Explanipedia

Editorial: Innovative vaccine strategies for enhanced flavivirus immunization Open

Srinivasa Reddy Bonam · 2025

DNA Vaccines in the Post-mRNA Era: Engineering, Applications, and Emerging Innovations Open

Praveen Neeli, D.L. Chai, Debasmita Roy, Suneel Prajapati, Srinivasa Reddy Bonam · 2025

Deoxyribonucleic acid (DNA) vaccines have re-emerged as a versatile and scalable platform by advances in synthetic biology and delivery systems, positioning them as powerful tools in the post-mRNA vaccine era. Historically considered less …

Mechanistic insights and <i>in vivo</i> HIV suppression by the BRD4-targeting small molecule ZL0580 Open

Naveen Kumar, Zonghui Ma, Fuquan Long, Srinivasa Reddy Bonam, Hsien‐Tsung Lai , et al. · 2025

Epigenetic suppression and durable silencing of HIV represent a promising strategy to achieve ART-free remission, consistent with the “block and lock” HIV cure paradigm. BRD4 is a host epigenetic reader and plays a critical role in HIV tra…

Regulation of immune cell metabolism by therapeutic normal IgG intravenous immunoglobulin Open

Naresh Rambabu, Fawaz Alzaïd, Boban D Anđelković, Sruthi Vijaya Retnakumar, Anupama Karnam , et al. · 2025

Phytochemicals Targeting Inflammatory Pathways in Alcohol-Induced Liver Disease: A Mechanistic Review Open

Swati Tirunal Achary, Prerna Gupta, Ali H. Rajput, Wanphidabet Sohkhia, Srinivasa Reddy Bonam , et al. · 2025

Alcoholic beverages play a significant role in social engagement worldwide. Excessive alcohol causes a variety of health complications. Alcohol-induced liver disease (ALD) is responsible for the bulk of linked fatalities. The activation of…

mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tract Open

Nicholas C. Hazell, Rachel A. Reyna, Srinivasa Reddy Bonam, Jiani Bei, Naveen Kumar , et al. · 2025

Monoclonal antibodies (mAbs) have been developed as effective biological countermeasures against a range of human diseases. The high cost of antibody production and manufacturing limits its clinical application and widespread use. The mRNA…

In silico evidence of monkeypox F14 as a ligand for the human TLR1/2 dimer Open

Ankita Chakraborty, Nabarun Chandra Das, Parth Sarthi Sen Gupta, Saroj Kumar Panda, Malay Kumar Rana , et al. · 2025

Recent emergence of zoonotic monkeypox virus (Mpox) in human has triggered the virologists to develop plausible preventive measures. Hitherto, our understanding on the mechanism of immunopathogenesis of Mpox infection is elusive. However, …

Biological degradation of graphitic carbon nitride sheets and autophagy induction in macrophages Open

K. Swetha, Anushree Bhatnagar, Manikrishna Lakavathu, Penta Poornima, P. Anandha Ganesh , et al. · 2025

The metal-free graphitic-C 3 N 4 has potential applications in bioimaging and cancer therapy. Hereby, its biodegradability and impact on autophagy induction in immune cells are reported, which could be useful for designing biomedical appli…

A multivalent mRNA-LNP vaccine protects against <i>Clostridioides difficile</i> infection Open

Mohamad‐Gabriel Alameh, Alexa Semon, Nile U. Bayard, Yi‐Gen Pan, Garima Dwivedi , et al. · 2024

Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeting C. difficile toxins and virulence fa…

Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants Open

Renee L. Hajnik, Jessica A. Plante, Srinivasa Reddy Bonam, Grace Rafael, Yuejin Liang , et al. · 2024

Innate and Adaptive Immune Parameters following mRNA Vaccination in Mice Open

Srinivasa Reddy Bonam, Nicholas C. Hazell, Mano Joseph Mathew, Yuejin Liang, Xuxiang Zhang , et al. · 2024

The COVID-19 pandemic has raised the standard regarding the current vaccine development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines have proved their ability to induce strong immunogenicity and protective effica…

Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants Open

Haitao Hu, Renee L. Hajnik, Jessica A. Plante, Srinivasa Reddy Bonam, Grace Rafael , et al. · 2024

A broadly protective vaccine for COVID-19 is needed to end the pandemic and to prevent its future recurrence. While the first-generation, spike-based vaccines are effective against early SARS-CoV-2 strains, the convergent evolution of the …

The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects Open

Bowen Lu, Jing Ming Lim, Boyue Yu, Siyuan Song, Praveen Neeli , et al. · 2024

Vaccines have proven effective in the treatment and prevention of numerous diseases. However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such as complex preparation, limited efficacy, potential risks and …

Referee report. For: Looking in the medicine cabinet: methods for using real-world data to assess the impact of measles, mumps and rubella (MMR) and recombinant adjuvanted varicella-zoster vaccines on coronavirus disease 2019 (COVID-19) prevention and case fatality [version 1; peer review: 1 approved with reservations, 1 not approved] Open

Srinivasa Reddy Bonam · 2024

Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants Open

Zhongfeng Ye, Srinivasa Reddy Bonam, Lindsay G. A. McKay, Jessica A. Plante, Jordyn Walker , et al. · 2023

The emergence of highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that are resistant to the current COVID-19 vaccines highlights the need for continued development of broadly prot…

BRD4 as a potential target for human papillomaviruses associated cancer Open

Abdul Qawee Rani, Srinivasa Reddy Bonam, Jia Zhou, Jenny Li, Haitao Hu , et al. · 2023

Around 99% of cervical cancer and 5%–10% of human cancer are associated with human papillomaviruses (HPV). Notably, the life‐cycle of HPV begins by low‐level infection of the basal cells of the stratified epithelium, where the viral genome…

Corrigendum: IL-3 produced by T cells is crucial for basophil extravasation in hapten- induced allergic contact dermatitis Open

Carole El Hachem, Pierre Marschall, Pierre Hener, Anupama Karnam, Srinivasa Reddy Bonam , et al. · 2023

[This corrects the article DOI: 10.3389/fimmu.2023.1151468.].

Editorial: Women in gastrointestinal cancers, volume II: 2022 Open

Nadia Μ. Hamdy, Lisardo Boscá, Sukh Mahendra Singh, Srinivasa Reddy Bonam, Igor Kišš , et al. · 2023

This editorial presents the inaugural Frontiers in Oncology (FIO) “Women in Gastrointestinal Cancer, volume II: 2022” series of article collections. The Research Topic collection highlights the diversity of research performed across the en…

Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis Open

Chetan Ram, Shobhit Gairola, Shobhit Verma, Madhav Nilakanth Mugale, Srinivasa Reddy Bonam , et al. · 2023

Nephropathy is the most prevalent microvascular disorder in diabetes mellitus. Oxidative stress and inflammatory cascade provoked by the persistent hyperglycemic milieu play integral roles in the aggravation of renal injury and fibrosis. W…

IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis Open

Carole El Hachem, Pierre Marschall, Pierre Hener, Anupama Karnam, Srinivasa Reddy Bonam , et al. · 2023

Basophils have been recognized as a characterized cellular player for Th2 immune responses implicated in allergic diseases, but the mechanisms responsible for basophil recruitment to allergic skin remain not well understood. Using a hapten…

Next-Generation Vaccines Against COVID-19 Variants: Beyond the Spike Protein Open

Srinivasa Reddy Bonam, Haitao Hu · 2023

Vaccines are among the most effective medical countermeasures against infectious diseases. The current Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred the sc…

Use of Honey in Liver Disease Open

Mahendran Sekar, Pei Teng Lum, Srinivasa Reddy Bonam, Siew Hua Gan · 2023

Honey is well known for its antioxidant activity, which can theoretically allow it to quench the formation of resonance-stabilized phenoxyl radicals from free radicals. It has recently been used as a dietary supplement and treatment for a …

Medicinal Benefits of Bee Venom Open

Mahendran Sekar, Pei Teng Lum, Srinivasa Reddy Bonam, Siew Hua Gan · 2023

Bee venom is a transparent and odorless liquid that possesses a variety of pharmacologically active components, including polypeptides, enzymes, and some low-molecular-weight compounds such as sugars, amino acids, minerals and catecholamin…

Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines Open

K. Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, Suresh K. Bhargava , et al. · 2023

Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery. LNPs comprise four different lipids: ionizab…

Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines Open

K Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, Suresh K. Bhargava , et al. · 2023

In the recent days, lipid nanoparticles have been successfully emerged as one of the most advanced technology for highly efficient in vivo delivery of exogenous mRNA, especially for delivery of COVID-19 vaccines. For the vaccines to be suc…

Editorial: Innate immune responses to SARS-CoV-2 in infected and vaccinated individuals Open

Nitin K. Saksena, Pedro A. Reche, Srinivasa Reddy Bonam, Nicasio Mancini · 2023

EDITORIAL article Front. Immunol., 08 February 2023Sec. Vaccines and Molecular Therapeutics Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1141405

THEME: “Vaccines and Vaccine Adjuvants/Immunomodulators for Infectious Diseases” Open

Sruthi Vijaya Retnakumar, Srinivasa Reddy Bonam, Haitao Hu, Jagadeesh Bayry · 2023

The discovery of vaccines has enabled the successful prevention of many deadly infectious diseases, decreased the overall mortality rate, and improved life expectancy worldwide [...]

Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants Open

Camille Chauvin, Laurine Levillayer, Mathilde Roumier, H. Nielly, Claude Roth , et al. · 2023

Although tocilizumab treatment in severe and critical coronavirus disease 2019 (COVID-19) patients has proven its efficacy at the clinical level, there is little evidence supporting the effect of short-term use of interleukin-6 receptor bl…

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance Open

Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam , et al. · 2023

There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Physiologically, they regulate tissue differentiation, signal transduction pathways, cellular activation, proliferation, mot…

Retrospective analysis on the immunopotentiating mechanism of an emulsion-based vaccine adjuvant on human antigen presenting cells Open

Srinivasa Reddy Bonam, Peter Paul Platenburg, Jagadeesh Bayry · 2023

We retrospectively analyzed the immunopotentiating mechanism of an oil-in-water (O/W) emulsion-based vaccine adjuvant LiteVax™ Adjuvant (LVA) that contains CMS (Maltose 4’-monosulphate 1,2,3,6,2’,3’,6’-heptadecanoic acid ester), squalane, …

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