Andrew Atkinson
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View article: Population‐Based Cohort Study for Development of National Retinopathy of Prematurity Screening Criteria
Population‐Based Cohort Study for Development of National Retinopathy of Prematurity Screening Criteria Open
Aim Screening criteria for retinopathy of prematurity (ROP) vary among countries. Early detection of ROP and minimising the burden of screening are important. Methods We analysed data from very preterm infants born in Switzerland between 2…
View article: Facilitation as an effective strategy to reduce excessive antibiotic prophylaxis in Children’s hospitals: A stepped-wedge cluster randomized controlled trial
Facilitation as an effective strategy to reduce excessive antibiotic prophylaxis in Children’s hospitals: A stepped-wedge cluster randomized controlled trial Open
ClinicalTrials.gov ID NCT04366440, https://clinicaltrials.gov/study/NCT04366440?term=OPERATIC&rank=1&tab=history , registered on 04/27/2020.
View article: Characterization of Spirometric Response to Standard-of-care Treatment in Lung Allograft Recipients With Bronchiolitis Obliterans and the Utility of Spirometric Criteria for Rescue Therapy: Implications for the Design of Risk-stratified Clinical Trials
Characterization of Spirometric Response to Standard-of-care Treatment in Lung Allograft Recipients With Bronchiolitis Obliterans and the Utility of Spirometric Criteria for Rescue Therapy: Implications for the Design of Risk-stratified Clinical Trials Open
Background. The spirometric response to standard-of-care (SOC) immunosuppressive therapy for the management of bronchiolitis obliterans syndrome (BOS) has been sparsely reported in the literature. Data from a Medicare-approved Registry wer…
View article: Identification of Surrogate Outcome Biomarkers in Lung Allograft Recipients With Bronchiolitis Obliterans: Implications for Randomized Controlled Trials
Identification of Surrogate Outcome Biomarkers in Lung Allograft Recipients With Bronchiolitis Obliterans: Implications for Randomized Controlled Trials Open
BACKGROUND. We developed a prospective, multicenter “registry” to evaluate the effect of extracorporeal photopheresis for lung transplant recipients who develop chronic lung allograft dysfunction (CLAD) with the bronchiolitis obliterans sy…
View article: Geographic distribution and associated mortality of invasive aspergillosis and mucormycosis among Medicare enrollees in the United States (2008-2015)
Geographic distribution and associated mortality of invasive aspergillosis and mucormycosis among Medicare enrollees in the United States (2008-2015) Open
53,321 patients were diagnosed with invasive aspergillosis, and 2655 had a diagnosis of mucormycosis. The western region of the United States reported the highest incidence rates (aspergillosis: 25.69 cases per 100,000 person-years; mucorm…
View article: Integrating Nonindividual Patient Features in Machine Learning Models of Hospital-Onset Bacteremia
Integrating Nonindividual Patient Features in Machine Learning Models of Hospital-Onset Bacteremia Open
Importance Hospital-onset bacteremia and fungemia (HOB) are common and potentially preventable complications of hospital care. Objective To assess whether nonindividual patient features, which summarize interactions with other patients and…
View article: Outcomes After Arthroscopic Posterior Labral Repair With All-Suture Anchors in Football Players
Outcomes After Arthroscopic Posterior Labral Repair With All-Suture Anchors in Football Players Open
Background: Posterior glenoid labral injuries are more common in football players than in the general population. Arthroscopic repair with all-suture anchors has proven to be an effective technique to address other abnormalities, allowing …
View article: Influence of Disease Type and Activity on Adalimumab Exposure in Children with Inflammatory Rheumatic Diseases
Influence of Disease Type and Activity on Adalimumab Exposure in Children with Inflammatory Rheumatic Diseases Open
Understanding adalimumab pharmacokinetics (PK) in pediatric inflammatory rheumatic diseases (PIRD) could facilitate individualized treatment strategies. This pharmacometric (PMX) analysis, utilizing prospectively collected data, aimed to d…
View article: Outcomes of Glenoid Labral Repair Using All-Suture Anchors
Outcomes of Glenoid Labral Repair Using All-Suture Anchors Open
Background: In recent years, innovation in arthroscopic glenoid labral repair techniques has included the development of all-suture anchors. There are multiple potential advantages of all-suture anchors, including decreased bone removal, a…
View article: 177. AMR-Informed Antibiotic Use Metrics
177. AMR-Informed Antibiotic Use Metrics Open
Background Antimicrobial resistance (AMR) poses a significant public health threat, and efforts are underway to monitor and reduce unnecessary antibiotic usage. The Standardized Antibiotic Administration Ratio (SAAR) measures unit and hosp…
View article: Mental health in children admitted with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): a follow-up study at 6 months of the Swissped-RECOVERY trial
Mental health in children admitted with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): a follow-up study at 6 months of the Swissped-RECOVERY trial Open
Background PIMS-TS presents with features considered to pose a risk for the development of unfavourable long-term mental health outcomes which haven’t been prospectively investigated. These include neurological symptoms (headache, confusio…
View article: Performance of Risk Models for Antimicrobial Resistance in Adult Patients With Sepsis
Performance of Risk Models for Antimicrobial Resistance in Adult Patients With Sepsis Open
Importance The results of prediction models that stratify patients with sepsis and risk of resistant gram-negative bacilli (GNB) infections inform treatment guidelines. However, these models do not extrapolate well across hospitals. Object…
View article: HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015
HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015 Open
Introduction HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB). Methods We in…
View article: Application of the estimand framework for an emulated trial using reference based multiple imputation to investigate informative censoring
Application of the estimand framework for an emulated trial using reference based multiple imputation to investigate informative censoring Open
Background The ICH E9 (R1) addendum on Estimands and Sensitivity analysis in Clinical trials proposes a framework for the design and analysis of clinical trials aimed at improving clarity around the definition of the targeted treatment eff…
View article: Understanding time to peak effect of propofol as sole agent on bispectral index in children aged 2–12 years
Understanding time to peak effect of propofol as sole agent on bispectral index in children aged 2–12 years Open
Background The pharmacodynamics of propofol in children have previously been described with the proprietary bispectral index (BIS) as an effect‐site marker, and it has been suggested that the rate of onset of propofol might be age dependen…
View article: Impact of hydroxyurea on follicle density in patients with sickle cell disease
Impact of hydroxyurea on follicle density in patients with sickle cell disease Open
The impact of hydroxyurea (HU) on the ovarian reserve of female patients with sickle cell disease (SCD) remains poorly elucidated. Only direct histological analysis of ovarian follicle density can effectively evaluate HU’s effect on ovaria…
View article: Poster 169: Preliminary Outcomes of Revision UCL Repair With Suture Tape Augmentation for Failure of Primary UCL Reconstruction in Professional and Collegiate Pitchers
Poster 169: Preliminary Outcomes of Revision UCL Repair With Suture Tape Augmentation for Failure of Primary UCL Reconstruction in Professional and Collegiate Pitchers Open
Objectives: Injury of the ulnar collateral ligament (UCL) is common in baseball players and pitchers, in particular. The gold standard surgical treatment has been UCL reconstruction with autograft, although, UCL repair with collagen-coated…
View article: Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis
Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis Open
Importance Preoperative skin antisepsis is an established procedure to prevent surgical site infections (SSIs). The choice of antiseptic agent, povidone iodine or chlorhexidine gluconate, remains debated. Objective To determine whether pov…
View article: Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use
Novel Patient‐Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced Palatability, Controlled Absorption, and Less Variability: High Potential for Pediatric Use Open
Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, the only available oral formulation is tablets designed for adult patients. A patient‐friendly orodispersible tablet formulation d…
View article: Social Factors Associated With Congenital Syphilis in Missouri
Social Factors Associated With Congenital Syphilis in Missouri Open
Background Congenital syphilis disproportionately affects individuals impacted by adverse social determinants of health. Understanding these determinants may help facilitate holistic care. Methods We performed a retrospective review of mot…
View article: Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland
Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland Open
Objectives In trials of acute severe infections or inflammations frequent administration of non-randomised treatment (ie, intercurrent event) in response to clinical events is expected. These events may affect the interpretation of trial f…
View article: Pharmacokinetics‐Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study
Pharmacokinetics‐Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study Open
Understanding pharmacokinetics (PK) in children is a prerequisite to determine optimal pediatric dosing. As plasma sampling in children is challenging, alternative PK sampling strategies are needed. In this case study we evaluated the suit…
View article: COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children
COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children Open
Data on COVID-19 vaccine acceptability among parents of children with multisystem inflammatory syndrome (MIS-C) are limited. In this cohort of children with MIS-C, enrolled in the Swissped RECOVERY trial (NCT 04826588), comparing intraveno…
View article: Technique and Outcomes of Posterior Cruciate Ligament Repair With Augmentation
Technique and Outcomes of Posterior Cruciate Ligament Repair With Augmentation Open
Background: Posterior cruciate ligament (PCL) injuries to the knee are uncommon, and ideal surgical management of these injuries is unclear. Current surgical techniques include PCL reconstruction with remnant debridement, remnant-preservin…
View article: ICE volume 45 issue 1 Cover and Front matter
ICE volume 45 issue 1 Cover and Front matter Open
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