Bailey Rawlinson
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View article: Socioeconomic deprivation and medical comorbidity burden associations with clinicopathologic characteristics in an ethnoracially diverse Alzheimer's disease autopsy series
Socioeconomic deprivation and medical comorbidity burden associations with clinicopathologic characteristics in an ethnoracially diverse Alzheimer's disease autopsy series Open
Background Population aging is expected to increase the burden of Alzheimer's disease (AD) and related dementias (ADRD), yet up to 45% of ADRD risk may be modified. Disparities in ADRD burden among Hispanic/Latino and Black/African America…
View article: <scp>TDP‐43</scp> Cryptic <scp>RNAs</scp> in Perry Syndrome: Differences across Brain Regions and <scp>TDP‐43</scp> Proteinopathies
<span>TDP‐43</span> Cryptic <span>RNAs</span> in Perry Syndrome: Differences across Brain Regions and <span>TDP‐43</span> Proteinopathies Open
Background Perry syndrome (PS) is a rare and fatal hereditary autosomal dominant neurodegenerative disorder caused by mutations in dynactin ( DCTN1 ). PS brains accumulate inclusions positive for ubiquitin, transactive‐response DNA‐binding…
View article: Identification of regional and cell type‐specific gene dysregulation in Progressive Supranuclear Palsy
Identification of regional and cell type‐specific gene dysregulation in Progressive Supranuclear Palsy Open
Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder involving pathological deposition of tau that includes glial inclusions and specific regional vulnerability patterns. Therapeutic developments are hampered by …
View article: The UFMylation pathway is impaired in Alzheimer’s disease
The UFMylation pathway is impaired in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is characterized by the presence of neurofibrillary tangles made of hyperphosphorylated tau and senile plaques composed of beta-amyloid. These pathognomonic deposits have been implicated in the pathogene…
View article: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases Open
This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
View article: TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia Open
Genetic variation at the transmembrane protein 106B gene ( TMEM106B) has been linked to risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an unknown mechanism. We found that presence of the TMEM106B rs3173…
View article: Utilizing fNIRS to measure cognitive control and explore its relationship to racial bias reduction
Utilizing fNIRS to measure cognitive control and explore its relationship to racial bias reduction Open
Honorable Mention Winner:\nThis research investigated the relationship between cognitive control and a stereotype-reduction training task. The sample pool of participants consisted mainly of Caucasian female students attending the Universi…