Bahar Golabi
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View article: Dynamic contrast in dual-beam optical coherence tomography imaging of human skin
Dynamic contrast in dual-beam optical coherence tomography imaging of human skin Open
Imaging of metabolic and cellular activity in living tissue is of high interest and represents a prerequisite for an understanding of environmentally induced tissue changes. In this work, we present a dual-beam optical coherence tomography…
View article: Single-nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke in male rodents
Single-nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke in male rodents Open
View article: The Evolution of Transglutaminases Underlies the Origin and Loss of Cornified Skin Appendages in Vertebrates
The Evolution of Transglutaminases Underlies the Origin and Loss of Cornified Skin Appendages in Vertebrates Open
Transglutaminases (TGMs) cross-link proteins by introducing covalent bonds between glutamine and lysine residues. These cross-links are essential for epithelial cornification which enables tetrapods to live on land. Here, we investigated w…
View article: Evolutionary origin of Hoxc13-dependent skin appendages in amphibians
Evolutionary origin of Hoxc13-dependent skin appendages in amphibians Open
Cornified skin appendages, such as hair and nails, are major evolutionary innovations of terrestrial vertebrates. Human hair and nails consist largely of special intermediate filament proteins, known as hair keratins, which are expressed u…
View article: Single nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke
Single nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke Open
Reactive neuroglia critically shape the brain’s response to ischemic stroke. However, their phenotypic heterogeneity impedes a holistic understanding of the cellular composition and microenvironment of the early ischemic lesion. Here we ge…
View article: Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1
Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1 Open
View article: Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C)
Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C) Open
Peripheral contact to pathogen-associated molecular patterns (PAMPs) evokes a systemic innate immune response which is rapidly relayed to the central nervous system (CNS). The remarkable cellular heterogeneity of the CNS poses a significan…
View article: The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring
The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring Open
Hypertrophic scars can cause pain, movement restrictions, and reduction in the quality of life. Despite numerous options to treat hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood.…
View article: Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis
Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis Open
The epidermal barrier of mammals is initially formed during embryonic development and continuously regenerated by the differentiation and cornification of keratinocytes in postnatal life. Cornification is associated with the breakdown of o…
View article: Deletion of <scp>NRF2</scp> disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging
Deletion of <span>NRF2</span> disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging Open
NRF2 is a master regulator of the cellular protection against oxidative damage in mammals and of multiple pathways relevant in the mammalian aging process. In the epidermis of the skin NRF2 contributes additionally to the formation of an a…
View article: Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds
Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds Open
The cross-linking of structural proteins is critical for establishing the mechanical stability of the epithelial compartments of the skin and skin appendages. The introduction of isopeptide bonds between glutamine and lysine residues depen…
View article: Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats
Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats Open
View article: EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary Hypertension
EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary Hypertension Open
Background: Pulmonary hypertension (PH) is a vasoconstrictive disease characterized by elevated mean pulmonary arterial pressure (mPAP) at rest. Idiopathic pulmonary arterial hypertension (iPAH) and chronic thromboembolic pulmonary hyperte…
View article: Schwann cells contribute to keloid formation
Schwann cells contribute to keloid formation Open
Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments. Here we analyzed the characteristics of keloidal cells by single cell sequencing and discovered the …
View article: The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring
The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring Open
View article: Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile
Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile Open
Preputial glands are large lipid and hormone secreting sebaceous organs of mice, and present a convenient model for the investigation of biological processes in sebocytes. Suppression of ATG7-dependent macroautophagy/autophagy in epithelia…
View article: The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation Open
View article: Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile
Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile Open
ATG7: autophagy related 7; BODIPY: boron dipyrromethene; DAG: diacyl glycerides; DBI: diazepam binding inhibitor; GFP: green fluorescent protein; KRT14: keratin 14; HPLC-MS: high performance liquid chromatography-mass spectrometry; LD: lip…
View article: Schwann cells contribute to keloid formation
Schwann cells contribute to keloid formation Open
Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments. Here we analyzed the characteristics of keloidal cells by single cell sequencing and discovered the …
View article: Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile
Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile Open
Preputial glands are large lipid and hormone secreting sebaceous organs of mice, and present a convenient model for the investigation of biological processes in sebocytes. Suppression of ATG7-dependent macroautophagy/autophagy in epithelia…
View article: The secretome of stressed peripheral blood mononuclear cells increases tissue survival in a rodent epigastric flap model
The secretome of stressed peripheral blood mononuclear cells increases tissue survival in a rodent epigastric flap model Open
Reconstructive surgery transfers viable tissue to cover defects and to restore aesthetic and functional properties. Failure rates after free flap surgery range from 3 to 7%. Co‐morbidities such as diabetes mellitus or peripheral vascular d…
View article: Single cell sequencing identifies serine proteases as regulators of myofibroblast differentiation
Single cell sequencing identifies serine proteases as regulators of myofibroblast differentiation Open
Despite recent advances in understanding skin scarring, mechanisms triggering hypertrophic scar formation are still poorly understood. In the present study we performed single-cell sequencing of mature human hypertrophic scars and developi…
View article: Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents – Implications for oxidative UV damage
Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents – Implications for oxidative UV damage Open
View article: Single cell landscape of hypertrophic scars identifies serine proteases as key regulators of myofibroblast differentiation
Single cell landscape of hypertrophic scars identifies serine proteases as key regulators of myofibroblast differentiation Open
Despite recent advances in understanding skin scarring, mechanisms triggering hypertrophic scar formation are still poorly understood. In the present study we performed single-cell sequencing of mature human hypertrophic scars and developi…
View article: Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging
Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging Open
View article: Establishment of keratinocyte cell lines from human hair follicles
Establishment of keratinocyte cell lines from human hair follicles Open
View article: 683 The role of the WFDC [WAP (Whey acidic protein) four-disulfide core] family members in the epidermis
683 The role of the WFDC [WAP (Whey acidic protein) four-disulfide core] family members in the epidermis Open
View article: Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I)
Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I) Open
Developing effective therapies against chronic wound healing deficiencies is a global priority. Thus we evaluated the safety of two different doses of topically administered autologous APOSEC, the secretome of apoptotic peripheral blood mo…