Bharat Thyagarajan
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View article: Asian Americans & Racism: Individual and Structural Experiences (ARISE) pilot study: Feasibility of harmonizing data collection and blood collection for linguistically and culturally diverse Asian Americans for Alzheimer's Disease research
Asian Americans & Racism: Individual and Structural Experiences (ARISE) pilot study: Feasibility of harmonizing data collection and blood collection for linguistically and culturally diverse Asian Americans for Alzheimer's Disease research Open
Background Asian Americans (ASAs) are one of the fastest growing racial groups in the U.S. since 2000, with population projections surpassing 24 million by 2030. However, ASAs remain significantly underrepresented in research, including in…
View article: Effects on blood neurodegeneration biomarkers of a randomized hearing rehabilitation intervention: ACHIEVE Clinical Trial update
Effects on blood neurodegeneration biomarkers of a randomized hearing rehabilitation intervention: ACHIEVE Clinical Trial update Open
Background The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized trial ( n = 977;ClinicalTrials.gov:NCT03243422) demonstrated that hearing intervention slowed 3‐year cognitive decline by 48% among a subgroup of participa…
View article: Gene‐centric analysis using functional annotation identifies genetic associations with blood‐based biomarkers of Alzheimer's disease in older adults from India
Gene‐centric analysis using functional annotation identifies genetic associations with blood‐based biomarkers of Alzheimer's disease in older adults from India Open
Background Alzheimer's disease (AD) and related dementias are a growing health and economic burden in India, the most populous country in the world. Blood levels of amyloid beta (Aß), tau, and other proteins marking neuronal injury are bio…
View article: Genetic variants in <i>MAPT</i> are associated with Alzheimer's disease blood biomarkers in South Asians from the Longitudinal Aging Study in India‐Diagnostic Assessment of Dementia
Genetic variants in <i>MAPT</i> are associated with Alzheimer's disease blood biomarkers in South Asians from the Longitudinal Aging Study in India‐Diagnostic Assessment of Dementia Open
Background Alzheimer's disease (AD) is characterized by abnormal blood levels of specific proteins associated with amyloid plaques, tau pathology, and neurodegeneration, which are considered biomarkers of AD. To better understand the genet…
View article: Associations between neurodegenerative plasma biomarkers and cognitive functioning and decline in India
Associations between neurodegenerative plasma biomarkers and cognitive functioning and decline in India Open
Background Mounting evidence supports the use of blood‐based neurodegenerative biomarkers as a low‐cost, minimally invasive tool for studying dementia, but existing data largely come from clinical samples or high‐income settings. Despite e…
View article: Audiometric hearing and plasma biomarkers of Alzheimer's disease pathology and neurodegeneration in the Atherosclerosis Risk in Communities Neurocognitive Study
Audiometric hearing and plasma biomarkers of Alzheimer's disease pathology and neurodegeneration in the Atherosclerosis Risk in Communities Neurocognitive Study Open
Background Hearing loss is an established risk factor for Alzheimer's disease and related dementias (ADRD) but the mechanism is unknown. We investigated the cross‐sectional association of hearing loss with plasma AD/ADRD biomarkers, hypoth…
View article: Alzheimer Disease Blood Biomarker Concentrations Across Race and Ethnicity Groups in Middle-Aged Adults
Alzheimer Disease Blood Biomarker Concentrations Across Race and Ethnicity Groups in Middle-Aged Adults Open
Importance The incidence and prevalence of clinical Alzheimer disease (AD) are higher among Black and Latinx older adults than among White older adults. Past studies that compared plasma AD biomarker concentrations among groups minoritized…
View article: Cross-sectional associations between lifecourse dementia risk factors, plasma neurodegenerative biomarkers, and cognition in older adults in India
Cross-sectional associations between lifecourse dementia risk factors, plasma neurodegenerative biomarkers, and cognition in older adults in India Open
BACKGROUND Plasma neurodegenerative biomarkers are a potential low-cost tool for studying Alzheimer’s disease and dementia in population-based research, especially in low- and middle-income countries (LMIC). However, their associations wit…
View article: Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos
Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos Open
Due to the paucity of longitudinal DNA methylation data (DNAm), especially among Hispanic/Latino adults, the association between changes in epigenetic clocks over time and cognitive aging phenotypes has not been investigated. This longitud…
View article: Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults
Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults Open
Importance Subjective cognitive decline (SCD) may be an early indicator of Alzheimer disease and related dementias (ADRD), yet its association with plasma biomarkers remains unclear among middle-aged and older adults (aged 50-86 years). Ob…
View article: Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos
Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos Open
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) prevalence is greater among Hispanics/Latinos than other racial/ethnic groups and prevalence is further reported to vary among Hispanic/Latino background groups. Experimental animal and…
View article: Association of blood-based neurodegenerative biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS)
Association of blood-based neurodegenerative biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS) Open
This study examines associations between blood-based neurodegenerative biomarkers and cognitive functioning in nationally representative samples of older adults in India and the United States. Using data from the Longitudinal Aging Study i…
View article: Dietary Patterns, Circulating Metabolome, and Risk of Type 2 Diabetes
Dietary Patterns, Circulating Metabolome, and Risk of Type 2 Diabetes Open
Circulating metabolites may reflect biological homeostasis and have been linked to dietary intakes and human health, and may hold the promises to facilitate objective assessments of intakes and metabolic response to diets. Here, we integra…
View article: Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results
Metabolic Syndrome and Neurocognition Among Diverse Middle-Aged and Older Hispanics/Latinos: HCHS/SOL Results Open
OBJECTIVE: Hispanics/Latinos have the highest risks for metabolic syndrome (MetS) in the U.S. and are also at increased risk for Alzheimer disease. In this study, we examined associations among neurocognitive function, MetS, and inflammati…
View article: Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults
Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults Open
Epigenetic age acceleration is associated with circulating biomarkers of AD in Hispanic/Latino adults. The second-generation clock PC-PhenoAge showed strong and consistent associations across all biomarkers, and thus may reflect biological…
View article: Methodology of community-based venous blood specimen collection for the harmonized diagnostic assessment of dementia for the Longitudinal Aging Study in India (LASI-DAD): Wave 2
Methodology of community-based venous blood specimen collection for the harmonized diagnostic assessment of dementia for the Longitudinal Aging Study in India (LASI-DAD): Wave 2 Open
The prevalence of dementia is on the rise, with 60% of dementia cases existing in low- and middle-income countries. In India, the prevalence was reported to be 7.4%. Since the pathophysiology of dementia is multifactorial, the Harmonized L…
View article: Prevalence and Phenotype of Transthyretin Val122Ile Variant in the Hispanic Community Health Study/Study of Latinos
Prevalence and Phenotype of Transthyretin Val122Ile Variant in the Hispanic Community Health Study/Study of Latinos Open
The Val122Ile variant prevalence varied depending on AA proportions among H/Ls and was seen more commonly among Dominicans, highlighting opportunities for preventative hereditary transthyretin amyloid cardiomyopathy screening.
View article: Aging measures and cancer in the Health and Retirement Study (HRS)
Aging measures and cancer in the Health and Retirement Study (HRS) Open
Cancer survivors may have higher biological age (BA) than cancer-free persons (controls). In HRS, we examined the associations of BA with cancer prevalence and mortality. BA was estimated by the Klemera and Doubal method (KDM-BA), phenotyp…
View article: Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA)
Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA) Open
Increasingly, research suggests that aging is a coordinated multi-system decline in functioning that occurs at multiple biological levels. We developed and validated a transcriptomic (RNA-based) aging measure we call Transcriptomic Mortali…
View article: Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia
Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia Open
Rationale We hypothesize that impaired lung function contributes to dementia risk via biological mechanisms reflected in AD/ADRD-related protein biomarkers, and aim to evaluate their role in mediating this relationship. Methods Serum p-Tau…
View article: Influence of Stress, Gender, and Minority Status on Cardiovascular Disease Risk in the Hispanic/Latino Community: Protocol for a Longitudinal Observational Cohort Study
Influence of Stress, Gender, and Minority Status on Cardiovascular Disease Risk in the Hispanic/Latino Community: Protocol for a Longitudinal Observational Cohort Study Open
BACKGROUND: Hispanic/Latino sexual and gender minorities (SGM) are the fastest growing ethnic group of SGM in the United States. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among Hispanics/Latinos. SGM inequi…