Oliver Laeyendecker
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View article: Investigating the HIV epidemic among Black gay and bisexual men in the Southern United States: Results of the HPTN 096 pilot cross-sectional assessment
Investigating the HIV epidemic among Black gay and bisexual men in the Southern United States: Results of the HPTN 096 pilot cross-sectional assessment Open
Background The HIV Prevention Trials Network (HPTN) 096 study was designed to address the markedly higher rates of HIV incidence among Black men who have sex with men (MSM) in the Southern United States (US). A cross-sectional assessment w…
View article: Patterns of HIV-1 viral load suppression and drug resistance during the dolutegravir transition: a population-based longitudinal study
Patterns of HIV-1 viral load suppression and drug resistance during the dolutegravir transition: a population-based longitudinal study Open
Background Data on the population-scale impact of dolutegravir (DTG)-based HIV regimens in sub-Saharan Africa are extremely limited. We used data from a surveillance cohort in southern Uganda to assess viral suppression and antiretroviral …
View article: HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data
HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data Open
Background Estimating the time since HIV infection (TSI) at population level is essential for tracking changes in the global HIV epidemic. Most methods for determining TSI give a binary classification of infections as recent or non-recent …
View article: Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage Open
Introduction To prioritize and tailor interventions for ending AIDS by 2030 in Africa, it is important to characterize the population groups in which human immunodeficiency virus (HIV) viraemia is concentrating. Methods We analysed HIV tes…
View article: Clinical characterization of acute COVID-19 and Post-COVID-19 Conditions 3 months following infection: A cohort study among Indigenous adults and children in the Southwestern United States
Clinical characterization of acute COVID-19 and Post-COVID-19 Conditions 3 months following infection: A cohort study among Indigenous adults and children in the Southwestern United States Open
Long-term effects of COVID-19 on multiple organ systems have been reported. Indigenous persons experienced disproportionate morbidity and mortality from COVID-19; however, Post-COVID-19 Conditions (PCC) have not been well described in this…
View article: Autoantibodies to interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 in a Ugandan cohort and their relation to SARS-CoV-2 infection
Autoantibodies to interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 in a Ugandan cohort and their relation to SARS-CoV-2 infection Open
Our findings contribute to the limited literature on AAb prevalence in East Africa and suggest that SARS-CoV-2 does not induce these AAbs.
View article: <scp>SARS</scp>‐<scp>CoV</scp>‐2 <scp>IgG</scp> antibodies in <scp>COVID</scp>‐19 convalescent plasma and conventional plasma units
<span>SARS</span>‐<span>CoV</span>‐2 <span>IgG</span> antibodies in <span>COVID</span>‐19 convalescent plasma and conventional plasma units Open
Background The Association for the Advancement of Blood and Biotherapies guidelines recommend the use of high‐titer COVID‐19 convalescent plasma (CCP) for patients with SARS‐CoV‐2 at high risk of disease progression, including those who ar…
View article: The genetic architecture of HIV-1 virulence
The genetic architecture of HIV-1 virulence Open
The virulence of Human Immunodeficiency Virus-1 (HIV-1) is partly determined by viral genetic variation. Finding individual genetic variants affecting virulence is important for our understanding of HIV pathogenesis and evolution of virule…
View article: Strong Association Between HIV Incidence and Herpes Simplex Virus Type 2 in Zambia and South Africa: Prospective Data From the HPTN 071 (PopART) Trial
Strong Association Between HIV Incidence and Herpes Simplex Virus Type 2 in Zambia and South Africa: Prospective Data From the HPTN 071 (PopART) Trial Open
Background Herpes simplex virus type 2 (HSV2) is an important cofactor for HIV acquisition and transmission. Associations between the infections are reexamined in longitudinal data from an HIV prevention trial. Methods The HPTN 071 (PopART…
View article: The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States
The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States Open
SARS-CoV-2 antibody kinetics based on immunologic history is not fully understood. We analyzed anti-spike and anti-nucleocapsid antibody responses following acute infection in a cohort of Indigenous persons. The models of peak concentratio…
View article: Prevalence of Sexually Transmitted Infections Among Transgender Women With and Without HIV in the Eastern and Southern United States
Prevalence of Sexually Transmitted Infections Among Transgender Women With and Without HIV in the Eastern and Southern United States Open
BACKGROUND: Data on the epidemiology of sexually transmitted infections (STIs) among transgender women (TGW) with and without human immunodeficiency virus (HIV) are limited. METHODS: We analyzed baseline data collected from a cohort of adu…
View article: Identification of antibody targets associated with lower HIV viral load and viremic control
Identification of antibody targets associated with lower HIV viral load and viremic control Open
Background High HIV viral loads (VL) are associated with increased morbidity, mortality, and on-going transmission. HIV controllers maintain low VLs in the absence of antiretroviral therapy (ART). We previously used a massively multiplexed…
View article: Discordant performance of mpox serological assays
Discordant performance of mpox serological assays Open
None of the assays could distinguish between mpox-positive and vaccinated samples. The MSD assay targeting the MPXV E8L antigen demonstrated the greatest differentiation between mpox-positive and pre-outbreak negative samples. Our findings…
View article: Hospital readmissions among adults living with and without HIV in the US: findings from the Nationwide Readmissions Database
Hospital readmissions among adults living with and without HIV in the US: findings from the Nationwide Readmissions Database Open
US National Institutes of Health.
View article: Incidence and prevalence of hepatitis C and B infections among men who have sex with men and transgender women enrolled in a United States HIV vaccine trial
Incidence and prevalence of hepatitis C and B infections among men who have sex with men and transgender women enrolled in a United States HIV vaccine trial Open
Background: Rising hepatitis C and B virus (HCV and HBV) rates have been reported in men who have sex with men (MSM) and transgender women (TGW). This study characterizes HCV and HBV infections longitudinally among 2,496 MSM/TGW aged 18–50…
View article: An enhanced cross‐sectional HIV incidence estimator that incorporates prior HIV test results
An enhanced cross‐sectional HIV incidence estimator that incorporates prior HIV test results Open
Incidence estimation of HIV infection can be performed using recent infection testing algorithm (RITA) results from a cross‐sectional sample. This allows practitioners to understand population trends in the HIV epidemic without having to p…
View article: A Potential Screening Strategy to Identify Probable Syphilis Infections in the Urban Emergency Department Setting
A Potential Screening Strategy to Identify Probable Syphilis Infections in the Urban Emergency Department Setting Open
Background Syphilis diagnosis in the emergency department (ED) setting is often missed due to the lack of ED-specific testing strategies. We characterized ED patients with high-titer syphilis infections (HTSIs) with the goal of defining a …
View article: Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage Open
Introduction To prioritize and tailor interventions for ending AIDS by 2030 in Africa, it is important to characterize the population groups in which HIV viraemia is concentrating. Methods We analysed HIV testing and viral load data collec…
View article: HIV Shedding from Male Circumcision Wounds in HIV-Infected Men: A Prospective Cohort Study
HIV Shedding from Male Circumcision Wounds in HIV-Infected Men: A Prospective Cohort Study Open
A randomized trial of voluntary medical male circumcision (MC) of HIV—infected men reported increased HIV transmission to female partners among men who resumed sexual intercourse prior to wound healing. We conducted a prospective observati…
View article: The Role of Viral Introductions in Sustaining Community-Based HIV Epidemics in Rural Uganda: Evidence from Spatial Clustering, Phylogenetics, and Egocentric Transmission Models
The Role of Viral Introductions in Sustaining Community-Based HIV Epidemics in Rural Uganda: Evidence from Spatial Clustering, Phylogenetics, and Egocentric Transmission Models Open
Background:It is often assumed that local sexual networks play a dominant role in HIV spread in sub-Saharan Africa. The aim of this study was to determine the extent to which continued HIV transmission in rural communities-home to two-thir…
View article: Erratum for Karaba et al., “Endemic Human Coronavirus Antibody Levels Are Unchanged after Convalescent or Control Plasma Transfusion for Early Outpatient COVID-19 Treatment”
Erratum for Karaba et al., “Endemic Human Coronavirus Antibody Levels Are Unchanged after Convalescent or Control Plasma Transfusion for Early Outpatient COVID-19 Treatment” Open
Volume 14, no. 1, e03287-22, 2023, https://doi.org/10.1128/mbio.03287-22. Page 6, Acknowledgments paragraph 3, sentence 1, "K08AI156021, U54CA260491, and R01AI138897" should read "K08AI156021, and R01AI138897" and "(NCI) (U54CA260491)" sho…
View article: Increasing intra- and inter-subtype HIV diversity despite declining HIV incidence in Uganda
Increasing intra- and inter-subtype HIV diversity despite declining HIV incidence in Uganda Open
HIV incidence has been declining in Africa with scale-up of HIV interventions. However, there is limited data on HIV evolutionary trends in African populations with waning epidemics. We evaluated changes in HIV viral diversity and genetic …
View article: Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial
Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial Open
BACKGROUNDCOVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion antibody levels sufficient to prevent disease progression are not defined.METHODSThis secondary analysis correlated d…
View article: Prevalence of Sexually Transmitted Infections Among Transgender Women With and Without HIV in the Eastern and Southern United States
Prevalence of Sexually Transmitted Infections Among Transgender Women With and Without HIV in the Eastern and Southern United States Open
Background Data on the epidemiology of sexually transmitted infections (STIs) among transgender women (TGW) with and without human immunodeficiency virus (HIV) are limited. Methods We analyzed baseline data collected from a cohort of adult…
View article: Longitudinal patterns in indeterminate HIV rapid antibody test results: a population-based, prospective cohort study
Longitudinal patterns in indeterminate HIV rapid antibody test results: a population-based, prospective cohort study Open
Rapid HIV tests are critical to HIV surveillance and universal testing and treatment programs. We assessed longitudinal patterns in indeterminate HIV rapid test results in an African population-based cohort. Prospective HIV rapid antibody …