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View article: Flavonoids from Cirsium italicum (Savi) DC. reduce reactive oxygen species and modulate histone deacetylase activity in triple-negative breast cancer cells
Flavonoids from Cirsium italicum (Savi) DC. reduce reactive oxygen species and modulate histone deacetylase activity in triple-negative breast cancer cells Open
Purpose: The present study aims to investigate the potential anti-cancer activities of flavonoid compounds from Cirsium italicum (Savi) DC. plants in breast cancer cells. Materials and Methods: MDA-MB-231 triple-negative breast cancer (TNB…
View article: Determination of Biotinidase Enzyme Levels in Umbilical Cord Blood and Comparisons with Dried Blood Spot Testing in Newborns
Determination of Biotinidase Enzyme Levels in Umbilical Cord Blood and Comparisons with Dried Blood Spot Testing in Newborns Open
Aim: Biotinidase deficiency (BD) is an autosomal recessive inherited metabolic disorder caused by enzymatic deficiency. Untreated patients may develop neurologic symptoms, hearing loss, optic atrophy, skin eruptions and/or alopecia. Althou…
View article: Association of Lipoprotein A rs10455872 Polymorphism with Childhood Obesity and Obesity-Related Outcomes
Association of Lipoprotein A rs10455872 Polymorphism with Childhood Obesity and Obesity-Related Outcomes Open
Background/Objectives: Obesity is associated with cardiovascular disease worldwide. An increased lipoprotein A (LpA) level is an independent risk factor for cardiovascular disease in children. Genetic polymorphisms of the LPA gene may play…
View article: Evaluation of the effect of rectus sheath block and transversus abdominis plan block on sevoflurane and fentanyl consumption in laparoscopic cholecystectomy: A randomized controlled study
Evaluation of the effect of rectus sheath block and transversus abdominis plan block on sevoflurane and fentanyl consumption in laparoscopic cholecystectomy: A randomized controlled study Open
Objectives: We aimed to compare the total amount of inhalation anesthesia consumed and the amount of fentanyl used as an additional dose in cases where transversus abdominis plane and rectus sheath blocks were applied for postoperative ana…
View article: Breath of relief: Transforming pediatric asthma care with telemedicine‐guided exercises
Breath of relief: Transforming pediatric asthma care with telemedicine‐guided exercises Open
Background Alternative non‐pharmacological strategies such as breathing exercises can be used in combination with pharmacological treatments. Objective The aim of this randomized, controlled, single‐blind study was to investigate the effec…
View article: Amino Acid Metabolism and Immune Dysfunction in Urea Cycle Disorders: T and B Cell Perspectives
Amino Acid Metabolism and Immune Dysfunction in Urea Cycle Disorders: T and B Cell Perspectives Open
Urea cycle disorders (UCDs) are a group of genetic metabolic conditions characterized by enzyme deficiencies responsible for detoxifying ammonia. Hyperammonemia, the accumulation of intermediate metabolites, and a deficiency of essential a…
View article: Evaluation of T‐cell repertoire by flow cytometric analysis in primary immunodeficiencies with DNA repair defects
Evaluation of T‐cell repertoire by flow cytometric analysis in primary immunodeficiencies with DNA repair defects Open
The group of patients with DNA‐repair‐defects increases susceptibility to infections due to impaired repertoire diversity. In this context, we aimed to investigate the TCRvβ‐repertoire by flow cytometric analysis and its correlation with c…
View article: Benign uterus patolojileri için yapılan histerektomi metodlarının değerlendirilmesi
Benign uterus patolojileri için yapılan histerektomi metodlarının değerlendirilmesi Open
Aim : The aim of this study is to compare the intraoperative and postoperative complications of laparoscopic and abdominal approaches in hysterectomies performed for benign indications in our clinic.Materials and Methods: This is a retrosp…
View article: Opinions of NKU Faculty of Medicine Intern and Resident Doctors on Distance Medicine Education During the COVID-19 Pandemic Period
Opinions of NKU Faculty of Medicine Intern and Resident Doctors on Distance Medicine Education During the COVID-19 Pandemic Period Open
Aim: Throughout world history, people in the pandemic have not only been in danger of their physical health but also seriously affected their mental health. To prevent the spread of the virus during the COVID-19 pandemic, the Council of Hi…
View article: Investigation of Pneumococcus, Influenza, Covid-19 Vaccination Rates and Affecting Factors in Patients aged 65 and over
Investigation of Pneumococcus, Influenza, Covid-19 Vaccination Rates and Affecting Factors in Patients aged 65 and over Open
Objective: This study was planned to determine the vaccination rates and related factors with Pneumococcal, Influenza and Covid-19 vaccines in adults aged 65 and over who applied to the Family Medicine Outpatient Clinic. Methods: The sampl…
View article: Serum Neopterin, Biopterin, Tryptophan, and Kynurenine Levels in Patients with Fabry Disease
Serum Neopterin, Biopterin, Tryptophan, and Kynurenine Levels in Patients with Fabry Disease Open
From the onset of the disease, patients with Fabry disease exhibited elevated levels of inflammation and immune activation. Furthermore, inflammation and immune activation markers can be used as early disease biomarkers.
View article: Myxoma Virus Combination Therapy Enhances Lenalidomide and Bortezomib Treatments for Multiple Myeloma
Myxoma Virus Combination Therapy Enhances Lenalidomide and Bortezomib Treatments for Multiple Myeloma Open
This study aimed to explore the effectiveness and safety of Myxoma virus (MYXV) in MM cell lines and primary myeloma cells obtained from patients with multiple myeloma. Myeloma cells were isolated from MM patients and cultured. MYXV, lenal…
View article: Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness
Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness Open
The aim of this study is to determine the effect of using atypical antipsychotic drug usage at therapeutic doses on daytime sleepiness. One hundred twenty volunteers who met the inclusion-exclusion criteria were divided into two equal grou…
View article: Evaluation of T Cell Repertoire in Primary Immunodeficiencies With Dna Repair Defects
Evaluation of T Cell Repertoire in Primary Immunodeficiencies With Dna Repair Defects Open
Inborn errors of immunity include multiple genetic abnormalities affecting different components of the innate and adaptive immune systems. More than 450 genes have been described so far including DNA repair defects which may result in pred…
View article: B-mode ultrasound assessment of carotid artery structural features in patients with normocalcaemic hyperparathyroidism
B-mode ultrasound assessment of carotid artery structural features in patients with normocalcaemic hyperparathyroidism Open
The findings of this study show that as with asymptomatic primary hyperparathyroidism, normocalcaemic hyperparathyroidism may be associated with increased cardiovascular risk by predisposing to atherosclerosis.
View article: Do Histologically Aggressive Subtypes of Papillary Thyroid Microcarcinoma have Worse Clinical Outcome than Non-Aggressive Papillary Thyroid Microcarcinoma Subtypes? A Multicenter Cohort Study
Do Histologically Aggressive Subtypes of Papillary Thyroid Microcarcinoma have Worse Clinical Outcome than Non-Aggressive Papillary Thyroid Microcarcinoma Subtypes? A Multicenter Cohort Study Open
Histologically aggressive micropapillary thyroid carcinomas (PTMC) subtypes are thought to be associated with an aggressive clinical course. However, evidence for unfavorable clinical outcomes in patients with aggressive PTMC subtypes is n…
View article: Effect of waist circumference and body mass index on the level of spinal anesthesia
Effect of waist circumference and body mass index on the level of spinal anesthesia Open
Background We aimed to determine the effects of waist circumference and body mass index on spinal anesthesia levels. In total, 120 surgical patients who were between 18 and 65 years old and in the American Society of Anesthesiologists’ (AS…
View article: A 5-year surveillance of healthcare-associated infections in a university hospital: A retrospective analysis
A 5-year surveillance of healthcare-associated infections in a university hospital: A retrospective analysis Open
Objectives: “Nosocomial infections” or “healthcare-associated infections” are a significant public health problem around the world. This study aimed to assess the rate of laboratory-confirmed healthcare-associated infections, frequency of …
View article: Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure
Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure Open
Objective:Data on the umbilical cord and postnatal physiological limits of the high sensitivity cardiac troponin T (hs cTnT) in newborns are scarce. This study aims to determine the normal values and upper limits of hs cTnT in healthy newb…
View article: Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure
Evaluation of Two Consecutive High Sensitivity Cardiac Troponin T Measurements in Healthy Newborns and Newborns with Respiratory Failure Open
Objective: Data on the umbilical cord and postnatal physiological limits of the high sensitivity cardiac troponin T (hs cTnT) in newborns are scarce.This study aims to determine the normal values and upper limits of hs cTnT in healthy newb…
View article: Cranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Study
Cranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Study Open
Aim: Silent brain ischemia (SBI), defined as ischemic changes and infarcts without neurologic signs, is an established marker of poor survival. Magnetic resonance imaging (MRI) is useful to define SBI and white matter hyperintensities that…
View article: The association of TSH-receptor antibody with the clinical and laboratory parameters in patients with newly diagnosed Graves’ hyperthyroidism: experience from a tertiary referral center including a large number of patients with TSH-receptor antibody-negative patients with Graves’ hyperthyroidism
The association of TSH-receptor antibody with the clinical and laboratory parameters in patients with newly diagnosed Graves’ hyperthyroidism: experience from a tertiary referral center including a large number of patients with TSH-receptor antibody-negative patients with Graves’ hyperthyroidism Open
According to our study results, TRAb levels at the initial diagnosis of GD are differently associated with clinical and laboratory parameters. Male patients and smoking patients with GD tended to have markedly higher TRAb levels and more s…
View article: Evaluation of Treatment Results with Direct Acting Antiviral Drugs of Cirrhotic/Non-cirrhotic Chronic Liver Disease Caused by Hepatitis C Virus Genotype 1b Infection
Evaluation of Treatment Results with Direct Acting Antiviral Drugs of Cirrhotic/Non-cirrhotic Chronic Liver Disease Caused by Hepatitis C Virus Genotype 1b Infection Open
Amaç: Bu çalışmanın amacı, hepatit C virüs (HCV) genotip 1b'ye bağlı kronik karaciğer hastalığı gelişen olgularda, doğrudan etkili antiviral (DEA) ilaçlar ile yapılan tedavinin virolojik yanıt ve karaciğer fonksiyonlarını değerlendirmek iç…
View article: The effect of gender on response to antithyroid drugs and risk of relapse after discontinuation of the antithyroid drugs in patients with Graves’ hyperthyroidism: A multicenter study
The effect of gender on response to antithyroid drugs and risk of relapse after discontinuation of the antithyroid drugs in patients with Graves’ hyperthyroidism: A multicenter study Open
Male patients with GD have a markedly higher frequency of relapse and poorly controlled disease, as compared to female patients. Larger goiter sizes and higher frequency of smoking may contribute to the higher frequency of relapse and poor…
View article: External Validation of the GREAT Score in Turkish Patients with Gravesʼ Hyperthyroidism Treated with the Titration Regimen Method of Antithyroid Drugs: A Multicenter Study
External Validation of the GREAT Score in Turkish Patients with Gravesʼ Hyperthyroidism Treated with the Titration Regimen Method of Antithyroid Drugs: A Multicenter Study Open
Recently, the Gravesʼ Recurrent Events After Therapy score (GREAT) was proposed as a useful tool to predict relapse before starting antithyroid drugs (ATD) in patients with Gravesʼ disease (GD). Therefore, we intended to assess the validit…
View article: Molecular links between angiogenesis and inflammation in polycystic ovary syndrome
Molecular links between angiogenesis and inflammation in polycystic ovary syndrome Open
Polycystic ovary syndrome (PCOS) is a cause of infertility in women of reproductive age. Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. The aim is to study roles of parameters asso…
View article: Carotid arteries and vertebrobasilary system intracranial stenosis correlates with multi vessel coronary artery disease
Carotid arteries and vertebrobasilary system intracranial stenosis correlates with multi vessel coronary artery disease Open
In patients with severe coronary artery disease especially in 3-VD, CTA scan may be useful diagnostic tool for identifying stenosis of the carotid arteries, particularly in the intracranial segments of the ICA and in the preforaminal (V1) …
View article: Relationship Between Infarct Location and Left Ventricular Rotation Parameters after Acute ST Elevation Myocardial Infarction
Relationship Between Infarct Location and Left Ventricular Rotation Parameters after Acute ST Elevation Myocardial Infarction Open
Detection of apical rotation angle decrease in the early period after STEMI may be useful in predicting extension of infarct scarring to the LV apex.
View article: Can development of atrial fibrillation in patients with ischemic heart failure with low ejection fraction be predicted?
Can development of atrial fibrillation in patients with ischemic heart failure with low ejection fraction be predicted? Open
The triggering factors for AF are increased intracardiac pressures, left atrial dilatation and increased wall tension. As an indicator of increased wall tension, elevated levels of NT-pro BNP predict the development of PAF.