Bhadran Bose
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View article: <scp>CARI</scp> Guidelines Commentary on the <scp>KDIGO</scp> Clinical Practice Guideline for the Management of Glomerular Diseases
<span>CARI</span> Guidelines Commentary on the <span>KDIGO</span> Clinical Practice Guideline for the Management of Glomerular Diseases Open
Aim The KDIGO 2021 Glomerular Disease Guidelines provide updated recommendations on the management of glomerular diseases (GD), with substantial advances made in diagnosis, treatment, and improvement of outcomes for people with GD. Methods…
View article: Erratum to “Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome” [Kidney International Reports Volume 9, Issue 10, October 2024, Pages 3053-3056]
Erratum to “Anticoagulation for the Prevention of Thrombotic Events in Nephrotic Syndrome” [Kidney International Reports Volume 9, Issue 10, October 2024, Pages 3053-3056] Open
[This corrects the article DOI: 10.1016/j.ekir.2024.07.013.].
View article: Changing treatment paradigms for membranous nephropathies
Changing treatment paradigms for membranous nephropathies Open
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in non-diabetic adult population.The immunopathogenesis of MN is mostly related to the presence of anti-phospholipase A2 receptor (PLA2R) antibodies (Ab), howe…
View article: Key Points in Managing PLA2R-Associated Membranous Nephropathy
Key Points in Managing PLA2R-Associated Membranous Nephropathy Open
The therapeutic approach to Primary membranous nephropathy (PMN) typically revolves around the optimisation of anti-proteinuric therapy and cyclophosphamide and corticosteroids (CYC/CS) or rituximab as first-line interventions in those at …
View article: Outcomes of primary membranous nephropathy refractory to immunosuppressants
Outcomes of primary membranous nephropathy refractory to immunosuppressants Open
To the Editor, Primary membranous nephropathy (PMN) is one of the most common causes of adult-onset nephrotic syndrome.The current Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend immunosuppressive therapy for PMN pati…
View article: Focal segmental glomerulosclerosis (FSGS) in pregnancy: The case of a 27-year-old woman with nephrotic syndrome at 22 weeks of gestation
Focal segmental glomerulosclerosis (FSGS) in pregnancy: The case of a 27-year-old woman with nephrotic syndrome at 22 weeks of gestation Open
Nephrotic syndrome (NS) in pregnancy has been associated with poor fetal outcomes. Focal segmental glomerulosclerosis (FSGS) is one of the common causes of NS and can be primary or secondary. However, there are few case reports of FSGS dia…
View article: The outcomes of patients with kidney failure due to focal segmental glomerulosclerosis (FSGS) in Australia and New Zealand: A cohort study using the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA)
The outcomes of patients with kidney failure due to focal segmental glomerulosclerosis (FSGS) in Australia and New Zealand: A cohort study using the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) Open
Background The outcomes of patients with focal segmental glomerulosclerosis (FSGS) on kidney replacement therapy (KRT) have not been well described. This study evaluated the outcomes of patients with kidney failure due to FSGS on KRT inclu…
View article: A Review on Plant-Derived Immunomodulatory Agents: Hopes as an Alternative Medicine in the Management of Immune-Related Disorders
A Review on Plant-Derived Immunomodulatory Agents: Hopes as an Alternative Medicine in the Management of Immune-Related Disorders Open
In humans, the immune system serves as a protective barrier against infection; however, when the immune system is out of balance, it can harm the host. Immunomodulators are chemicals or medications that have been employed in the clinic to …
View article: Trends in the Global Burden of Glomerulonephritis
Trends in the Global Burden of Glomerulonephritis Open
The global burden of CKD is high and rising incessantly. Globally, approximately 700 million people have CKD. CKD is projected to rise in the list of cause of death from the 16th place in 2016 to 5th place in 2040.1 CKD is costly to societ…
View article: Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment
Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment Open
Primary membranous nephropathy (PMN) is one of the common causes of adult-onset nephrotic syndrome and is characterized by autoantibodies against podocyte antigens causing in situ immune complex deposition. Much of our understanding of the…
View article: Predictive Models for Recurrent Membranous Nephropathy After Kidney Transplantation
Predictive Models for Recurrent Membranous Nephropathy After Kidney Transplantation Open
Background. Recurrent membranous nephropathy (MN) posttransplantation affects 35% to 50% of kidney transplant recipients (KTRs) and accounts for 50% allograft loss 5 y after diagnosis. Predictive factors for recurrent MN may include HLA-D …
View article: Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy
Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy Open
ClinicalTrials.gov Identifier: NCT01560052.
View article: Immunosuppression therapy for idiopathic membranous nephropathy: systematic review with network meta-analysis
Immunosuppression therapy for idiopathic membranous nephropathy: systematic review with network meta-analysis Open
Background Idiopathic membranous nephropathy is a common cause of nephrotic syndrome in adults. The Kidney Disease Improving Global Outcomes guidelines recommend rituximab or cyclophosphamide and steroids, or calcineurin inhibitor-based th…
View article: A case of minimal change disease during pregnancy – benefits of early diagnosis and use of corticosteroids
A case of minimal change disease during pregnancy – benefits of early diagnosis and use of corticosteroids Open
Nephrotic syndrome presenting in pregnancy is rare and poses a diagnostic and therapeutic challenge. Timing of renal biopsy is important given the increased risk of bleeding and miscarriage, and the choice of immunosuppression is limited d…
View article: Interventions for post-transplant anaemia in kidney transplant recipients
Interventions for post-transplant anaemia in kidney transplant recipients Open
This protocol has been withdrawn after consultation with the authors. They are no longer able to complete this review.
View article: Postpartum atypical hemolytic uremic syndrome: Evaluating thrombotic microangiopathy in the pregnant woman
Postpartum atypical hemolytic uremic syndrome: Evaluating thrombotic microangiopathy in the pregnant woman Open
Acute kidney injury in women during pregnancy and the puerperium is often ascribed to hypertensive complications of pregnancy, especially pre-eclampsia. However, rarer causes, including atypical hemolytic uremic syndrome (aHUS) can be trig…
View article: Baseline characteristics of patients with atypical haemolytic uraemic syndrome (<scp>aHUS</scp>): The Australian cohort in a global <scp>aHUS</scp> registry
Baseline characteristics of patients with atypical haemolytic uraemic syndrome (<span>aHUS</span>): The Australian cohort in a global <span>aHUS</span> registry Open
Aims To describe the baseline characteristics and treatment of Australian patients diagnosed with atypical haemolytic uraemic syndrome (aHUS) reported to the Global aHUS Registry. Methods Descriptive analysis of the Australian cohort with …
View article: Membranous Nephropathy
Membranous Nephropathy Open
Membranous nephropathy (MN) is a glomerular disease that is the leading cause of nephrotic syndrome in non-diabetic Caucasian adults. MN is most often primary (idiopathic) and the remaining is secondary to systemic disease or exposure to i…
View article: Long-term outcomes of patients with end-stage kidney disease due to membranous nephropathy: A cohort study using the Australia and New Zealand Dialysis and Transplant Registry
Long-term outcomes of patients with end-stage kidney disease due to membranous nephropathy: A cohort study using the Australia and New Zealand Dialysis and Transplant Registry Open
MN was associated with superior survival on dialysis and following kidney transplantation compared to patients with other causes of ESKD, and comparable patient survival compared to patients with other forms of glomerulonephritis. However,…
View article: Outcomes of ESKD patients due to MN v1
Outcomes of ESKD patients due to MN v1 Open
Background: Clinical outcomes of patients with end-stage kidney disease (ESKD) secondary to membranous nephropathy (MN) have not been well described. This study aimed to evaluate patient and/or allograft outcomes of dialysis or kidney tran…
View article: Adenine Phosphoribosyltransferase Deficiency: A Potentially Reversible Cause of CKD
Adenine Phosphoribosyltransferase Deficiency: A Potentially Reversible Cause of CKD Open
Adenine phosphoribosyltransferase (APRT) enzyme deficiency is an important and potentially reversible cause of progressive chronic kidney disease. It is a rare, autosomal recessive disorder that was first described in 19741Simmonds H.A. Va…
View article: Anticoagulation for Atrial Fibrillation in Patients with End- Stage Kidney Disease
Anticoagulation for Atrial Fibrillation in Patients with End- Stage Kidney Disease Open
Atrial fibrillation (AF) is common in patients with kidney disease, with prevalence several times greater than in the general population. Anticoagulation agents are used to prevent thromboembolic events as a consequence of AF. Several rand…
View article: Novel complement factor H gene mutation causing atypical haemolytic uraemic syndrome: early Eculizumab prevents acute dialysis
Novel complement factor H gene mutation causing atypical haemolytic uraemic syndrome: early Eculizumab prevents acute dialysis Open
We describe the clinical course and response to treatment of atypical haemolytic uraemic syndrome (aHUS) in two sisters presenting to our hospital 6 years apart with a novel complement factor H mutation that has not been described previous…