Explanipedia

The Open Pediatric Cancer Project Open

Zhuangzhuang Geng, Eric Wafula, Ryan J. Corbett, Yuanchao Zhang, Run Jin , et al. · 2025

Background In 2019, the Open Pediatric Brain Tumor Atlas (OpenPBTA) was created as a global, collaborative open-science initiative to genomically characterize 1,074 pediatric brain tumors and 22 patient-derived cell lines. Here, we present…

The Open Pediatric Cancer Project Open

Zhuangzhuang Geng, Eric Wafula, Ryan J. Corbett, Yuanchao Zhang, Run Jin , et al. · 2024

Background In 2019, the Open Pediatric Brain Tumor Atlas (OpenPBTA) was created as a global, collaborative open-science initiative to genomically characterize 1,074 pediatric brain tumors and 22 patient-derived cell lines. Here, we present…

METB-11. EXPANSION OF THE PEDIATRIC BRAIN TUMOR ATLAS: AN OPEN SCIENCE EFFORT OF CHILDREN’S BRAIN TUMOR NETWORK, KIDS FIRST DATA RESOURCE AND CHILDHOOD CANCER DATA INITIATIVE Open

Mateusz Koptyra, Bailey Farrow, Catherine Sullivan, Noel Coleman, Komal S. Rathi , et al. · 2023

Pediatric central nervous system cancers are the leading disease-related cause of death in children and there is urgent need for curative therapeutic strategies for these tumors. To address the urgency, Children’s Brain Tumor Network (CBTN…

OpenPBTA: The Open Pediatric Brain Tumor Atlas Open

Joshua A. Shapiro, Krutika S. Gaonkar, Stephanie J. Spielman, Candace Savonen, Chanté J. Bethell , et al. · 2023

Data underlying OpenPBTA Manuscript Figures and Molecular Alterations Open

Joshua A. Shapiro, Krutika S. Gaonkar, Stephanie J. Spielman, Candace Savonen, Chanté J. Bethell , et al. · 2023

This upload contains CSV files that represent data contained in plots shown in the OpenPBTA manuscript. It is intended to facilitate inspection of the underlying data shown in each figure and to explicitly capture which samples are include…

Data underlying OpenPBTA Manuscript Figures and Molecular Alterations Open

Joshua A. Shapiro, Krutika S. Gaonkar, Stephanie J. Spielman, Candace Savonen, Chanté J. Bethell , et al. · 2023

This upload contains CSV files that represent data contained in plots shown in the OpenPBTA manuscript. It is intended to facilitate inspection of the underlying data shown in each figure and to explicitly capture which samples are include…

Data underlying OpenPBTA Manuscript Figures and Molecular Alterations Open

Joshua A. Shapiro, Krutika S. Gaonkar, Stephanie J. Spielman, Candace Savonen, Chanté J. Bethell , et al. · 2023

This upload contains CSV files that represent data contained in plots shown in the OpenPBTA manuscript. It is intended to facilitate inspection of the underlying data shown in each figure and to explicitly capture which samples are include…

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science Open

Jena Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz , et al. · 2022

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer…

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science Open

Jena Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz , et al. · 2022

The Children’s Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open Science Open

Jena Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz , et al. · 2022

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer…

OpenPBTA: An Open Pediatric Brain Tumor Atlas Open

Joshua A. Shapiro, Krutika S. Gaonkar, Candace Savonen, Stephanie J. Spielman, Chanté J. Bethell , et al. · 2022

Summary Pediatric brain and spinal cancer are the leading disease-related cause of death in children, thus we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, the Children’s Brain Tumor Networ…

OTHR-45. Kids First Variant WorkBench: application to germline genomic discoveries in the Children's Brain Tumor Network Open

Yiran Guo, Jeremy Costanza, Christophe Botek, Miguel Brown, David Higgins , et al. · 2022

The Gabriella Miller Kids First Pediatric Research Program (Kids First) aims at facilitating researchers to uncover new insights into the biology of childhood cancer (CC) and structural birth defects (SBD). Kids First has two initiatives, …

OMIC-14. OPENPBTA: AN OPEN PEDIATRIC BRAIN TUMOR ATLAS Open

Joshua A. Shapiro, Candace Savonen, Chanté J. Bethell, Krutika S. Gaonkar, Yuankun Zhu , et al. · 2021

Pediatric brain tumors comprise a heterogeneous molecular and histological landscape that challenges most current precision-medicine approaches. While recent large-scale efforts to molecularly characterize distinct histological entities ha…

EPID-14. GABRIELLA MILLER KIDS FIRST DATA RESOURCE CENTER: COLLABORATIVE PLATFORMS FOR ACCELERATING RESEARCH IN PEDIATRIC CANCERS & STRUCTURAL BIRTH DEFECTS Open

Allison P. Heath, Yuankun Zhu, Michele Mattioni, Bailey Farrow, Jena Lilly , et al. · 2020

Since launching to the public in September 2018, the Gabriella Miller Kids First Data Resource Center (DRC) has made an increasing number of pediatric genomic studies available to the research community. Currently, 1.3 PBs of genomic and c…

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer Open

Francesca Petralia, Nicole Tignor, Boris Reva, Mateusz Koptyra, Shrabanti Chowdhury , et al. · 2020

Translational Personas and Hospital Library Services Open

Sara Gonzales, Lisa Lea O'Keefe, Karen E Gutzman, Guillaume Viger, Annie Wescott , et al. · 2020

Academic health centers, CTSA hubs, and hospital libraries experience similar funding challenges and charges to do more with less. In recent years academic health center and hospital librarians have risen to these challenges by exam…

Personas for the translational workforce Open

Sara Gonzales, Lisa Lea O'Keefe, Karen E Gutzman, Guillaume Viger, Annie Wescott , et al. · 2020

Twelve evidence-based profiles of roles across the translational workforce and two patients were made available through clinical and translational science (CTS) Personas, a project of the Clinical and Translational Science Awards (CTSA) Pr…

Abstract 3667: The Pediatric Brain Tumor Atlas - Transforming the landscape of research Open

Yuankun Zhu, Yiran Guo, Allison P. Heath, Pichai Raman, Elizabeth Appert , et al. · 2019

The Pediatric Brain Tumor Atlas (PBTA) is a cloud-based, cross-platform, and data-rich collaborative effort to accelerate discoveries for therapeutic intervention in children diagnosed with brain tumors. Pediatric brain tumors are the lead…

TMOD-20. THE PEDIATRIC BRAIN TUMOR ATLAS: AN INITIATIVE BY THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM AND PACIFIC PEDIATRIC NEUROONCOLOGY CONSORTIUM Open

Yuankun Zhu, Yiran Guo, Allison P. Heath, Pichai Raman, Elizabeth Appert , et al. · 2019

The Pediatric Brain Tumor Atlas (PBTA), created as a multi-center effort by the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pacific Pediatric Neuro-Oncology Consortium (PNOC) and supported by the Gabriella Miller Kids First Data R…

Clinical research coordinator persona profile Open