Baisen Chen
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View article: Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer
Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer Open
Excess cholesterol is positively correlated with colorectal cancer (CRC). Current therapeutic strategies for modulating cholesterol levels in CRC are limited and often come with complications. Here, we demonstrated that microbiome shunting…
View article: Dihydro-Resveratrol Attenuates Oxidative Stress, Adipogenesis and Insulin Resistance in In Vitro Models and High-Fat Diet-Induced Mouse Model via AMPK Activation
Dihydro-Resveratrol Attenuates Oxidative Stress, Adipogenesis and Insulin Resistance in In Vitro Models and High-Fat Diet-Induced Mouse Model via AMPK Activation Open
Management of obesity has become a prevalent strategy for preventing the diseases closely integrated with excess body weight such as diabetes over the last half century. Searching for therapeutic agents acting on oxidative stress, adipogen…
View article: Omics approach to reveal the effects of obesity on the protein profiles of the exosomes derived from different adipose depots
Omics approach to reveal the effects of obesity on the protein profiles of the exosomes derived from different adipose depots Open
Background: Obesity affects the cargo packaging of the adipocyte-derived exosomes. Furthermore, adipocytes in different adipose tissues have different genetic makeup, the cargo contents of the exosomes derived from different adipose tissue…
View article: Baicalein is a novel TLR4‐targeting therapeutics agent that inhibits TLR4/HIF‐1α/VEGF signaling pathway in colorectal cancer
Baicalein is a novel TLR4‐targeting therapeutics agent that inhibits TLR4/HIF‐1α/VEGF signaling pathway in colorectal cancer Open
Toll-like receptor 4(TLR4) is a rational therapeutic target. We have discovered that baicalein directly binds to TLR4, which is a strategy to inhibit TLR4 activity. In our study, molecular docking showed that baicalein directly bound to TL…
View article: Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis
Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis Open
Hepatocellular carcinoma (HCC) is difficult to treat, and is the second leading cause of cancer-related death worldwide. This study aimed to examine whether combination of wogonin and artesunate exhibits synergistic anti-HCC effect. Our da…
View article: The advantages of using Scutellaria baicalensis and its flavonoids for the management of non-viral hepatocellular carcinoma
The advantages of using Scutellaria baicalensis and its flavonoids for the management of non-viral hepatocellular carcinoma Open
Scutellaria baicalensis Georgi is functional food and potential therapeutics for liver cancer. Among all the primary liver cancer, hepatocellular carcinoma (HCC) is the most common sub-type. The non-viral causes of HCC include diabetes mel…
View article: The therapeutic potential of Scutellaria baicalensis for the treatment of obesity-driven hepatocellular carcinoma
The therapeutic potential of Scutellaria baicalensis for the treatment of obesity-driven hepatocellular carcinoma Open
Obesity is closely associated with non-alcoholic fatty liver disease which will develop into hepatocellular carcinoma (HCC). Obesity per se is also an independent risk factor for HCC. Lipotoxicity, adipose tissue remodeling, modulation of …