Explanipedia

Sustainable Nanoparticle Synthesis Using <i>Tinospora cordifolia</i> (Giloy) Leaves Extracts: Evaluation of Antimicrobial Efficacy Against MultiDrug Resistant Bacteria and Optical Features Open

Jyoti Jaglan, Anshu Jaglan, Brij B. Singh, Harsh Jaglan, Preeti Jaglan , et al. · 2025

Sustainable synthesis, also known as environmentally benign synthesis, of nanoparticles, presents an energy and resource-efficient approach for the development of nanoparticles to advanced materials with considerable biomedical potential. …

Author Correction: Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype Open

Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge J. De La Chapa, R. Karthik , et al. · 2025

Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype Open

Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge A. González-Chapa, R. Karthik , et al. · 2025

Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. Our findings reveal that Mg²⁺ entry through distinct …

The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury Open

Hak Joo Lee, Yuyang Sun, Falguni Das, Wenjun Ju, Viji Nair , et al. · 2025

The role played by anionic channels in diabetic kidney disease (DKD) is not known. Chloride channel accessory 1 (CLCA1) facilitates the activity of TMEM16A (Anoctamin-1), a Ca2+-dependent Cl- channel. We examined if CLCA1/TMEM16A had a rol…

Single-cell spatial transcriptomics delineates the presence and function of intratumoral bacterial signals in acral melanoma patients treated with immunotherapy Open

Florentia Dimitriou, Bárbara Meléndez, Lon W. Fong, P. Nagarajan, Brij B. Singh , et al. · 2025

Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis Open

Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Gopalam Rahul, Xue Yang , et al. · 2024

Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence. The precise…

Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models Open

Viviane Nascimento Da Conceicao, Yuyang Sun, Xiufang Chai, Julian L. Ambrus, Bibhuti B. Mishra , et al. · 2023

Ablation of TRPC3 disrupts Ca2+ signaling in salivary ductal cells and promotes sialolithiasis Open

B I Choi, Samuel Shin, Sade Evans, Brij B. Singh, Bidhan C. Bandyopadhyay · 2023

Clinical studies and structural analyses of salivary stones strongly suggest a linkage between higher saliva calcium (Ca 2+ ) and salivary stone formation, sialolithiasis ; however, the process and the mechanism leading to Ca 2+ overload d…

Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca<sup>2+</sup> signalling Open

Yuyang Sun, Viviane Nascimento Da Conceicao, Arun Chauhan, Pramod Sukumaran, Pooja Chauhan , et al. · 2023

Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown. The aim of this study was to underst…

Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress Open

Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu , et al. · 2023

The most abundant cellular divalent cations, Mg²⁺ (mM) and Ca²⁺ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of magnitude affinity preference, but the physiological significance …

R(h)oad to antitumour therapy Open

Viviane Nascimento Da Conceicao, Bibhuti B. Mishra, Brij B. Singh · 2022

Autophagy, an evolutionarily intracellular degradation catabolic process maintains cellular homeostasis during stress conditions to recycle nutrients from damaged organelles.1, 2 Importantly, although autophagy plays a dual role in tumour …

Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR) Open

Kate Larson, Brij B. Singh, Amy Bundy, Dale Brunelle, Michael R. Bukowski , et al. · 2022

Inhibition of Ca2+ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation Open

Yuyang Sun, Emily K. Zboril, Jorge J. De La Chapa, Xiufang Chai, Viviane Nascimento Da Conceicao , et al. · 2022

Oral cancer patients have a poor prognosis, with approximately 66% of patients surviving 5-years after diagnosis. Treatments for oral cancer are limited and have many adverse side effects; thus, further studies are needed to develop drugs …

Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo Open

Olivia N. Tran, Hanzhou Wang, Shengxian Li, А. Yu. Malakhov, Yuyang Sun , et al. · 2022

Corrigendum: Lipidomic Analysis of TRPC1 Ca2+-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet Open

Michael R. Bukowski, Brij B. Singh, James N. Roemmich, Kate Larson · 2022

[This corrects the article DOI: 10.3389/fendo.2022.854269.].

Lipidomic Analysis of TRPC1 Ca2+-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet Open

Michael R. Bukowski, Brij B. Singh, James N. Roemmich, Kate Larson · 2022

The transient receptor potential canonical channel 1 (TRPC1) is a ubiquitous Ca 2+ -permeable integral membrane protein present in most tissues, including adipose and placenta, and functionally regulates energetic homeostasis. We demonstra…

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics Open

R. Karthik, Soumya Maity, Alagar R Muthukumar, Soundarya Kandala, Dhanendra Tomar , et al. · 2022

Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics Open

Viviane Nascimento Da Conceicao, Yuyang Sun, R. Karthik, Arun Chauhan, Amritha Raveendran , et al. · 2021

Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration Open

Naseem Ahamad, Yuyang Sun, Viviane Nascimento Da Conceicao, Caroline R. D. Xavier Paul Ezhilan, Mohan Natarajan , et al. · 2021

Increasing cytosolic Ca2+ levels restore cell proliferation and stem cell potency in aged MSCs Open

Naseem Ahamad, Yuyang Sun, Brij B. Singh · 2021

Transcriptome-wide Gene Expression Analysis in Peri-implantitis Reveals Candidate Cellular Pathways Open

Amy C Martin, Peng Zhou, Brij B. Singh, Georgios A. Kotsakis · 2021

Objective: Peri-implantitis is a condition resulting in destructive inflammation in the peri-implant soft tissue barrier. Clinically, it demonstrates vast clinical differences to periodontitis that suggest distinct inflammatory mechanisms.…

Calcium Signaling Regulates Autophagy and Apoptosis Open

Pramod Sukumaran, Viviane Nascimento Da Conceicao, Yuyang Sun, Naseem Ahamad, Luís R. Saraiva , et al. · 2021

Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental physiological functions such as cell growth/development, cell survival, neuronal development and/or the maintenance of cellular functions. The coordi…

Helminth derived factors inhibit neutrophil extracellular trap formation and inflammation in bacterial peritonitis Open

Arun Chauhan, Atul Sharma, Jitendra Kumar Tripathi, Yuyang Sun, Pramod Sukumran , et al. · 2021

Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury Open

Hak Joo Lee, Andrew Donati, Denis Féliers, Yuyang Sun, Yanli Ding , et al. · 2021

The mechanism of kidney injury in aging are not well understood. In order to identify hitherto unknown pathways of aging‐related kidney injury, we performed RNA‐Seq on kidney extracts of young and aged mice. Expression of chloride (Cl) cha…

Absence of TRPC1 Ca2+-permeable Channel Causes Placental and Fetal Growth Restriction in Mice Open

Kate Larson, Amy Bundy, James N. Roemmich, Brij B. Singh · 2021

Calcium channels and their role in regenerative medicine Open

Nassem Ahamad, Brij B. Singh · 2021

Stem cells hold indefinite self-renewable capability that can be differentiated into all desired cell types. Based on their plasticity potential, they are divided into totipotent (morula stage cells), pluripotent (embryonic stem cells), mu…

Sigma1 Receptor Inhibits TRPC1-Mediated Ca2+ Entry That Promotes Dopaminergic Cell Death Open

Yuyang Sun, Pramod Sukumaran, Brij B. Singh · 2020

Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren’s syndrome condition Open

Brij B. Singh, Joyce E. Ohm, Fredice O. Quenum Zanbede, Pooja Chauhan, Frans G. M. Kroese , et al. · 2020

Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells. Although the loss of salivary gland function is a major manifestation observed in pSS, the factors that could prom…

Isoproterenol-Dependent Activation of TRPM7 Protects Against Neurotoxin-Induced Loss of Neuroblastoma Cells Open

Yuyang Sun, Amrita Kamat, Brij B. Singh · 2020

Neuronal function and their survival depend on the activation of ion channels. Loss of ion channel function is known to induce neurodegenerative diseases such as Parkinson's that exhibit loss of dopaminergic neurons; however, mechanisms th…

Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity Open

Neeharika Nemani, Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, R. Karthik , et al. · 2020

Nutrient stress triggers transcriptional changes that limit Ca 2+ influx into mitochondria through the MCU.

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