of the stria terminalis area for treatment-resistant obsessive-compulsive disorder and comorbid depressive and anxiety symptoms: a systematic literature review Open
Clinical experience with BNST DBS remains limited, with most studies treating trOCD and only two addressing TRD. Reported outcomes suggest reductions in obsessions, compulsions, and affective symptoms, alongside improved daily functioning.…
View article: The influence of student classes in psychiatry on the perception of people with intellectual disabilities
The influence of student classes in psychiatry on the perception of people with intellectual disabilities Open
Aim: To gain knowledge about the attitudes of medical students towards people with intellectual disabilities and the impact of psychiatry teaching on changing these attitudes. Materials and Methods: The study involved 106 students of medic…
View article: Displacement of the deep brain stimulation electrodes implanted in the anterior nucleus of the thalamus due to chronic subdural hematoma
Displacement of the deep brain stimulation electrodes implanted in the anterior nucleus of the thalamus due to chronic subdural hematoma Open
Anterior nucleus of the thalamus deep brain stimulation (ANT DBS) offers a treatment option for patients with drug-resistant epilepsy (DRE). This treatment modality is particularly useful in cases of multifocal DRE originating from the fro…
View article: Thoracic spinal cord compression due to excessive scarring around surgical paddle epidural electrodes. Report of two cases with literature review
Thoracic spinal cord compression due to excessive scarring around surgical paddle epidural electrodes. Report of two cases with literature review Open
To our knowledge, both cases constitute extremely rare complications of SCS therapy resulting in thoracic spinal myelopathy. The predisposing factors found in our patients were surgically placed paddle electrodes with a prior history of IP…
View article: Case Studies on Dissocial Personality—Bad or Ill?
Case Studies on Dissocial Personality—Bad or Ill? Open
Dissocial personality is understood as a personality that does not ideologize most social norms and is characterized by a lack of empathy. Precise criteria for diagnosing dissocial personality are included in the ICD-10 classification, whi…
View article: Dissocial Personality – Bad or Ill? Case Studies
Dissocial Personality – Bad or Ill? Case Studies Open
The aim of modern psychiatry is to help patients with mental disorders. Subjects with dissocial personality usually receive no such assistance, since the social threat they pose forces the society to isolate them in prison. Meanwhile, mode…
View article: PAPP-A protein diagnostic and prognostic significance in acute coronary syndromes without persistent ST-T-segment elevation.
PAPP-A protein diagnostic and prognostic significance in acute coronary syndromes without persistent ST-T-segment elevation. Open
There are ongoing attempts to find a reliable, highly sensitive and specific early indicator of myocardial ischemia. Recently, a potential new function for the “non-pregnancy” related PAPP-A protein has been reported in many papers, includ…
View article: Sense of loneliness and meaning in life in chronic obstructive pulmonary disease patients. Preliminary studies.
Sense of loneliness and meaning in life in chronic obstructive pulmonary disease patients. Preliminary studies. Open
Background: Chronic obstructive pulmonary disease (COPD) interferes with everyday functioning but its impact on the loneliness and the meaning in life of the patients is unclear. Objectives: to determine whether the COPD severity levels co…
View article: What makes medical students choose their residencies? Association between mental health of medical students and their choices of future medical specialties
What makes medical students choose their residencies? Association between mental health of medical students and their choices of future medical specialties Open
Background: Excessive cognitive demands and chronic stress contribute to the occurrence of mental health problems among medical students. It may be hypothesized that the presence of such disturbances have an influence on their choices of p…
View article: Effect of Clozapine and Olanzapine on the Expression of Selected Genes and Epigenetic Regulators of Insulin Resistance Pathway in Human Preadipocytes – a Preliminary Study
Effect of Clozapine and Olanzapine on the Expression of Selected Genes and Epigenetic Regulators of Insulin Resistance Pathway in Human Preadipocytes – a Preliminary Study Open
Clozapine and olanzapine, popular second-generation antipsychotics used for various psychiatric disorders, cause significant side effects such as metabolic syndrome, but the exact mechanism remains unclear. The present study aimed to asses…
View article: The Evaluation of Selected Trace Elements in Blood, Serum and Blood Cells of Type 2 Diabetes Patients with and without Renal Disorder
The Evaluation of Selected Trace Elements in Blood, Serum and Blood Cells of Type 2 Diabetes Patients with and without Renal Disorder Open
Background: An appropriate diet is the basis for the treatment of type 2 diabetes (T2DM). However, there are no strict recommendations regarding the content of micronutrients and their modifications in the presence of chronic kidney diseas…
View article: Deep brain stimulation of hippocampus in treatment of refractory temporal lobe epilepsy
Deep brain stimulation of hippocampus in treatment of refractory temporal lobe epilepsy Open
Hippocampal DBS appears to be a safe and efficacious treatment alternative for patients who are not candidates for temporal lobectomy or selective amygdalohippocampectomy due to serious postoperative cognitive deficits. In selected patient…
View article: Deep brain stimulation of anterior nucleus and centromedian nucleus of thalamus in treatment for drug-resistant epilepsy
Deep brain stimulation of anterior nucleus and centromedian nucleus of thalamus in treatment for drug-resistant epilepsy Open
ANT and CMN DBS appear to be safe and efficacious treatments, particularly in patients with refractory partial seizures and primary generalised seizures. ANT DBS reduces most effectively seizures originating in the temporal and frontal lob…
View article: Systemic concentrations of IL-18, TFG-, RANTES, ICAM-1 and uPAR as combined pathway-related factors may help in identification of patients suffering from depressive disorder
Systemic concentrations of IL-18, TFG-, RANTES, ICAM-1 and uPAR as combined pathway-related factors may help in identification of patients suffering from depressive disorder Open
1. Ruiz NAL, Del Ángel DS, Brizuela NO, et al. Inflammatory process and immune system in major depressive disorder. Int J Neuropsychopharmacol 2022; 25: 46–53. Google Scholar
View article: Music therapy and psychotherapy – complementarity or antagonism in the treatment of patients with mental disorders
Music therapy and psychotherapy – complementarity or antagonism in the treatment of patients with mental disorders Open
Aim: The aim of the paper was to compare the principles of music therapy and psychotherapy, pointing out numerous similarities and differences between these two techniques. Materials and Methods: Resistance is observed, as well as the phen…
View article: The sense of loneliness and meaning in life in post-COVID convalescents—a preliminary study
The sense of loneliness and meaning in life in post-COVID convalescents—a preliminary study Open
Introduction The COVID-19 epidemic has provided opportunity to study the impact of a well-defined severe illness on the development of a depressive episode and the associated sense of loneliness and lack of meaning in life. Materials and M…
View article: The ventral capsule and ventral striatum—Stereotactic targets for the management of treatment-resistant depression. A systematic literature review
The ventral capsule and ventral striatum—Stereotactic targets for the management of treatment-resistant depression. A systematic literature review Open
Background Deep brain stimulation (DBS) is still an experimental treatment modality for psychiatric disorders including treatment-resistant depression (TRD). There is preliminary evidence that stimulation of brain reward circuit structures…