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View article: Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways
Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways Open
Bone regeneration requires coordinated anabolic and catabolic signaling, yet the interplay between mammalian target of rapamycin complex 1 (mTORC1) and adenosine monophosphate–activated protein kinase (AMPK) pathways remains unclear. This …
Are we all seeing the same thing? Discrepancies between parent-reported and physician-reported positional plagiocephaly severity scores Open
Purpose Positional plagiocephaly (PP) and brachycephaly are conditions characterized by head flattening. There has been a sharp rise in the number of patients diagnosed since the American Academy of Pediatrics initiated the “Back to Sleep”…
View article: Cerebrospinal Fluid Leaks and Healthcare Costs Associated With Tethered Cord Release and Filum Terminale Sectioning
Cerebrospinal Fluid Leaks and Healthcare Costs Associated With Tethered Cord Release and Filum Terminale Sectioning Open
The increased burden and inpatient days needed to place patients in the supine position post-TCR are likely not justified in the setting of comparable CSF leak rates.
Ventriculoperitoneal Shunting Versus Endoscopic Third Ventriculostomy for the Surgical Management of Idiopathic Normal Pressure Hydrocephalus: A Retrospective Cohort Analysis Open
Objective Idiopathic normal pressure hydrocephalus (iNPH) is a chronic condition characterized by ventricular enlargement in the setting of normal opening pressure and presents with gait ataxia, dementia, and urinary incontinence. Surgical…
View article: SURG-11. COMPARATIVE RISK ANALYSIS OF DEVELOPMENT OF ANEMIA IN RADIOTHERAPY-TREATED VS. NON-TREATED MULTIPLE SCLEROSIS PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY
SURG-11. COMPARATIVE RISK ANALYSIS OF DEVELOPMENT OF ANEMIA IN RADIOTHERAPY-TREATED VS. NON-TREATED MULTIPLE SCLEROSIS PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY Open
INTRODUCTION The use of RT in patients who are diagnosed with multiple sclerosis (MS) is controversial due to adverse effects such as inflammation. Simultaneously, the relationship between oncologic RT and worsening anemia is well establis…
View article: High-Throughput Bioprinting of Spheroids for Scalable Tissue Fabrication
High-Throughput Bioprinting of Spheroids for Scalable Tissue Fabrication Open
Tissue biofabrication that replicates an organ-specific architecture and function requires physiologically-relevant cell densities. Bioprinting using spheroids has the potential to create constructs with native cell densities, but its appl…
View article: Pediatric Traumatic Injuries Due to Agrarian Hay-Hole Falls
Pediatric Traumatic Injuries Due to Agrarian Hay-Hole Falls Open
Hay-holes are a design feature in many traditionally built barns that serve as a portal through which stored hay is passed to the lower level where animals are fed. Unfortunately, children sometimes fall through the hay-hole to the concret…
View article: Epidural Steroid Injection Prior to Spinal Surgery: A Step-Wise and Wise Approach
Epidural Steroid Injection Prior to Spinal Surgery: A Step-Wise and Wise Approach Open
This data suggests that epidural steroid injections' anti-inflammatory effects provide benefits before surgery beyond symptomatic relief. Given that the degeneration of spinal pathologies is typically advanced rather than corrected by the …
Lumbar Puncture in Thrombocytopenia: The Floor Is Not Firm Open
Objective Lumbar puncture (LP) is a diagnostic procedure that accesses the spinal subarachnoid space to measure the opening pressure of the cerebrospinal fluid (CSF) and obtain samples of CSF for analysis. Although commonly performed, LPs …
View article: Awake craniotomies in the pediatric population: a systematic review
Awake craniotomies in the pediatric population: a systematic review Open
OBJECTIVE Awake craniotomy (AC) is employed to maximize tumor resection while preserving neurological function in eloquent brain tissue. This technique is used frequently in adults but remains poorly established in children. Its use has be…
View article: First-time tethered cord release among adults with myelomeningocele: an analysis of people in the National Spina Bifida Patient Registry
First-time tethered cord release among adults with myelomeningocele: an analysis of people in the National Spina Bifida Patient Registry Open
OBJECTIVE The authors analyzed the National Spina Bifida Patient Registry (NSBPR), a national registry that tracks the outcomes for people with various forms of spinal dysraphism, to determine the ongoing longitudinal risk for tethered cor…
View article: Pediatric Hydrocephalus in Brazil Public Health System: the Reality of a Developing Country in the Past 13 Years
Pediatric Hydrocephalus in Brazil Public Health System: the Reality of a Developing Country in the Past 13 Years Open
PURPOSE Pediatric hydrocephalus is a significant challenge in neurosurgery, particularly in resource-limited settings. This study focuses on the landscape of pediatric hydrocephalus neurosurgery in Brazil, a developing country, over the pa…
View article: Primary small cell neuroendocrine carcinoma of the petrous apex: a report of an atypical case
Primary small cell neuroendocrine carcinoma of the petrous apex: a report of an atypical case Open
Introduction: The head and neck region is a very uncommon location for small cell neuroendocrine carcinomas (SCNEC), which are notoriously aggressive and have a terrible prognosis. We describe the second case of a poorly differentiated SCN…
View article: Transgenerational epigenetic inheritance of axonal regeneration after spinal cord injury
Transgenerational epigenetic inheritance of axonal regeneration after spinal cord injury Open
Human epidemiological studies reveal that dietary and environmental alterations influence the health of the offspring and that the effect is not limited to the F1 or F2 generations. Non-Mendelian transgenerational inheritance of traits in …
View article: Comparison of <i>in-situ</i> versus <i>ex-situ</i> delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting
Comparison of <i>in-situ</i> versus <i>ex-situ</i> delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting Open
Gene therapeutic applications combined with bio- and nano-materials have been used to address current shortcomings in bone tissue engineering due to their feasibility, safety and potential capability for clinical translation. Delivery of n…
Risk of Glioblastoma Multiforme in Patients Taking Ion Channel Blockers Open
Background Ion channels play a role in the development and progression of glioblastoma multiforme. This study investigates the association between the risk of developing glioblastoma multiforme in patients taking these medications. Methods…
View article: Pregnancy in Spina Bifida Patients: A Comparative Analysis of Peripartum Procedures and Complications
Pregnancy in Spina Bifida Patients: A Comparative Analysis of Peripartum Procedures and Complications Open
Purpose Spina Bifida (S.B.) is caused by a failure in neural tube closure that can present with lower extremity sensory deficits, paralysis, and hydrocephalus. Medical advances have allowed increased pregnancies among S.B. patients, but ma…
View article: Purified neuronal populations of regenerating retinal ganglion cells reveal DNA methylation-mediated role of Na+/K+-ATPase in axon regeneration
Purified neuronal populations of regenerating retinal ganglion cells reveal DNA methylation-mediated role of Na+/K+-ATPase in axon regeneration Open
While embryonic mammalian central nervous system (CNS) axons readily grow and differentiate, only a minority of fully differentiated mature CNS neurons are able to regenerate injured axons, leading to stunted functional recovery after inju…
View article: Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty
Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty Open
The burden of bone fractures demands development of effective biomaterial solutions, while additional acute events such as noncompressible bleeding further motivate the search for multi‐functional implants to avoid complications including …