Baihua Chen
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View article: Ferroptosis and organelle roles in dry eye
Ferroptosis and organelle roles in dry eye Open
View article: DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN.
DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN. Open
DJ-1 deficiency disrupts mitochondrial function, upregulates PTEN, and suppresses antioxidant protein expression, exacerbating corneal oxidative stress. These findings provide insights into molecular mechanisms underlying DK.
View article: Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study
Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study Open
View article: ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye (Adv. Sci. 16/2025)
ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye (Adv. Sci. 16/2025) Open
Microneedle Patches for Dry Eye Treatment
View article: ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye
ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye Open
Sjögren's syndrome‐related dry eye (SSDE) is a severe dry eye subtype characterized by significant immune cell attacks on the lacrimal gland. However, delivering immunosuppressive drugs to the lacrimal glands for SSDE therapy safely and su…
View article: Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy
Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy Open
The production of inflammatory factors in the eyes of individuals with high myopia and pathological myopia was altered, and the elevated levels of intraocular pro-inflammatory factors such as Chi3l1, IL-6Rα, and IL-8 were closely associate…
View article: DJ-1 regulates mitochondrial function and promotes retinal ganglion cell survival under high glucose-induced oxidative stress
DJ-1 regulates mitochondrial function and promotes retinal ganglion cell survival under high glucose-induced oxidative stress Open
Purpose This study aimed to investigate the antioxidative and neuroprotective effects of DJ-1 in mitigating retinal ganglion cell (RGC) damage induced by high glucose (HG). Methods A diabetic mouse model and an HG-induced R28 cell model we…
View article: Research progress of nano delivery systems for intraocular pressure lowering drugs
Research progress of nano delivery systems for intraocular pressure lowering drugs Open
View article: Effective Optical Zone Diameter, Decentration and High-Order Aberrations Following LIKE in Correcting Moderate to High Hyperopia
Effective Optical Zone Diameter, Decentration and High-Order Aberrations Following LIKE in Correcting Moderate to High Hyperopia Open
Background To compare the changes in effective optical zone (EOZ), centration offset and higher-order aberrations between femtosecond laser–assisted lenticule intrastromal keratoplasty (LIKE) and femtosecond-assisted laser in-situ keratomi…
View article: Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis
Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis Open
View article: Construction of miRNA-mRNA regulatory network indicates potential biomarkers for primary open-angle glaucoma
Construction of miRNA-mRNA regulatory network indicates potential biomarkers for primary open-angle glaucoma Open
View article: Thermodynamics of Thorium(IV) complexes with N-methylethylenediamine-N,Nʹ,Nʹ-triacetate in aqueous solutions: Potentiometry and microcalorimetry
Thermodynamics of Thorium(IV) complexes with N-methylethylenediamine-N,Nʹ,Nʹ-triacetate in aqueous solutions: Potentiometry and microcalorimetry Open
The thermodynamic parameters of the complexes of Th with N-methylethylenediamine-N,Nʹ,Nʹ-triacetic acid (MEDTA; denoted as H3L with three dissociable protons) were studied. Potentiometry and microcalorimetry were used to determine formatio…
View article: A comparative study of adsorption properties of zirconium (IV) phosphonates for removal of 90Sr
A comparative study of adsorption properties of zirconium (IV) phosphonates for removal of 90Sr Open
With as goal of improving on traditional α-ZrP, four zirconium phosphonate materials were prepared as potential adsorbents for the removal of 90Sr from nuclear wastewater. A typical sol–gel method was used, for phosphonates: hydroxy ethyli…
View article: 3% diquafosol sodium eye drops in Chinese patients with dry eye: a phase IV study
3% diquafosol sodium eye drops in Chinese patients with dry eye: a phase IV study Open
Introduction The efficacy and safety of 3% diquafosol sodium eye drops in Chinese patients with dry eye in the real-world setting remains unclear. Methods 3099 patients with dry eye symptoms were screened according to Asia Dry Eye Society …
View article: Rapamycin antagonizes angiogenesis and lymphangiogenesis through myeloid-derived suppressor cells in corneal transplantation
Rapamycin antagonizes angiogenesis and lymphangiogenesis through myeloid-derived suppressor cells in corneal transplantation Open
View article: Evaluation and correlation analysis of ocular surface disorders and quality of life in autoimmune rheumatic diseases: a cross-sectional study
Evaluation and correlation analysis of ocular surface disorders and quality of life in autoimmune rheumatic diseases: a cross-sectional study Open
View article: Autophagy and senescence of rat retinal precursor cells under high glucose
Autophagy and senescence of rat retinal precursor cells under high glucose Open
Backgrounds Diabetic retinopathy (DR) is a common diabetic ocular disease characterized by retinal ganglion cell (RGC) changes. An abnormal environment, hyperglycemia, may progressively alter the structure and function of RGCs, which is a …
View article: Complexes of bipyridinecarboxylate and phenanthrolinecarboxylate with trivalent actinides and lanthanides: Binding strength and structure
Complexes of bipyridinecarboxylate and phenanthrolinecarboxylate with trivalent actinides and lanthanides: Binding strength and structure Open
The binding strengths of ligand 2,2ʹ-bipyridine-6-carboxylate (BiPCA) and 1,10-phenanthroline-2-carboxylate (PhenCA) with trivalent actinides (An) like Am(III) and Cm(III), and lanthanides (Ln) like Nd(III), Sm(III), and Eu(III) were inves…
View article: Thermodynamics on the complexation of uranium (VI) with N-methylethylenediamine-N,N′,N'-triacetic acid in aqueous Solution: Potentiometry and microcalorimetry
Thermodynamics on the complexation of uranium (VI) with N-methylethylenediamine-N,N′,N'-triacetic acid in aqueous Solution: Potentiometry and microcalorimetry Open
Stability constants and enthalpies of N-methylethylenediamine-N,N′,N'-triacetic acid (MEDTA, denoted as H3L) complexes with uranyl were measured using potentiometry and microcalorimetry, I = 1.0 mol L−1 NaClO4 solution at 25 °C. Thermodyna…
View article: Effects of Tafluprost on Ocular Blood Flow
Effects of Tafluprost on Ocular Blood Flow Open
Increasing evidence indicates that improving ocular blood flow (OBF) can be a therapeutic direction for glaucoma therapy. Tafluprost, a prostaglandin analogue which lowers the intraocular pressure (IOP), has been shown to improve OBF in an…
View article: IL-22/IL-22RA1 promotes human Tenon’s capsule fibroblasts proliferation and regulates fibrosis through STAT3 signaling pathway
IL-22/IL-22RA1 promotes human Tenon’s capsule fibroblasts proliferation and regulates fibrosis through STAT3 signaling pathway Open
The study is aimed to investigate that the IL-22/IL-22RA1 signaling pathway regulates scar formation. A total of 31 glaucoma patients who had been previously treated with trabeculectomy surgery and the intraocular pressure was uncontrollab…
View article: Research Progress and Potential Applications of Spermidine in Ocular Diseases
Research Progress and Potential Applications of Spermidine in Ocular Diseases Open
Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell proliferation activation, and ion channel regulation. Considerin…
View article: Complexation of uranyl with chelidamic acid: Crystal structures, binding strength, and electrochemical redoxes
Complexation of uranyl with chelidamic acid: Crystal structures, binding strength, and electrochemical redoxes Open
Chelidamic acid (denoted as H3L in this paper) is a naturally occurring derivative of dipicolinic acid that functions as a versatile ligand. The complex formation of chelidamic acid with UO22+ has been investigated by potentiometry in a 0.…
View article: Protective activity of tert-butylhydroquinone against oxidative stress and apoptosis induced by glutamate agonizts in R28 cells and mice retina
Protective activity of tert-butylhydroquinone against oxidative stress and apoptosis induced by glutamate agonizts in R28 cells and mice retina Open
Glutamate excitotoxicity can cause cell damage and apoptosis and play an important role in a variety of retinal diseases. Tertiary-butylhydroquinone (tBHQ) is an approved food-grade phenolic antioxidant with antioxidant activity in a varie…
View article: The Association Between Consumption of 100% Fruit Juice and Risk of Age-Related Macular Degeneration: Data From the National Health and Nutrition Examination Survey Database
The Association Between Consumption of 100% Fruit Juice and Risk of Age-Related Macular Degeneration: Data From the National Health and Nutrition Examination Survey Database Open
Age-related macular degeneration (AMD) is the main irreversible blindness disease worldwide. The current study aimed to investigate whether the consumption of 100% fruit juice increases the risk of age-related macular degeneration and find…
View article: Evaluation of the Ocular Surface and Meibomian Gland in Obstructive Sleep Apnea Hypopnea Syndrome
Evaluation of the Ocular Surface and Meibomian Gland in Obstructive Sleep Apnea Hypopnea Syndrome Open
Purpose To assess the ocular surface and meibomian gland (MG) of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and to explore the effects of surgery for OSAHS on the ocular surface and MG. Methods Based on the apnea hypop…
View article: Evaluation of optical quality in pterygium patients with a new modified sutureless and glue-free method
Evaluation of optical quality in pterygium patients with a new modified sutureless and glue-free method Open
View article: Identification and validation of hub genes for diabetic retinopathy
Identification and validation of hub genes for diabetic retinopathy Open
Background Diabetic retinopathy (DR) is characterized by a gradually progressive alteration in the retinal microvasculature that leads to middle-aged adult acquired persistent blindness. Limited research has been conducted on DR pathogenes…
View article: Intraorbital Mercury Removal by DSA Positioning and Route Marking: A 4-year Follow-up
Intraorbital Mercury Removal by DSA Positioning and Route Marking: A 4-year Follow-up Open
Background: Mercury is a widely used heavy metal. Traumatic mercury residue often leads to contact dermatitis, granuloma, even chronic poisoning. Due to its unique physical and chemical properties, mercury beads can be difficult to retriev…
View article: Overcoming Structural Collapse in Stable Zirconium Phosphonate Materials for Strontium Removal
Overcoming Structural Collapse in Stable Zirconium Phosphonate Materials for Strontium Removal Open