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View article: Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders
Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders Open
Tic disorders (TD) represent a prevalent neurodevelopmental condition in children, characterised by involuntary, sudden motor or vocal tics. Dysfunction of the dopamine system plays a pivotal role in the pathogenesis of TD. Recent findings…
View article: ROS-Responsive Biomimetic Nanocomplexes of Liposomes and Macrophage-Derived Exosomes for Combination Breast Cancer Therapy
ROS-Responsive Biomimetic Nanocomplexes of Liposomes and Macrophage-Derived Exosomes for Combination Breast Cancer Therapy Open
We have developed a ROS-responsive biomimetic nanocomplexes that efficiently delivers DTX and Bcl-2 siRNA into the tumor site, overcoming the MPS barrier and extending the blood circulation time of the drug. Hence, biomimetic nanocomplex i…
View article: Clinical Phenotype and Genetic Analysis of a Family with Hereditary Antithrombin Deficiency Caused by SERPINC1 Gene Mutation
Clinical Phenotype and Genetic Analysis of a Family with Hereditary Antithrombin Deficiency Caused by SERPINC1 Gene Mutation Open
Inherited deficiency of the antithrombin (hereditary antithrombin deficiency, AT deficiency, OMIM #613118) is a relatively rare (1:2,000–3,000) autosomal-dominant disorder with high risk of venous thromboembolism. The molecular basis of th…
View article: Possible antidepressant mechanism of acupuncture: targeting neuroplasticity
Possible antidepressant mechanism of acupuncture: targeting neuroplasticity Open
Major depressive disorder (MDD) is a highly prevalent and severely disabling psychiatric disorder that decreases quality of life and imposes substantial economic burden. Acupuncture has emerged as an effective adjunctive treatment for depr…
View article: The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy
The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy Open
Antibody-drug conjugates (ADCs) offer targeted cancer therapy by delivering cytotoxic agents directly to tumor cells. However, challenges such as relapse, resistance, and diverse patient needs drive ongoing innovation in ADC development. E…
View article: Native nucleosome-positioning elements for the investigation of nucleosome repositioning
Native nucleosome-positioning elements for the investigation of nucleosome repositioning Open
Nucleosome repositioning is essential for establishing nucleosome-depleted regions (NDRs) to initiate transcription. This process has been extensively studied using structural, biochemical, and single-molecule approaches, which require hom…
View article: Adaptive spatiotemporal encoding network for cognitive assessment using resting state EEG
Adaptive spatiotemporal encoding network for cognitive assessment using resting state EEG Open
Cognitive impairment, marked by neurodegenerative damage, leads to diminished cognitive function decline. Accurate cognitive assessment is crucial for early detection and progress evaluation, yet current methods in clinical practice lack o…
View article: Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory
Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory Open
View article: Precise prediction of cerebrospinal fluid amyloid beta protein for early Alzheimer's disease detection using multimodal data
Precise prediction of cerebrospinal fluid amyloid beta protein for early Alzheimer's disease detection using multimodal data Open
Alzheimer's disease (AD) constitutes a neurodegenerative disorder marked by a progressive decline in cognitive function and memory capacity. The accurate diagnosis of this condition predominantly relies on cerebrospinal fluid (CSF) markers…
View article: APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease
APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease Open
View article: An ensemble learning model for continuous cognition assessment based on resting-state EEG
An ensemble learning model for continuous cognition assessment based on resting-state EEG Open
View article: Investigation of Pulsed Magnetic Field Treatment to Enhance the Properties of Pcb Micro Drill
Investigation of Pulsed Magnetic Field Treatment to Enhance the Properties of Pcb Micro Drill Open
View article: A Cross-Device Ensemble Learning Model for Continuous Cognition Assessment Based on Resting-State EEG
A Cross-Device Ensemble Learning Model for Continuous Cognition Assessment Based on Resting-State EEG Open
One critical manifestation of neurological deterioration is the sign of cognitive decline. Causes of cognitive decline include but are not limited to: aging, cerebrovascular disease, Alzheimer's disease, and trauma. Currently, the primary …
View article: A protocol for establishing a male G×E schizophrenia mouse model
A protocol for establishing a male G×E schizophrenia mouse model Open
View article: Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress
Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress Open
While schizophrenia pathogenesis involves both genetic and environmental factors, their specific combinations remain ill-defined. Here we show that deficiency in promoter VI-driven BDNF expression, combined with early-life adversity, resul…
View article: Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy
Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy Open
View article: Additional file 4 of Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses
Additional file 4 of Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses Open
Additional file 4. The peak areas of all the lipid molecules identified in the liver of control and affected groups.
View article: Additional file 1 of Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses
Additional file 1 of Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses Open
Additional file 1. The peak areas of all the lipid molecules identified in the breast of control and affected groups.
View article: An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments
An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments Open
A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy. Transgenic mice overexpressing amyloid precursor protein ( App ) gene manife…
View article: Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention Open
View article: Graphical Abstract: Angew. Chem. Int. Ed. 9/2021
Graphical Abstract: Angew. Chem. Int. Ed. 9/2021 Open
Ad ynamic library including an Fe II 4 L 6 irregular structure and three Fe II 2 L 3 stereoisomers was formed by subcomponent self-assembly.Glucose amplifies the formation of the (P)-Fe II 2 L 3 helicate, which in turn amplifies b-D-glucos…
View article: Astrocytic Microdomains Confine A “molecular Memory” Enabling Long-Term Information Storage for Memory Consolidation
Astrocytic Microdomains Confine A “molecular Memory” Enabling Long-Term Information Storage for Memory Consolidation Open
Memory consolidation requires astrocytic microdomains for protein recycling; but whether this lays a mechanistic foundation for long-term information storage remains enigmatic. Here we demonstrate that persistent synaptic strengthening inv…
View article: Clone, expression and plasminogen binding property of three fructose-1,6-bisphosphate aldolases from Clonorchis sinensis
Clone, expression and plasminogen binding property of three fructose-1,6-bisphosphate aldolases from Clonorchis sinensis Open
Fructose-1,6-bisphosphate aldolase (FbA), a well characterized glycometabolism enzyme, has been found to participate in other important processes besides the classic catalysis. To understand the important functions of three fructose-1,6-bi…
View article: Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway
Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway Open
The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the CaMK pathway improves depression-like behavior and the molecular mechanism related to its antidepre…
View article: Interaction Between BDNF Val66Met and APOE4 on Biomarkers of Alzheimer’s Disease and Cognitive Decline
Interaction Between BDNF Val66Met and APOE4 on Biomarkers of Alzheimer’s Disease and Cognitive Decline Open
Background: Whether brain-derived neurotrophic factor (BDNF) Met carriage impacts the risk or progression of Alzheimer’s disease (AD) is unknown. Objective: To evaluate the interaction of BDNF Met and APOE4 carriage on cerebral metabolic r…
View article: Engineering a Magnetic Protein Crystal
Engineering a Magnetic Protein Crystal Open
View article: Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease
Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease Open
Repeated failures of "Aβ-lowering" therapies call for new targets and therapeutic approaches for Alzheimer's disease (AD). We propose to treat AD by halting neuronal death and repairing synapses using a BDNF-based therapy. To overcome the …
View article: Corrigendum: BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors
Corrigendum: BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors Open
[This corrects the article on p. 306 in vol. 11, PMID: 29075179.].
View article: MagR Alone Is Insufficient to Confer Cellular Calcium Responses to Magnetic Stimulation
MagR Alone Is Insufficient to Confer Cellular Calcium Responses to Magnetic Stimulation Open
Magnetic manipulation of cell activity offers advantages over optical manipulation but an ideal tool remains elusive. The MagR protein was found through its interaction with cryptochrome (Cry) and the protein in solution appeared to respon…
View article: Issue Information
Issue Information Open
Brain and Behavior is a peer-reviewed, interdisciplinary journal