Babak Baban
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View article: Clinical effect of immunomodulatory therapy in periodontitis: a systematic review and meta-analysis
Clinical effect of immunomodulatory therapy in periodontitis: a systematic review and meta-analysis Open
Objectives To evaluate the clinical effect of immunomodulatory therapy in periodontitis, and to identify the possible key inflammatory factors to intervene to modulate the immune status and improve periodontal conditions. Materials and met…
View article: Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control Open
Alzheimer's disease (AD) has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoinflammatory hypothesis of AD suggests chronic immune dysfunc…
View article: Hybrid molecules of ibuprofen and piperidone: a rational approach toward anti-cancer drug development
Hybrid molecules of ibuprofen and piperidone: a rational approach toward anti-cancer drug development Open
The persistent challenge of cancer treatment, exacerbated by multidrug resistance and the limited effectiveness of monotherapies, underscores the need for innovative therapeutic strategies. This study details the design, synthesis, and bio…
View article: T cell knockout attenuates HFD-induced increases in blood pressure in female and male Dahl rats
T cell knockout attenuates HFD-induced increases in blood pressure in female and male Dahl rats Open
Increased body weight is associated with a higher incidence of hypertension in humans. Pre-clinical evidence shows that a high-fat diet (HFD) promotes hypertension. While T cells have been implicated in hypertension, the contribution of T …
View article: A randomized blinded dose–response human biomarker study of remote ischemic conditioning
A randomized blinded dose–response human biomarker study of remote ischemic conditioning Open
BACKGROUND: Remote ischemic conditioning (RIC) is emerging as a simple, inexpensive, and safe intervention for improving systemic vascular health in addition to standard treatments. It involves intermittent ischemic compressions of limbs. …
View article: Protective Role of CBD Against Nicotine Pouch–Induced Seizure Aggravation and Alterations in Brain Glymphatic Biomarkers
Protective Role of CBD Against Nicotine Pouch–Induced Seizure Aggravation and Alterations in Brain Glymphatic Biomarkers Open
Nicotine pouches are increasingly popular as a smokeless alternative to tobacco, yet their long-term neurological effects remain poorly understood. In this preclinical study, we investigated the time-dependent impact of oral nicotine pouch…
View article: Effect of Remote Ischemic Conditioning and Red Blood Cells Biomarkers on Outcomes in Patients With Acute Stroke
Effect of Remote Ischemic Conditioning and Red Blood Cells Biomarkers on Outcomes in Patients With Acute Stroke Open
Background Remote ischemic conditioning (RIC) is a simple and low‐cost intervention that is thought to increase collateral blood flow through the vasodilatory effects of nitric oxide (NO) produced by the endothelium and red blood cells (RB…
View article: Protocatechuic Acid Ameliorates Cisplatin-Induced Inflammation and Apoptosis in Mouse Proximal Tubular Cells
Protocatechuic Acid Ameliorates Cisplatin-Induced Inflammation and Apoptosis in Mouse Proximal Tubular Cells Open
Cisplatin is a highly cytotoxic drug used for the treatment of head, neck, and soft tissue cancers; however, it has nephrotoxic effects that can lead to acute kidney injury. Protocatechuic acid (PCA) is a natural widely available antioxida…
View article: Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control Open
Alzheimer’s disease has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in disease progression. The autoimmune hypothesis of Alzheimer’s disease suggests chronic inflamma…
View article: Optimization of seizure prevention by cannabidiol (CBD)
Optimization of seizure prevention by cannabidiol (CBD) Open
Objective Cannabidiol (CBD) is one of the most prominent non-psychotropic cannabinoids with known therapeutic potentials. Based on its anti-seizure efficacy, the first cannabis derived pharmaceutical grade CBD-based medication was approved…
View article: Suppression of SIGMAR1 hinders oral cancer cell growth via modulation of mitochondrial Ca2+ dynamics
Suppression of SIGMAR1 hinders oral cancer cell growth via modulation of mitochondrial Ca2+ dynamics Open
Oral cancer is the most common malignancy of the oral cavity and facial region, affecting the mucosal and epithelial surfaces in the mouth and lips. Unfortunately, OC is often associated with a high mortality rate and limited treatment opt…
View article: SIGMAR1 Knockdown Enhances Oral Cancer Cell Chemosensitivity to Cisplatin via Decreased PD-L1 Expression
SIGMAR1 Knockdown Enhances Oral Cancer Cell Chemosensitivity to Cisplatin via Decreased PD-L1 Expression Open
Emerging evidence suggests that aberrant expression levels of Sigma1 (SIGMAR1, also known as sigma-1 receptor) have been implicated in the progression of various diseases, including cancer. However, its significance in oral cancer (OC) has…
View article: Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease
Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a challenging medical issue that requires efficacious treatment options to improve long-term quality of life. Cannabidiol (CBD) is a cannabis-derived phytocannabinoid with potential health benefits, including re…
View article: Transcriptome analysis identifies CCDC86 as a new potential Head and Neck Squamous Cell Carcinoma biomarker
Transcriptome analysis identifies CCDC86 as a new potential Head and Neck Squamous Cell Carcinoma biomarker Open
OBJECTIVES: Overall, this comprehensive analysis aims to evaluate the expression profile of CCDC86 in Head and Neck Squamous Cell Carcinoma, providing insights into its potential as a diagnostic biomarker. METHODS: Initially, we conducted …
View article: The role of dietary patterns in the polarization of angiogenic uterine Natural Killer cells during murine pregnancy
The role of dietary patterns in the polarization of angiogenic uterine Natural Killer cells during murine pregnancy Open
Uterine Natural Killer (uNK) cells, predominant leukocytes in mouse and human pregnant uteruses, play crucial roles in angiogenesis and pregnancy protection. In mice, DBA lectin-reactive uNK cells expressing Gal-N-Ac sugar exhibit angiogen…
View article: Cutaneous Wound Healing and the Effects of Cannabidiol
Cutaneous Wound Healing and the Effects of Cannabidiol Open
Cutaneous wounds, both acute and chronic, begin with loss of the integrity, and thus barrier function, of the skin. Surgery and trauma produce acute wounds. There are 22 million surgical procedures per year in the United States alone, base…
View article: Extracellular Vesicles and Diabetic Retinopathy: Nano-Sized Vesicles with Mega-Sized Hopes
Extracellular Vesicles and Diabetic Retinopathy: Nano-Sized Vesicles with Mega-Sized Hopes Open
Diabetic retinopathy (DR) is a major health problem, being the leading cause of vision loss in the working-age group. Novel discoveries facilitating the early diagnosis and curative treatment of DR are still greatly needed. Extracellular v…
View article: The synergy between cannabidiol and probiotics curtails the glycemic indicators, enhances insulin production, and alleviates the symptoms of type 2 diabetes
The synergy between cannabidiol and probiotics curtails the glycemic indicators, enhances insulin production, and alleviates the symptoms of type 2 diabetes Open
Diabetes continues to challenge healthcare system as one of the most growing epidemics with staggering economic burden. It is estimated that 783 million by 2045 will live with diabetes worldwide, 90% of those cases are type 2 diabetes (T2D…
View article: Incorporating Novel Technologies in Precision Oncology for Colorectal Cancer: Advancing Personalized Medicine
Incorporating Novel Technologies in Precision Oncology for Colorectal Cancer: Advancing Personalized Medicine Open
Colorectal cancer (CRC) is one of the most heterogeneous and deadly diseases, with a global incidence of 1.5 million cases per year. Genomics has revolutionized the clinical management of CRC by enabling comprehensive molecular profiling o…
View article: CRISPR/Cas9-Induced Fam83h Knock-out Leads to Impaired Wnt/β-Catenin Pathway and Altered Expression of Tooth Mineralization Genes in Mice.
CRISPR/Cas9-Induced Fam83h Knock-out Leads to Impaired Wnt/β-Catenin Pathway and Altered Expression of Tooth Mineralization Genes in Mice. Open
The concurrent reduction in the expression level of both Wnt/β-catenin mediators and mineralization-related genes, resulting in the disruption of dental mineralization and formation, was caused by the deficiency of Fam83h. Our findings sug…
View article: The Effects of Cisplatin on Gastrostomy Site Healing
The Effects of Cisplatin on Gastrostomy Site Healing Open
Background: Gastrostomy tube placement is sometimes necessary during chemoradiation for head and neck cancer (HNC), but it is associated with worse swallowing outcomes. Despite best efforts, the need for gastrostomy cannot be perfectly pre…
View article: Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice
Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice Open
Emerging evidence shows that the microRNA-141-3p is involved in various age-related pathologies. Previously, our group and others reported elevated levels of miR-141-3p in several tissues and organs with age. Here, we inhibited the express…
View article: Sexual Dimorphism in the Polarization of Cardiac ILCs through Elabela
Sexual Dimorphism in the Polarization of Cardiac ILCs through Elabela Open
Elabela is a component of the apelinergic system and may exert a cardioprotective role by regulating the innate immune responses. Innate lymphoid cells (ILCs) have a significant role in initiating and progressing immune-inflammatory respon…