Sreekantha B. Jonnalagadda
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View article: Green metrics and quality by design tool evaluated UPLC content determination method for Sparsentan in formulation sample
Green metrics and quality by design tool evaluated UPLC content determination method for Sparsentan in formulation sample Open
View article: Algoa Bay sediment metal distribution and potential ecological risk assessment
Algoa Bay sediment metal distribution and potential ecological risk assessment Open
View article: Highly Efficient and Cost-Effective Solid-Base CaO–MgO Catalyst for Knoevenagel Condensation in Water with a Good <i>E</i>-Factor
Highly Efficient and Cost-Effective Solid-Base CaO–MgO Catalyst for Knoevenagel Condensation in Water with a Good <i>E</i>-Factor Open
A cost-effective and eco-compatible 1CaO-1.5MgO binary metal oxide (BMO-1) served as an efficient solid-base catalyst in the Knoevenagel condensation (KC) reaction of a range of aldehydes with active methylene reagents (i) malononitrile an…
View article: Liquid chromatography method for quantification of five impurities in Bilastine tablet formulation; robustness study by design expert
Liquid chromatography method for quantification of five impurities in Bilastine tablet formulation; robustness study by design expert Open
The current work proposes a particular, accurate, simple, and speedy HPLC approach for detecting impurities in Bilastine (BLS) tablet formulations. A gradient mode elution buffer solution (10 mm Potassium dihydrogen phosphate and 10 mm Di-…
View article: Isolation and structural elucidation of an unknown novel impurity in sulfasalazine by high performance liquid chromatography coupled to mass spectroscopy and toxicology prediction
Isolation and structural elucidation of an unknown novel impurity in sulfasalazine by high performance liquid chromatography coupled to mass spectroscopy and toxicology prediction Open
View article: Recent Advances in Synthetic Strategies and Biological Properties of Indazole Scaffolds: A Review
Recent Advances in Synthetic Strategies and Biological Properties of Indazole Scaffolds: A Review Open
Research on heterocyclic compounds is an area of continuous focus, capturing the interest of both synthetic and natural product chemists. Indazoles are one of the rare heterocycles that are available in nature. Indazole and its derivatives…
View article: Novel and efficient synthesis of 5-chloro-6-methoxy-3-(2-((1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzo[d]isoxazole derivatives as new α-glucosidase inhibitors
Novel and efficient synthesis of 5-chloro-6-methoxy-3-(2-((1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzo[d]isoxazole derivatives as new α-glucosidase inhibitors Open
A new series of benzisoxazole derivatives (9a-o) were designed by using molecular hybridization approach and synthesized via click-chemistry. All the synthesized compounds were evaluated for their α-glucosidase enzyme inhibit…
View article: Green synthesis of poly-substituted quinolines catalyzed by CdO@ZrO₂ nanocatalyst
Green synthesis of poly-substituted quinolines catalyzed by CdO@ZrO₂ nanocatalyst Open
A simple, efficient, and highly promising approach for synthesizing poly-substituted quinolines derivatives has been developed using a CdO@ZrO₂ nanocomposite catalyst via the Knoevenagel–Michael reaction. This catalytic system offers sever…
View article: Heptad green metrics and quality by design tool evaluated chromatography method for content determination of Bexagliflozin in formulation product
Heptad green metrics and quality by design tool evaluated chromatography method for content determination of Bexagliflozin in formulation product Open
View article: Utilizing quality by design methodology for liquid chromatography method development and validation in quantifying impurities in Pitolisant, a Histamine-3 (H3) receptor antagonist/inverse agonist
Utilizing quality by design methodology for liquid chromatography method development and validation in quantifying impurities in Pitolisant, a Histamine-3 (H3) receptor antagonist/inverse agonist Open
View article: Pyrimidine fused heterocyclic derivatives: Design, in silico, in vitro, anti-microbial, antidiabetic and anti-biofilm studies
Pyrimidine fused heterocyclic derivatives: Design, in silico, in vitro, anti-microbial, antidiabetic and anti-biofilm studies Open
Pyrimidine-fused derivatives that are an inextricable part of DNA and RNA play a key role in the normal life cycle of cells. Here, we synthesized new pyrimidine-tetrazolo/pyrimidocarboxylic acids (5a-f and 8a-f) with high yields using new …
View article: Combination of Ethylene glycol and TBAB-mediated pyrimidine fused heterocyclic derivatives: Synthesis, in silico, and in vitro anti-diabetic and anti-microbial studies
Combination of Ethylene glycol and TBAB-mediated pyrimidine fused heterocyclic derivatives: Synthesis, in silico, and in vitro anti-diabetic and anti-microbial studies Open
Pyrimidine-fused heterocyclic compounds exhibit pharmacological activity, including anti-diabetic and antibacterial, antifungal properties. This study involves the design and synthesis of pyrimidine-fused heterocyclic compounds in conjunct…
View article: An efficient Cu catalyzed regioselective Ortho-nitration approach for the synthesis of 2-nitroarylcyanamides: Molecular docking and ADME studies
An efficient Cu catalyzed regioselective Ortho-nitration approach for the synthesis of 2-nitroarylcyanamides: Molecular docking and ADME studies Open
View article: A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe <sub>3</sub> O <sub>4</sub> @MWCNT nanocomposite as heterogeneous catalyst
A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe <sub>3</sub> O <sub>4</sub> @MWCNT nanocomposite as heterogeneous catalyst Open
A simple, facile, efficient and highly promising protocol for the synthesis of 1-phenyl-pyrazolo-quinolinone analogs using Fe3O4@MWCNT nano-composite as a catalyst via Knoevenagel–Michael reaction has been developed. The use of Fe3O4@MWCNT…
View article: A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method
A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method Open
The current research presents novel LC-TQ-MS/MS and cost-effective UPLC methods intended for the accurate quantification of NDSRI impurities in mefenamic acid (MFA) tablet and pediatric suspension dosage forms.
View article: Zinc-encapsulating covalent organic frameworks for enhanced chemiresistive NH<sub>3</sub> sensing at room temperature
Zinc-encapsulating covalent organic frameworks for enhanced chemiresistive NH<sub>3</sub> sensing at room temperature Open
A Zn-encapsulating COF sensor (Zn@COF-3) fabricated via a drop-casting method demonstrates a selective and rapid chemiresistive response to NH 3 gas at room temperature, making it suitable for real-time gas sensor applications.
View article: Titanium Dioxide/Graphene‐Based Nanocomposites as Photocatalyst for Environmental Applications: A Review
Titanium Dioxide/Graphene‐Based Nanocomposites as Photocatalyst for Environmental Applications: A Review Open
Nanostructured‐based photocatalysts have always exhibited the potential to solve various environmental issues resulting from global urbanization and industrialization. The creation of nanostructured materials has given humans access to var…
View article: Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and <i>in Vitro</i> Anticancer Studies
Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and <i>in Vitro</i> Anticancer Studies Open
Molecular hybrids of diversely functionalized quinoline and sulfonamide have been designed. Multistep synthetic strategies have been used for the synthesis. The anti‐cancer properties have been evaluated against various cancer cell lines i…
View article: Preparation, Isolation, and Structural Characterization of Lewis Base Iminium Salts of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Their Application as Green Reagents in an Aqueous Medium
Preparation, Isolation, and Structural Characterization of Lewis Base Iminium Salts of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Their Application as Green Reagents in an Aqueous Medium Open
We report a state-of-the-art synthesis and isolation procedure for 13 Lewis base iminium salts (LBI) of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), confirming their structures meticulously by different spectral data. The LBIs are distinct fr…
View article: Synthesis, Docking, and Dynamic Studies of New Pyrano‐[3,2 <i>‐e</i> ]‐Pyrazole Fused 1,2,4‐Triazolo‐[4,3 <i>‐c</i> ]‐pyrimidine Analogues as Anticancer Agents
Synthesis, Docking, and Dynamic Studies of New Pyrano‐[3,2 <i>‐e</i> ]‐Pyrazole Fused 1,2,4‐Triazolo‐[4,3 <i>‐c</i> ]‐pyrimidine Analogues as Anticancer Agents Open
A novel series of dihydropyrazolo‐[4′,3′:5,6]‐pyrano[3,2 ‐e ][1,2,4]triazolo[4,3 ‐c ]‐pyrimidine analogues were designed, synthesized, and their cytotoxic potential against four tumor cell lines assessed. HRMS, 1 H NMR, and 13 C NMR spectr…
View article: Coumarin‐Tethered‐1,2,3‐Triazoles: Synthesis, Characterization, Antimicrobial Evaluation, and DFT Studies
Coumarin‐Tethered‐1,2,3‐Triazoles: Synthesis, Characterization, Antimicrobial Evaluation, and DFT Studies Open
A new series of Coumarin‐tethered‐1,2,3‐triazoles ( 7a–i and 9a–f ) were synthesized by the copper‐assisted 1,3‐dipolar cycloaddition reaction of coumarin alkyne ( 5 ) with variedly substituted azides ( 6a–I and 8a–f ). All the synthesized…
View article: Exploring Novel Coumarin‐Tethered Bis‐Triazoles: Apoptosis Induction in Human Pancreatic Cancer Cells, Antimicrobial Effects, and Molecular Modelling Investigations
Exploring Novel Coumarin‐Tethered Bis‐Triazoles: Apoptosis Induction in Human Pancreatic Cancer Cells, Antimicrobial Effects, and Molecular Modelling Investigations Open
In the present study, we identified that two representative compounds ( 7 c and 9 f ) of our newly synthesized coumarin‐tagged bis‐triazoles induced apoptosis in human pancreatic cells (PANC‐1) by caspase 3/7mediated pathway. Both 7 c and …
View article: Stable Diamine Functionalized Graphene Supported Pd Nanoparticles Showing Excellent Catalytic Activity For Mizoroki–Heck Coupling Reactions
Stable Diamine Functionalized Graphene Supported Pd Nanoparticles Showing Excellent Catalytic Activity For Mizoroki–Heck Coupling Reactions Open
We used a simple technique to create palladium nanoparticles on diamine functionalised graphene (Pd(0)‐AAPTMS@G) with an average particle size of 5.5 nm. Our earlier research described the Pd(0)‐AAPTMS@G material as an effective catalyst w…
View article: A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe<sub>3</sub>O<sub>4</sub>‐MWCNT@MnO<sub>2</sub> as a reusable catalyst
A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe<sub>3</sub>O<sub>4</sub>‐MWCNT@MnO<sub>2</sub> as a reusable catalyst Open
This work aims to explore the catalytic potential of manganese oxide (MnO 2 ) supported on (Fe 3 O 4 ‐MWCNT) nano‐composite, which is composed of iron oxide and multi‐walled carbon nanotubes. The nano‐composite was synthesized using a simp…
View article: Quality by Design Tool Assessed Ultraperformance Liquid Chromatography Method for the Analysis of Remogliflozin and Teneligliptin in Oral Dosage Form
Quality by Design Tool Assessed Ultraperformance Liquid Chromatography Method for the Analysis of Remogliflozin and Teneligliptin in Oral Dosage Form Open
The UPLC methodology was used to establish a method for determining the qualitative and quantitative content of teneligliptin and remogliflozin tablets in oral solid dose form, as no simultaneous method was available. The developed liquid …
View article: Development of Molybdenum oxide Promoted CeO <sub>2</sub> −SiO <sub>2</sub> Mixed‐oxide Catalyst for Efficient Catalytic Oxidation of Benzylamine to N‐Benzylidenebenzylamine
Development of Molybdenum oxide Promoted CeO <sub>2</sub> −SiO <sub>2</sub> Mixed‐oxide Catalyst for Efficient Catalytic Oxidation of Benzylamine to N‐Benzylidenebenzylamine Open
This study explores a rational synthesis of a molybdenum‐promoted Ce−Si mixed oxide catalyst (MoO 3 /CeO 2 −SiO 2 ) to regulate synergies between MoO 3 and SiO 2 dopant on CeO 2 , achieving high selectivity in solvent‐free catalytic oxidat…
View article: Synthesis and Trace-Level Quantification of Mutagenic and Cohort-of-Concern Ciprofloxacin Nitroso Drug Substance-Related Impurities (NDSRIs) and Other Nitroso Impurities Using UPLC-ESI-MS/MS─Method Optimization Using I-Optimal Mixture Design
Synthesis and Trace-Level Quantification of Mutagenic and Cohort-of-Concern Ciprofloxacin Nitroso Drug Substance-Related Impurities (NDSRIs) and Other Nitroso Impurities Using UPLC-ESI-MS/MS─Method Optimization Using I-Optimal Mixture Design Open
Globally, the pharmaceutical industry has been facing challenges from nitroso drug substance-related impurities (NDSRIs). In the current study, we synthesized and developed a rapid new UPLC-MS/MS method for the trace-level quantification o…
View article: RETRACTED: Microwave-assisted synthesis of triazine covalent organic frameworks <i>via</i> friedel-crafts reaction for use in treating brackish Water
RETRACTED: Microwave-assisted synthesis of triazine covalent organic frameworks <i>via</i> friedel-crafts reaction for use in treating brackish Water Open
This proceeding volume has been retracted from the publication because we found some solid reasons to believe that it has infringed our integrity criteria and now presents a risk for our journal and scholarly science in general. Different …
View article: Dual active pyrimidine-based carbocyclic nucleoside derivatives: synthesis, and <i>in silico</i> and <i>in vitro</i> anti-diabetic and anti-microbial studies
Dual active pyrimidine-based carbocyclic nucleoside derivatives: synthesis, and <i>in silico</i> and <i>in vitro</i> anti-diabetic and anti-microbial studies Open
New pyrimidine-based carbocylic nucleoside derivatives with C-4 substitution for inhibiting α-glucosidase as a means of alleviating the effects of diabetes mellitus (DM) and microbial infections.
View article: The Emergence of CaO-MgO based Binary Oxides of Alkaline Earth Metals as Cost-effective Solid Base Heterogeneous Catalysts and Sorbents: (A Mini Review)
The Emergence of CaO-MgO based Binary Oxides of Alkaline Earth Metals as Cost-effective Solid Base Heterogeneous Catalysts and Sorbents: (A Mini Review) Open
The mono or single oxides of alkaline earth metals such as CaO and MgO are a type of non-toxic and non-corrosive solid-base heterogeneous catalysts. Nevertheless, these mono oxide particles can agglomerate and form larger and less active p…