Bakhtiyor Nosirov
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View article: P01.18.B MODELING GLIOBLASTOMA TREATMENT RESPONSES: INSIGHTS INTO TUMOR PLASTICITY AND THE ROLE OF THE TUMOR MICROENVIRONMENT
P01.18.B MODELING GLIOBLASTOMA TREATMENT RESPONSES: INSIGHTS INTO TUMOR PLASTICITY AND THE ROLE OF THE TUMOR MICROENVIRONMENT Open
BACKGROUND Glioblastoma relapse remains inevitable, placing these tumors among the most difficult to treat. Treatment challenges include inherent drug resistance, tumour’s plastic nature, and suppressive tumour microenvironment (TME). In o…
View article: OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES
OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES Open
BACKGROUND Precision medicine has transformed cancer treatment by tailoring therapies to the specific molecular aberrations of an individual patient’s tumor. The integration of high-resolution multi-omics with high-throughput functional pr…
View article: Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas Open
Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profiling in patient-derived organoids offers…
View article: Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer
Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer Open
Our integrated single-cell analysis provides a comprehensive understanding of the tumor heterogeneity in tamoxifen resistance. We envision this integrated single-cell epigenomic and transcriptomic measure will become a powerful approach to…
View article: Adenoviral delivery of the <i>CIITA</i> transgene induces T‐cell‐mediated killing in glioblastoma organoids
Adenoviral delivery of the <i>CIITA</i> transgene induces T‐cell‐mediated killing in glioblastoma organoids Open
The immunosuppressive nature of the tumor microenvironment poses a significant challenge to effective immunotherapies against glioblastoma (GB). Boosting the immune response is critical for successful therapy. Here, we adopted a cancer gen…
View article: Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma
Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma Open
View article: Most accurate mutations in SARS-CoV-2 genomes identified in Uzbek patients show novel amino acid changes
Most accurate mutations in SARS-CoV-2 genomes identified in Uzbek patients show novel amino acid changes Open
Purpose The rapid changes in the coronavirus genomes created new strains after the first variation was found in Wuhan in 2019. SARS-CoV-2 genotypes should periodically undergo whole genome sequencing to control it because it has been extre…
View article: Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts Open
View article: Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells
Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells Open
Nuclear factor of activated T cells 5 (NFAT5) and cyclooxygenase 2 (COX2; PTGS2) both participate in diverse pathologies including cancer progression. However, the biological role of the NFAT5-COX2 signaling pathway in human endometrial ca…
View article: T-Cell-Mediated Killing in Glioblastoma Organoids induced by Adenoviral Delivery of the CIITA Transgene
T-Cell-Mediated Killing in Glioblastoma Organoids induced by Adenoviral Delivery of the CIITA Transgene Open
The immunosuppressive nature of the tumor microenvironment poses a significant challenge to effective immunotherapies against glioblastoma (GB). Boosting the immune response is critical for a successful therapy. Here, we adopted a cancer g…
View article: Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing
Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing Open
The rapid changes in the coronavirus genomes are creating new strains over time after the first variation found in Wuhan in 2019. SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) genotypes need periodically undergo whole genome…
View article: Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts Open
Background A major contributing factor to glioblastoma (GBM) development and progression is its ability to evade the immune system by creating an immune-suppressive environment, where GBM-associated myeloid cells, including resident microg…
View article: The 3D genomic landscape of differential response to EGFR/HER2 inhibition in endocrine-resistant breast cancer cells
The 3D genomic landscape of differential response to EGFR/HER2 inhibition in endocrine-resistant breast cancer cells Open
Our study has provided significant insights into our understanding of 3D genomic landscape changes in response to EGFR/HER2 Inhibition in endocrine-resistant breast cancer cells. Our data provides a rich resource for further evaluating chr…
View article: Reciprocal fine-tuning of progesterone and prolactin-regulated gene expression in breast cancer cells
Reciprocal fine-tuning of progesterone and prolactin-regulated gene expression in breast cancer cells Open
View article: Mapping circulating serum miRNAs to their immune-related target mRNAs
Mapping circulating serum miRNAs to their immune-related target mRNAs Open
Immune-related mRNAs have more miRNA binding sites in general, not just for serum miRNAs; likewise, serum miRNAs target many more mRNAs than non-serum miRNAs overall, regardless of whether they are immune related or not. Nevertheless, thes…