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View article: Real-world evidence of remdesivir in formerly hospitalized COVID-19 patients: patient-reported and functional outcomes
Real-world evidence of remdesivir in formerly hospitalized COVID-19 patients: patient-reported and functional outcomes Open
View article: The Effect of Opioids and Benzodiazepines on Exacerbation Rate and Overall Survival in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Non-Invasive Ventilation
The Effect of Opioids and Benzodiazepines on Exacerbation Rate and Overall Survival in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Non-Invasive Ventilation Open
Background: There is a growing concern that opioids and benzodiazepines can depress the respiratory drive and could contribute to worsening respiratory failure and higher exacerbation frequency in COPD. However, the relationship between th…
View article: Long-Term Adherence to Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnoea Set Up in a Complete Remote Pathway: A Single-Centre Service Evaluation Project
Long-Term Adherence to Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnoea Set Up in a Complete Remote Pathway: A Single-Centre Service Evaluation Project Open
Background: Continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnoea (OSA). Maintaining adherence to CPAP in the long term is a clinical problem, and numerous factors have been identified that imp…
View article: Assessment of bronchodilator responsiveness to salbutamol or ipratropium using different criteria in treatment-naïve patients with asthma and COPD
Assessment of bronchodilator responsiveness to salbutamol or ipratropium using different criteria in treatment-naïve patients with asthma and COPD Open
Fewer patients show BDR+ according to the 2021 criteria in comparison with the 2005 recommendations, and protocols for BDR testing may consider the assessment of response to both SABA and SAMA after 30 minutes.
View article: Exhaled and Systemic Biomarkers to Aid the Diagnosis of Bronchial Asthma in Elite Water Sports Athletes
Exhaled and Systemic Biomarkers to Aid the Diagnosis of Bronchial Asthma in Elite Water Sports Athletes Open
Purpose Our aim was to evaluate the accuracy of a combined airway inflammatory biomarker assessment in diagnosing asthma in elite water sports athletes. Methods Members of the Hungarian Olympic and Junior Swim Team and elite athletes from …
View article: Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension
Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension Open
Cytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cy…
View article: P42 Fixed versus variable pressure modes of long-term non-invasive ventilation in patients with chronic hypercapnic COPD
P42 Fixed versus variable pressure modes of long-term non-invasive ventilation in patients with chronic hypercapnic COPD Open
Long-term non-invasive ventilation (LT-NIV) is an emerging treatment for patients with chronic hypercapnic COPD. The ventilatory support can be delivered either through fixed pressure support or by continuously adjusting pressures to achi…
View article: P34 The impact of COPD on the disease course in OSA
P34 The impact of COPD on the disease course in OSA Open
Introduction The co-existence of chronic obstructive pulmonary disease (COPD) in obstructive sleep apnoea (OSA) is defined as the 'Overlap Syndrome' (OS). Overlap syndrome is associated with worse outcomes in COPD; however, its impact in p…
View article: The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis
The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis Open
Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many lines of evidence suggest that the disturbances in circadian rhythm are responsible for the development of CVDs; however, circadian misalignment is not yet…
View article: The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea
The Role of Gut Bacteriome in Asthma, Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnoea Open
The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases a…
View article: Clinical Predictors of Lung-Function Decline in Systemic-Sclerosis-Associated Interstitial Lung Disease Patients with Normal Spirometry
Clinical Predictors of Lung-Function Decline in Systemic-Sclerosis-Associated Interstitial Lung Disease Patients with Normal Spirometry Open
Interstitial lung disease (ILD) is the leading cause of mortality in systemic sclerosis (SSc). Progressive pulmonary fibrosis (PPF) is defined as progression in 2 domains including clinical, radiological or lung-function parameters. Our ai…
View article: Hypercapnia in COPD: Causes, Consequences, and Therapy
Hypercapnia in COPD: Causes, Consequences, and Therapy Open
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder that may lead to gas exchange abnormalities, including hypercapnia. Chronic hypercapnia is an independent risk factor of mortality in COPD, leading to epith…
View article: Postoperative respiratory complications in children with obstructive sleep apnoea syndrome
Postoperative respiratory complications in children with obstructive sleep apnoea syndrome Open
Comorbidities are more closely linked with PoRCs than OSA severity. In patients without comorbidity, PoRCs are associated with OSA severity and usually occur within the first 2 hours after the intervention.
View article: Pulmonary vascular remodeling and right ventricular adaptation in precapillary pulmonary hypertension
Pulmonary vascular remodeling and right ventricular adaptation in precapillary pulmonary hypertension Open
Background: In precapillary pulmonary hypertension (PH) as pulmonary arterial hypertension (PAH), chronic thromboembolic PH (CTPEH) and PH due to hypoxia and lung disease (HPH) the different pathomechanisms of vascular remodeling result in…
View article: Assessing Treatment Success or Failure as an Outcome in Randomised Clinical Trials of COPD Exacerbations. A Meta-Epidemiological Study
Assessing Treatment Success or Failure as an Outcome in Randomised Clinical Trials of COPD Exacerbations. A Meta-Epidemiological Study Open
A recently published ERS core outcome set recommends that all trials of COPD exacerbation management should assess the treatment success (or “cure” of the exacerbation), defined as a dichotomous measure of the overall outcome of an exacerb…
View article: S101 Methods for assessing the success or failure of COPD exacerbation treatments in therapeutic clinical trials: A meta-epidemiological systematic review
S101 Methods for assessing the success or failure of COPD exacerbation treatments in therapeutic clinical trials: A meta-epidemiological systematic review Open
Introduction The overall outcome of a COPD exacerbation (treatment success or failure) is a critical outcome for clinical trials evaluating the management of COPD exacerbations. However, trials use heterogeneous definitions and instruments…
View article: ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations
ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations Open
Clinical trials evaluating the management of acute exacerbations of COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, a consensus-base…
View article: Blood eosinophils on hospital admission for COPD exacerbation do not predict the recurrence of moderate and severe relapses
Blood eosinophils on hospital admission for COPD exacerbation do not predict the recurrence of moderate and severe relapses Open
Background and objective The relationship between hospitalisation with an eosinophilic acute exacerbation of COPD (AE-COPD) and future relapses is unclear. We aimed to explore this association by following 152 patients for 12 months after …
View article: Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease: the COS-AECOPD ERS Task Force study protocol
Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease: the COS-AECOPD ERS Task Force study protocol Open
Randomised controlled trials (RCTs) on the management of COPD exacerbations evaluate heterogeneous outcomes, often omitting those that are clinically important and patient relevant. This limits their usability and comparability. A core out…
View article: Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD
Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD Open