Badri Parshad
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View article: Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system
Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system Open
Real-time, quantitative biosensing within extracorporeal perfusion (ECP) and extracorporeal membrane oxygenation (ECMO) systems is key to advancing this life-support technology beyond the hospital setting to emergency care. Measuring and m…
View article: Towards precision medicine using biochemically triggered cleavable conjugation
Towards precision medicine using biochemically triggered cleavable conjugation Open
Personalised and precision medicines are emerging as the future of therapeutic strategies. Biochemically triggered cleavable conjugation is thus crucial and timely due to its potential to response as per the loco-regional environment. It e…
View article: Improved Therapeutic Efficiency of Senescent Cell‐specific, Galactose‐Functionalized Micelle Nanocarriers
Improved Therapeutic Efficiency of Senescent Cell‐specific, Galactose‐Functionalized Micelle Nanocarriers Open
Cellular senescence has recently been recognized as one of the hallmarks of cancer, aging, as well as many age‐related disorders, sparking significant interest in the development of senolytics, compounds that can remove senescent cells. Ho…
View article: Synthesis and Comparison of Linear Polymannosides for Direct Binding with <i>Escherichia coli</i>
Synthesis and Comparison of Linear Polymannosides for Direct Binding with <i>Escherichia coli</i> Open
Here, the synthesis of linear polyglycerols bearing multiple copies of mono and dimannosides (LPG 40 Man 0.60 and LPG 40 (Manα1,2Man) 0.60 ) is demonstrated. A method based on label‐free microscale thermophoresis is optimized to determine …
View article: Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins Open
In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding …
View article: Recent Developments in Nanocatalyzed Green Synthetic Protocols of Biologically Potent Diverse O-Heterocycles—A Review
Recent Developments in Nanocatalyzed Green Synthetic Protocols of Biologically Potent Diverse O-Heterocycles—A Review Open
The dynamic growth in green organic synthetic methodologies for diverse heterocyclic scaffolds has substantially contributed to the field of medicinal chemistry over the last few decades. The use of hybrid metal nanocatalysts (NCs) is one …
View article: Dendritic Polyglycerol‐Conjugated Gold Nanostars for Metabolism Inhibition and Targeted Photothermal Therapy in Breast Cancer Stem Cells
Dendritic Polyglycerol‐Conjugated Gold Nanostars for Metabolism Inhibition and Targeted Photothermal Therapy in Breast Cancer Stem Cells Open
Breast cancer stem cells (CSCs) are believed to be responsible for tumor initiation, invasion, metastasis, and recurrence, which lead to treatment failure. Thus, developing effective CSC‐targeted therapeutic strategies is crucial for enhan…
View article: Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer
Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer Open
Pluronic-polydopamine nanocarriers were used to evaluate the effect of particle size on immunocompatiblity and cell uptake in pancreatic cancer. The drug-loaded carriers exhibited enhanced antiproliferative effects in this hard-to-treat ca…
View article: Polyglycerol-based Hydrogels and Nanogels: From Synthesis to Applications
Polyglycerol-based Hydrogels and Nanogels: From Synthesis to Applications Open
Hydrogels and nanogels have emerged as promising materials for biomedical applications owing to their large surface area and tunable mechanical and chemical properties. Their large surface area is well suited for bioconjugation, whilst the…
View article: Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review
Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review Open
Carbohydrate-based amphiphiles: self-assembled nanostructures of defined size and shape for various biomedical applications.
View article: Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors
Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors Open
A broad-spectrum heteromultivalent influenza inhibitor is developed by using the host cell membrane on an inverted virus scaffold.
View article: Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors Open
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm size…
View article: Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors Open
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm size…
View article: Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action
Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action Open
In this study, we demonstrate the concept of “topology‐matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle‐based inhibitor (nano‐inhibitor) that has a matched nanotopolog…
View article: Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action
Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action Open
In this study, we demonstrate the concept of “topology‐matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle‐based inhibitor (nano‐inhibitor) that has a matched nanotopolog…
View article: Non-ionic small amphiphile based nanostructures for biomedical applications
Non-ionic small amphiphile based nanostructures for biomedical applications Open
Amphiphiles in action: self-assembled nanostructures for drug delivery and imaging.
View article: CCDC 1483452: Experimental Crystal Structure Determination
CCDC 1483452: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications Open
Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesi…
View article: Synthesis and SAR Study of Antioxidant Potential of Polyhydroxy Coumarin Derivatives
Synthesis and SAR Study of Antioxidant Potential of Polyhydroxy Coumarin Derivatives Open
A series of polyhydroxycoumarin derivatives, that are analogs of naturally occurring compounds, have been synthesized and their antioxidant activity (AOA) examined using DPPH, ABTS, and in vitro lipid peroxidation inhibition assays.The SAR…
View article: Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents
Structure–activity relationship studies of 4-methylcoumarin derivatives as anticancer agents Open
This structure-activity relationship (SAR) study of 4-methylcoumarins shows that further investigation of these derivatives may lead to the discovery of novel anticancer agents.