John B. Williamson
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View article: Neurofilament Light Protein: a marker for injury severity, clinical course and outcome following moderate-severe Traumatic Brain Injury
Neurofilament Light Protein: a marker for injury severity, clinical course and outcome following moderate-severe Traumatic Brain Injury Open
Background: Recent studies demonstrate increased Neurofilament Light (NfL) levels across all types of Traumatic Brain Injury (TBI). We aimed to evaluate the relationship between acute temporal NfL with ICU physiology and outcome. Methods: …
View article: Early cerebrospinal fluid elevations of pTau-217 in severe traumatic brain injury subjects
Early cerebrospinal fluid elevations of pTau-217 in severe traumatic brain injury subjects Open
Introduction Tauopathies, including Alzheimer’s disease (AD), feature abnormal accumulations of hyperphosphorylated Tau protein; however, their biomarker potential in traumatic brain injury (TBI) is not well-defined. This study investigate…
View article: The spectrum of global representations for families of bounded rank and VI-modules
The spectrum of global representations for families of bounded rank and VI-modules Open
A global representation is a compatible collection of representations of the outer automorphism groups of the finite groups belonging to a family $\mathscr{U}$. These arise in classical representation theory, in the study of representation…
View article: Posttraumatic Stress Disorder Content on TikTok: Cross-Sectional Analysis of Popular #PTSD Posts
Posttraumatic Stress Disorder Content on TikTok: Cross-Sectional Analysis of Popular #PTSD Posts Open
Background TikTok became an increasingly popular platform for mental health discussions during a major global stressor (COVID-19 pandemic). On TikTok, content assumed to promote user engagement is delivered in a hyperindividually curated m…
View article: Global representation theory: Homological foundations
Global representation theory: Homological foundations Open
A global representation is a compatible collection of representations of the outer automorphism groups of the groups belonging to some collection of finite groups $\mathscr{U}$. Global representations assemble into an abelian category $\ma…
View article: Functional connectivity in distributed cortical networks associated with semantic processing in healthy older adults
Functional connectivity in distributed cortical networks associated with semantic processing in healthy older adults Open
Objective While word knowledge is typically well-preserved in aging, declines in executive control often observed in older adults may impact access and application of this knowledge. Evidence suggests aging is associated with declines in s…
View article: Post-traumatic stress disorder on TikTok: A cross-sectional analysis of popular #PTSD content quality (Preprint)
Post-traumatic stress disorder on TikTok: A cross-sectional analysis of popular #PTSD content quality (Preprint) Open
BACKGROUND Attentional problems are a non-specific symptom that occurs in both Attention-deficit/hyperactivity disorder (ADHD) and Post-traumatic stress disorder (PTSD). A recent study reported that over 50% of the most-popular content on…
View article: Linked alterations in structure and autoimmunity biomarkers in remote mild-to-moderate TBI: A multi-modal brain imaging study
Linked alterations in structure and autoimmunity biomarkers in remote mild-to-moderate TBI: A multi-modal brain imaging study Open
View article: Preoperative Visual Attention Performance Predicts Postoperative Delirium
Preoperative Visual Attention Performance Predicts Postoperative Delirium Open
Background Preexisting cognitive impairment is a significant risk factor for post operative delirium (POD), and POD increases morbidity and mortality. Disturbances of attention (i.e., ability to direct, focus, sustain, and shift attention)…
View article: The Effects of Single Instance Transcutaneous Vagus Nerve Stimulation on Cognition in MCI: A Randomized, Double‐Blind, Placebo‐Controlled Crossover Trial
The Effects of Single Instance Transcutaneous Vagus Nerve Stimulation on Cognition in MCI: A Randomized, Double‐Blind, Placebo‐Controlled Crossover Trial Open
Background Transcutaneous stimulation of the auricular branch of the vagus nerve (tVNS) was administered to participants diagnosed with mild cognitive impairment (MCI) to improve word‐list memory (primary outcome) and other cognitive skill…
View article: Aging, musical rhythm, and functional connectivity in the brain
Aging, musical rhythm, and functional connectivity in the brain Open
Background Aging associates with decreased functional connectivity between brain regions linked to musical rhythm perception. Producing rhythmic music may result in strengthened functional connectivity of these regions, but more evidence i…
View article: Frontal GABA levels associate with musical rhythm production in healthy aging adults
Frontal GABA levels associate with musical rhythm production in healthy aging adults Open
Changes in neuronal inhibition have been implicated in age-related declines in sensorimotor performance. While indirect evidence suggests that inhibitory mechanisms are also involved in rhythm entrainment, this association has not been tes…
View article: Exploring the evocative qualities of masks’ visual imagery and their associations with adversity and trauma
Exploring the evocative qualities of masks’ visual imagery and their associations with adversity and trauma Open
Introduction Studies suggest a relationship between the emotional evocativeness of visual imagery and viewer responses, however, there is limited understanding of these associations, especially as they relate to viewers’ personal experienc…
View article: Temporal Profile of Serum Neurofilament Light (NF-L) and Heavy (pNF-H) Level Associations With 6-Month Cognitive Performance in Patients With Moderate-Severe Traumatic Brain Injury
Temporal Profile of Serum Neurofilament Light (NF-L) and Heavy (pNF-H) Level Associations With 6-Month Cognitive Performance in Patients With Moderate-Severe Traumatic Brain Injury Open
Objective: Identification of biomarkers of cognitive recovery after traumatic brain injury (TBI) will inform care and improve outcomes. This study assessed the utility of neurofilament (NF-L and pNF-H), a marker of neuronal injury, informi…
View article: A conceptual framework for a neurophysiological basis of art therapy for PTSD
A conceptual framework for a neurophysiological basis of art therapy for PTSD Open
Post-traumatic stress disorder (PTSD) is a heterogeneous condition that affects many civilians and military service members. Lack of engagement, high dropout rate, and variable response to psychotherapy necessitates more compelling and acc…
View article: Parallel Cerebrospinal Fluid and Serum Temporal Profile Assessment of Axonal Injury Biomarkers Neurofilament-Light Chain and Phosphorylated Neurofilament-Heavy Chain: Associations With Patient Outcome in Moderate-Severe Traumatic Brain Injury
Parallel Cerebrospinal Fluid and Serum Temporal Profile Assessment of Axonal Injury Biomarkers Neurofilament-Light Chain and Phosphorylated Neurofilament-Heavy Chain: Associations With Patient Outcome in Moderate-Severe Traumatic Brain Injury Open
Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal…
View article: Regional associations of white matter integrity and neurological, post-traumatic stress disorder and autonomic symptoms in Veterans with and without history of loss of consciousness in mild TBI
Regional associations of white matter integrity and neurological, post-traumatic stress disorder and autonomic symptoms in Veterans with and without history of loss of consciousness in mild TBI Open
Background Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) share overlapping symptom presentations and are highly comorbid conditions among Veteran populations. Despite elevated presentations of PTSD after mTBI,…
View article: Rhythmic musical activities may strengthen connectivity between brain networks associated with aging-related deficits in timing and executive functions
Rhythmic musical activities may strengthen connectivity between brain networks associated with aging-related deficits in timing and executive functions Open
Brain aging and common conditions of aging (e.g., hypertension) affect networks important in organizing information, processing speed and action programming (i.e., executive functions). Declines in these networks may affect timing and coul…
View article: Improved Post-Traumatic Stress Disorder Symptoms and Related Sleep Disturbances after Initiation of Medical Marijuana Use: Evidence from a Prospective Single Arm Pilot Study
Improved Post-Traumatic Stress Disorder Symptoms and Related Sleep Disturbances after Initiation of Medical Marijuana Use: Evidence from a Prospective Single Arm Pilot Study Open
Introduction: Post-traumatic stress disorder (PTSD) is a debilitating disorder experienced by a subgroup of individuals following a life-threatening trauma. Several US states have passed laws permitting the medical use of marijuana (MMJ) b…
View article: 53 Change in Cerebral Metabolite Concentrations Following Bariatric Surgery
53 Change in Cerebral Metabolite Concentrations Following Bariatric Surgery Open
Objective: Obesity is associated with adverse effects on brain health, including increased risk for neurodegenerative diseases. Changes in cerebral metabolism may underlie or precede structural and functional brain changes. While bariatric…
View article: 21 Associations Between Initial Injury Severity, Cerebral Metabolites, and the Local Connectome in Remote Mild-to-Moderate TBI
21 Associations Between Initial Injury Severity, Cerebral Metabolites, and the Local Connectome in Remote Mild-to-Moderate TBI Open
Objective: To determine the association between in-vivo spectroscopy metabolite data, the local connectome, and markers of initial injury severity (I.e., history of loss of consciousness; LoC) in traumatic brain injury (TBI), in a heteroge…
View article: 43 Transcutaneous Vagus Nerve Stimulation Effects on Functional Connectivity of the Hippocampus in Mild Cognitive Impairment
43 Transcutaneous Vagus Nerve Stimulation Effects on Functional Connectivity of the Hippocampus in Mild Cognitive Impairment Open
Objective: Transcutaneous vagus nerve stimulation (tVNS) is a promising potential intervention for Alzheimer's disease (AD) due to its influence on brain functions and mechanisms important in disease progression. Regions of interest includ…
View article: 39 Does Pseudoneglect Modifies The Visuospatial After-Effects Of Vertical Prism Adaptation?
39 Does Pseudoneglect Modifies The Visuospatial After-Effects Of Vertical Prism Adaptation? Open
Objective: The prism adaptation (PA) with rightward shifting lenses is a promising rehabilitation technique for left hemispatial neglect. The PA has also been applied in healthy individuals to investigate cognitive mechanism(s) underlining…
View article: 25 Associations between Diffusion Kurtosis Imaging, Tau, and Cognitive Outcomes in TBI
25 Associations between Diffusion Kurtosis Imaging, Tau, and Cognitive Outcomes in TBI Open
Objective: Determine associations between cognitive outcomes in remote TBI (i.e., at least 6 months post injury), a blood marker of neural degeneration (i.e., Tau), and diffusion kurtosis imaging (DKI) measures (e.g., mean or radial kurtos…
View article: 40 Disorders Of The Anterior Attentional-Intentional System In COVID-19 Survivors - Preliminary Results
40 Disorders Of The Anterior Attentional-Intentional System In COVID-19 Survivors - Preliminary Results Open
Objective: In December 2019, the first reports came from China about cases of pneumonia caused by a previously unknown coronavirus, SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), responsible for a disease called COVID-19. Si…
View article: 9 Serum Neurofilament is Associated with Diffusion Kurtosis Imaging in Chronic Mild-Moderate Traumatic Brain Injury
9 Serum Neurofilament is Associated with Diffusion Kurtosis Imaging in Chronic Mild-Moderate Traumatic Brain Injury Open
Objective: To determine the association between blood markers of white matter injury (e.g., serum neurofilament light and phosphorylated neurofilament heavy) and a novel neuroimaging technique measuring microstructural white matter changes…
View article: Presurgical microstructural coherence predicts cognitive change for bariatric surgery patients
Presurgical microstructural coherence predicts cognitive change for bariatric surgery patients Open
Objective This observational study examined the relationship between presurgical white matter microstructural coherence and cognitive change after weight loss. It was hypothesized that higher baseline fractional anisotropy (FA) would predi…
View article: Issue Information
Issue Information Open
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View article: Carryover and spatial bias effects in Trail Making Test Part A sequential visual search
Carryover and spatial bias effects in Trail Making Test Part A sequential visual search Open
The Trail Making Test (TMT) was designed for the U.S. Army 1944 Individual Test Battery. Norms availability promotes widespread adoption. Part A of two-part TMT (TA) assesses complex attention with a timed task to connect, sequentially, 26…
View article: Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging
Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging Open
Evidence for clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS) has been rapidly accumulating over the past 15 years. This relatively novel non-invasive brain stimulation technique has been applied to a wide ran…