Ayorinde Babatunde James
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View article: Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial
Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial Open
Fractional dosing of vaccines is a viable strategy to extend COVID-19 vaccine supplies in resource-constrained settings. We did a triple-blinded, multi-site, randomized non-inferiority trial in Nigeria (PACTR202206754734018). Adults 18–65 …
View article: SARS-CoV-2 infection imprints neutralising antibody responses in the absence of vaccination
SARS-CoV-2 infection imprints neutralising antibody responses in the absence of vaccination Open
Immune imprinting refers to a phenomenon where a first viral encounter shapes subsequent immune responses against antigenically distinct variants, favouring the recall of memory B cells against cross‐reactive epitopes in lieu of de novores…
View article: Safety and Immunogenicity of Fractional Doses of COVID-19 Vaccines among Nigerian Adults- A Randomised Non-Inferiority trial
Safety and Immunogenicity of Fractional Doses of COVID-19 Vaccines among Nigerian Adults- A Randomised Non-Inferiority trial Open
The shortage of COVID-19 vaccines posed a significant challenge in optimal response to the COVID-19 pandemic. Fractional doses of vaccine with adequate immunogenic response and proven safety profile emerged as potential strategy to extend …
View article: Anti-SARS-CoV-2 Activity and Acute Toxicity Screening of Annona muricata and Artemisia annua Leaf Extracts
Anti-SARS-CoV-2 Activity and Acute Toxicity Screening of Annona muricata and Artemisia annua Leaf Extracts Open
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Available data suggests that there is no specific treatment in modern medicine. The present study aims to …
View article: A survey of chloroquine use for prevention and treatment of COVID-19 in Nigeria
A survey of chloroquine use for prevention and treatment of COVID-19 in Nigeria Open
Background: Rampant chloroquine/hydroxychloroquine poisoning in Nigerian hospitals following suggestions of its possible efficacy in the treatment and prevention of the newly emerged COVID-19 disease informed this survey.
Objectives: The …
View article: Cytotoxic effects of Curcuma longa leaves on MCF-7 and HepG2 cells
Cytotoxic effects of Curcuma longa leaves on MCF-7 and HepG2 cells Open
Curcuma longa (tumeric) is listed in several therapeutic regimens used in the management of cancer. The present study investigated the potential cytotoxic effects of ethanol extract of Curcuma longa (turmeric) leaves on HepG2 (a human hepa…
View article: Prevalence and Risk Factors of Genital Human Papillomavirus Infections among Women in Lagos, Nigeria
Prevalence and Risk Factors of Genital Human Papillomavirus Infections among Women in Lagos, Nigeria Open
Regional variations exist in HPV prevalence worldwide despite reports of high prevalence rates among African women. Limited data on genital HPV prevalence necessitated this study with the aim of determining the prevalence of genital HPV an…
View article: SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa
SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa Open
Real-world data on vaccine-elicited neutralising antibody responses for two-dose AZD1222 in African populations are limited. We assessed baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior to vaccinati…
View article: SARS-CoV-2 Antibody Responses to AZD1222 Vaccination in West Africa
SARS-CoV-2 Antibody Responses to AZD1222 Vaccination in West Africa Open
There is a paucity of real-world data on vaccine elicited neutralising antibody responses for AZD1222, in African populations following vaccination scale up. Here, we first measured baseline SARS-CoV-2 seroprevalence and levels of protecti…
View article: COVID-19 vaccine breakthrough infections among fully vaccinated Health Care Workers in Lagos, Nigeria
COVID-19 vaccine breakthrough infections among fully vaccinated Health Care Workers in Lagos, Nigeria Open
Background Access to vaccines has contributed to the control of COVID-19. However, evaluation of the effectiveness of the vaccines in a setting where the vaccines were not originally tested is critically important. This study evaluates the…
View article: Surveillance of Viral Hemorrhagic Fever Viruses in Lassa Fever Suspects in Ondo State, Nigeria
Surveillance of Viral Hemorrhagic Fever Viruses in Lassa Fever Suspects in Ondo State, Nigeria Open
Lassa Fever (LF) continues to be an endemic acute viral hemorrhagic fever (VHF) illness in Nigeria. Many suspected cases of LF infection have subsequently been confirmed negative and raises concerns as to what the diagnosis of such patient…
View article: Antibody responses to AZD1222 vaccination in West Africa
Antibody responses to AZD1222 vaccination in West Africa Open
Background There are no real world data on vaccine elicited neutralising antibody responses for the world’s most widely used vaccine, AZD1222, in African populations following scale up. Here, we measured i) baseline SARS-CoV-2 seroprevalen…
View article: The trend of SARS-CoV-2 variants from July 2021 to Jan 2022 in metropolitan Lagos, the epicentre of the COVID-19 pandemic in Nigeria
The trend of SARS-CoV-2 variants from July 2021 to Jan 2022 in metropolitan Lagos, the epicentre of the COVID-19 pandemic in Nigeria Open
Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) exhibits a high mutations rate and monitoring its spread and evolution is essential for global control of the pandemic. This study determined the SARS-CoV-2 variants circulating…
View article: Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria
Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria Open
Background: Access to testing for SARS-CoV-2 in Nigeria is still highly restricted. Only patients who are symptomatic for SARS-CoV-2 are selected for testing. This pattern of testing will miss a large proportion of individuals with the inf…
View article: Enzyme Responsive Vaginal Microbicide Gels Containing Maraviroc and Tenofovir Microspheres Designed for Acid Phosphatase-Triggered Release for Pre-Exposure Prophylaxis of HIV-1: A Comparative Analysis of a Bigel and Thermosensitive Gel
Enzyme Responsive Vaginal Microbicide Gels Containing Maraviroc and Tenofovir Microspheres Designed for Acid Phosphatase-Triggered Release for Pre-Exposure Prophylaxis of HIV-1: A Comparative Analysis of a Bigel and Thermosensitive Gel Open
The challenges encountered with conventional microbicide gels has necessitated the quest for alternative options. This study aimed to formulate and evaluate a bigel and thermosensitive gel, designed to combat the challenges of leakage and …
View article: The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up Open
The first case of COVID-19 in Nigeria was recorded on February 27, 2020, being an imported case by an Italian expatriate, to the country. Since then, there has been steady increase in the number of cases. However, the number of cases in Ni…
View article: Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host
Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host Open
Helminth infections, including hookworms and Schistosomes, can cause severe disability and death. Infection management and control would benefit from identification of biomarkers for early detection and prognosis. While animal models sugge…
View article: Prevalence and Presentation of Paediatric Coronavirus Disease 2019 in Lagos, Nigeria
Prevalence and Presentation of Paediatric Coronavirus Disease 2019 in Lagos, Nigeria Open
Background. The objective of this study was to describe the prevalence and clinical features of coronavirus disease 2019 (COVID-19) among children (≤18 years) evaluated for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infec…
View article: Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion
Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion Open
The present global pandemic triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has lingered for over a year in its devastating effects. Diagnosis of coronavirus disease 2019 (COVID-19) is currently established w…
View article: Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host
Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host Open
Helminth infections, including hookworms and Schistosomes, can cause severe disability and death. Infection management and control would benefit from identification of biomarkers for early detection and prognosis. While animal models sugge…
View article: Prevalence of Factor V Leiden G1691A and Prothrombin G20210A Gene Mutation Among Pregnant Women: Experience from a Multi-Center Study in Nigeria
Prevalence of Factor V Leiden G1691A and Prothrombin G20210A Gene Mutation Among Pregnant Women: Experience from a Multi-Center Study in Nigeria Open
Sarah O John-Olabode,1 Kehinde S Okunade,2 Ayorinde James,3 Gbenga Olorunfemi,4 Obiefuna I Ajie,5 Akinniyi A Osuntoki,6 Alani S Akanmu1 1Department of Hematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Niger…
View article: Prevalence of Factor V Leiden G1691A and Prothrombin G20210A Gene Mutation Among Pregnant Women: Experience from a Multi-Center Study in Nigeria
Prevalence of Factor V Leiden G1691A and Prothrombin G20210A Gene Mutation Among Pregnant Women: Experience from a Multi-Center Study in Nigeria Open
INTRODUCTION: Inherited thrombophilia and venous thromboembolism (VTE) have been closely linked to adverse pregnancy outcomes such as preeclampsia/eclampsia contributing to increased maternal and perinatal morbidity and mortality. There is…
View article: Human Leukocyte Antigen-C and Haplotypes: Associations with Resistance and Susceptibility to HIV-1 Infection among Serodiscordant Couples in Nigeria
Human Leukocyte Antigen-C and Haplotypes: Associations with Resistance and Susceptibility to HIV-1 Infection among Serodiscordant Couples in Nigeria Open
INTRODUCTION The Human Leucocyte Antigen (HLA) class-1 is known to play a significant role in mediating resistance or susceptibility to HIV infection in the clinical course of AIDS. Recent studies have identified HLA-C as a key molecule th…
View article: Comparative performance of SARS-CoV-2 real-time PCR diagnostic assays on samples from Lagos, Nigeria
Comparative performance of SARS-CoV-2 real-time PCR diagnostic assays on samples from Lagos, Nigeria Open
A key element in containing the spread of the SARS-CoV-2 infection is quality diagnostics which is affected by several factors. We now report the comparative performance of five real-time diagnostic assays. Nasopharyngeal swab samples were…
View article: Full length genomic sanger sequencing and phylogenetic analysis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Nigeria
Full length genomic sanger sequencing and phylogenetic analysis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Nigeria Open
In an outbreak, effective detection of the aetiological agent(s) involved using molecular techniques is key to efficient diagnosis, early prevention and management of the spread. However, sequencing is necessary for mutation monitoring and…