Bahar Rahsepar
YOU?
Author Swipe
View article: Reactivation of memory-associated neurons induces downstream suppression of competing neuronal populations
Reactivation of memory-associated neurons induces downstream suppression of competing neuronal populations Open
Inducing apparent memory recall by tagging and optogenetically reactivating cells in the hippocampus was demonstrated over a decade ago. However, the hippocampal dynamics resulting from this reactivation remain largely unknown. While calci…
View article: 73 Quantifying the effect of microsatellite instability and mismatch repair deficiency on the tumor microenvironment
73 Quantifying the effect of microsatellite instability and mismatch repair deficiency on the tumor microenvironment Open
Background Microsatellite instability (MSI) is an important biomarker for immunotherapy in solid tumors, resulting from deficient mismatch repair (dMMR) and leading to elevated mutational burden. Standard methods for detecting MSI include …
View article: Theta-phase-specific modulation of dentate gyrus memory neurons
Theta-phase-specific modulation of dentate gyrus memory neurons Open
The theta rhythm, a quasi-periodic 4–10 Hz oscillation, is observed during memory processing in the hippocampus, with different phases of theta hypothesized to separate independent streams of information related to the encoding and recall …
View article: Theta phase specific modulation of hippocampal memory neurons
Theta phase specific modulation of hippocampal memory neurons Open
I. Abstract The theta rhythm, a quasi-periodic 4-10 Hz oscillation, is observed during memory processing in the hippocampus, with different phases of theta hypothesized to separate independent streams of information related to the encoding…
View article: Hippocampal cells multiplex positive and negative engrams
Hippocampal cells multiplex positive and negative engrams Open
The hippocampus is involved in processing a variety of mnemonic computations specifically the spatiotemporal components and emotional dimensions of contextual memory. 1–3 Recent studies have demonstrated vast structural and functional hete…
View article: CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy
CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy Open
Single-cell analysis is revealing increasing diversity in gene expression profiles among brain cells. Traditional promotor-based viral gene expression techniques, however, cannot capture the growing variety among single cells. We demonstra…
View article: Differences in the Electrophysiological Properties of Mouse Somatosensory Layer 2/3 Neurons<i>In Vivo</i>and Slice Stem from Intrinsic Sources Rather than a Network-Generated High Conductance State
Differences in the Electrophysiological Properties of Mouse Somatosensory Layer 2/3 Neurons<i>In Vivo</i>and Slice Stem from Intrinsic Sources Rather than a Network-Generated High Conductance State Open
Synaptic activity in vivo can potentially alter the integration properties of neurons. Using recordings in awake mice, we targeted somatosensory layer 2/3 pyramidal neurons and compared neuronal properties with those from slices. Pyramidal…
View article: Anatomical and Electrophysiological Clustering of Superficial Medial Entorhinal Cortex Interneurons
Anatomical and Electrophysiological Clustering of Superficial Medial Entorhinal Cortex Interneurons Open
Local GABAergic interneurons regulate the activity of spatially-modulated principal cells in the medial entorhinal cortex (MEC), mediating stellate-to-stellate connectivity and possibly enabling grid formation via recurrent inhibitory circ…