Bailey D. Peck
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View article: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise
Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise Open
Extracellular vesicles (EVs) have emerged as important mediators of intertissue signaling and exercise adaptations. In this human study, we provide evidence that muscle-specific microRNA-1 (miR-1) was transferred to adipose tissue via EVs …
View article: microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism
microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism Open
MicroRNA-1 (miR-1) is the most abundant miRNA in adult skeletal muscle. To determine the function of miR-1 in adult skeletal muscle, we generated an inducible, skeletal muscle-specific miR-1 knockout (KO) mouse. Integration of RNA-sequenci…
View article: Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons
Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons Open
Extensive analyses of muscle features associated with muscle size and resistance training response in older persons, including sex differences, and evaluation of multiple measures of hypertrophy are discussed. New skeletal muscle features,…
View article: Mechanotherapy Reprograms Aged Muscle Stromal Cells to Remodel the Extracellular Matrix during Recovery from Disuse
Mechanotherapy Reprograms Aged Muscle Stromal Cells to Remodel the Extracellular Matrix during Recovery from Disuse Open
Aging is accompanied by reduced remodeling of skeletal muscle extracellular matrix (ECM), which is exacerbated during recovery following periods of disuse atrophy. Mechanotherapy has been shown to promote ECM remodeling through immunomodul…
View article: Myonuclear transcriptional dynamics in response to exercise following satellite cell depletion
Myonuclear transcriptional dynamics in response to exercise following satellite cell depletion Open
Skeletal muscle is composed of post-mitotic myofibers that form a syncytium containing hundreds of myonuclei. Using a progressive exercise training model in the mouse and single nucleus RNA-sequencing (snRNA-seq) for high-resolution charac…
View article: Mechanical overload‐induced muscle‐derived extracellular vesicles promote adipose tissue lipolysis
Mechanical overload‐induced muscle‐derived extracellular vesicles promote adipose tissue lipolysis Open
How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mec…
View article: Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneity
Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneity Open
The skeletal muscle hypertrophic response to resistance exercise training (RT) is highly variable across individuals. The molecular underpinnings of this heterogeneity are unclear. This study investigated transcriptional networks linked to…
View article: TRANSCRIPTOMIC AND CELLULAR RESPONSE TO MECHANICAL OVERLOAD AND THE UNDERLYING ROLE OF MACROPHAGES IN EXTRACELLULAR MATRIX REMODELING
TRANSCRIPTOMIC AND CELLULAR RESPONSE TO MECHANICAL OVERLOAD AND THE UNDERLYING ROLE OF MACROPHAGES IN EXTRACELLULAR MATRIX REMODELING Open
The extracellular matrix (ECM) in skeletal muscle plays an integral role in tissue development, structural support, and force transmission. Upon mechanical loading, including resistance exercise, which alter muscle fiber contractile activi…
View article: Satellite Cell Depletion Disrupts Transcriptional Coordination and Muscle Adaptation to Exercise
Satellite Cell Depletion Disrupts Transcriptional Coordination and Muscle Adaptation to Exercise Open
Satellite cells are required for postnatal development, skeletal muscle regeneration across the lifespan, and skeletal muscle hypertrophy prior to maturity. Our group has aimed to address whether satellite cells are required for hypertroph…
View article: Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults
Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults Open
Evidence from clinical trials and observational studies suggests that both progressive resistance exercise training (PRT) and metformin delay a variety of age-related morbidities. Previously, we completed a clinical trial testing the effec…
View article: In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans
In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans Open
Over the past 20 years, various identifiers of cellular senescence have been used to quantify the abundance of these cells in different tissues. These include classic markers such as p16, senescence‐associated β‐gal, and γH2AX, in addition…
View article: Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial
Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial Open
Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation suscepti…
View article: Resident muscle stem cells are not required for testosterone-induced skeletal muscle hypertrophy
Resident muscle stem cells are not required for testosterone-induced skeletal muscle hypertrophy Open
It is postulated that testosterone-induced skeletal muscle hypertrophy is driven by myonuclear accretion as the result of satellite cell fusion. To directly test this hypothesis, we utilized the Pax7-DTA mouse model to deplete satellite ce…
View article: Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality
Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality Open
Background: Anterior cruciate ligament (ACL) tears result in significant quadriceps muscle atrophy that is resistant to recovery despite extensive rehabilitation. Recent work suggests an elevated fibrotic burden in the quadriceps muscle af…
View article: Immunohistochemical Identification of Human Skeletal Muscle Macrophages
Immunohistochemical Identification of Human Skeletal Muscle Macrophages Open
Macrophages have well-characterized roles in skeletal muscle repair and regeneration. Relatively little is known regarding the role of resident macrophages in skeletal muscle homeostasis, extracellular matrix remodeling, growth, metabolism…
View article: Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle
Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle Open
Protein kinase C-θ (PKC-θ) is a lipid-sensitive molecule associated with lipid-induced insulin resistance in skeletal muscle. Rodent models have not cohesively supported that PKC-θ impairs insulin responsiveness in skeletal muscle. The pur…
View article: Overexpression of Glucocorticoid Receptor β Enhances Myogenesis and Reduces Catabolic Gene Expression
Overexpression of Glucocorticoid Receptor β Enhances Myogenesis and Reduces Catabolic Gene Expression Open
Unlike the glucocorticoid receptor α (GRα), GR β (GRβ) has a truncated ligand-binding domain that prevents glucocorticoid binding, implicating GRα as the mediator of glucocorticoid-induced skeletal muscle loss. Because GRβ causes glucocort…